Serotonin Improves High Fat Diet Induced Obesity in Mice

Hitoshi Watanabe; Tatsuya Nakano; Ryo Saito; D Aksaka; K Saito; Hideki Ogasawara; Takeshi Minashima; Kohtaro Miyazawa; Takashi Kanaya; Ikuro Takakura; N Inoue; Ikuo Ikeda; X Chen; M. Miyake; haruki kitazawa; H Shirakawa; Katsuyoshi Sato; Koji Tahara; Yuya Nagasawa; Kouichi Watanabe; Michael Rose; Hisashi Aso

doi:10.1371/journal.pone.0147143

Serotonin Improves High Fat Diet Induced Obesity in Mice

Hitoshi Watanabe, Tatsuya Nakano, Ryo Saito, D Aksaka, K Saito, Hideki Ogasawara, Takeshi Minashima, Kohtaro Miyazawa, Takashi Kanaya, Ikuro Takakura, N Inoue, Ikuo Ikeda, X Chen, M. Miyake, haruki kitazawa, H Shirakawa, Katsuyoshi Sato, Koji Tahara, Yuya Nagasawa, Kouichi WatanabeMichael Rose, Hisashi Aso

Adran y Gwyddorau Bywyd

Tohoku University

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

48 Dyfyniadau (Scopus)

175 Wedi eu Llwytho i Lawr (Pure)

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There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	e0147143
Cyfnodolyn	PLoS ONE
Cyfrol	11
Rhif cyhoeddi	1
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1371/journal.pone.0147143
Statws	Cyhoeddwyd - 14 Ion 2016

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10.1371/journal.pone.0147143Trwydded: CC BY

Seroteonin Improves High Fat Diet Induced Obesity in MiceFersiwn derfynol wedi’i chyhoeddi, 1.11 MBTrwydded: CC BY

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http://hdl.handle.net/2160/30645

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Watanabe, H., Nakano, T., Saito, R., Aksaka, D., Saito, K., Ogasawara, H., Minashima, T., Miyazawa, K., Kanaya, T., Takakura, I., Inoue, N., Ikeda, I., Chen, X., Miyake, M., kitazawa, H., Shirakawa, H., Sato, K., Tahara, K., Nagasawa, Y., ... Aso, H. (2016). Serotonin Improves High Fat Diet Induced Obesity in Mice. PLoS ONE, 11(1), erthygl e0147143. https://doi.org/10.1371/journal.pone.0147143

@article{0030088508d04a62983a9a8ad24a77da,

title = "Serotonin Improves High Fat Diet Induced Obesity in Mice",

abstract = "There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle.",

author = "Hitoshi Watanabe and Tatsuya Nakano and Ryo Saito and D Aksaka and K Saito and Hideki Ogasawara and Takeshi Minashima and Kohtaro Miyazawa and Takashi Kanaya and Ikuro Takakura and N Inoue and Ikuo Ikeda and X Chen and M. Miyake and haruki kitazawa and H Shirakawa and Katsuyoshi Sato and Koji Tahara and Yuya Nagasawa and Kouichi Watanabe and Michael Rose and Hisashi Aso",

year = "2016",

month = jan,

day = "14",

doi = "10.1371/journal.pone.0147143",

language = "English",

volume = "11",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

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}

Watanabe, H, Nakano, T, Saito, R, Aksaka, D, Saito, K, Ogasawara, H, Minashima, T, Miyazawa, K, Kanaya, T, Takakura, I, Inoue, N, Ikeda, I, Chen, X, Miyake, M, kitazawa, H, Shirakawa, H, Sato, K, Tahara, K, Nagasawa, Y, Watanabe, K, Rose, M & Aso, H 2016, 'Serotonin Improves High Fat Diet Induced Obesity in Mice', PLoS ONE, cyfrol. 11, rhif 1, e0147143. https://doi.org/10.1371/journal.pone.0147143

TY - JOUR

T1 - Serotonin Improves High Fat Diet Induced Obesity in Mice

AU - Watanabe, Hitoshi

AU - Nakano, Tatsuya

AU - Saito, Ryo

AU - Aksaka, D

AU - Saito, K

AU - Ogasawara, Hideki

AU - Minashima, Takeshi

AU - Miyazawa, Kohtaro

AU - Kanaya, Takashi

AU - Takakura, Ikuro

AU - Inoue, N

AU - Ikeda, Ikuo

AU - Chen, X

AU - Miyake, M.

AU - kitazawa, haruki

AU - Shirakawa, H

AU - Sato, Katsuyoshi

AU - Tahara, Koji

AU - Nagasawa, Yuya

AU - Watanabe, Kouichi

AU - Rose, Michael

AU - Aso, Hisashi

PY - 2016/1/14

Y1 - 2016/1/14

N2 - There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle.

AB - There are two independent serotonin (5-HT) systems of organization: one in the central nervous system and the other in the periphery. 5-HT affects feeding behavior and obesity in the central nervous system. On the other hand, peripheral 5-HT also may play an important role in obesity, as it has been reported that 5-HT regulates glucose and lipid metabolism. Here we show that the intraperitoneal injection of 5-HT to mice inhibits weight gain, hyperglycemia and insulin resistance and completely prevented the enlargement of intra-abdominal adipocytes without having any effect on food intake when on a high fat diet, but not on a chow diet. 5-HT increased energy expenditure, O2 consumption and CO2 production. This novel metabolic effect of peripheral 5-HT is critically related to a shift in the profile of muscle fiber type from fast/glycolytic to slow/oxidative in soleus muscle. Additionally, 5-HT dramatically induced an increase in the mRNA expression of peroxisome proliferator-activated receptor coactivator 1α (PGC-1α)-b and PGC-1α-c in soleus muscle. The elevation of these gene mRNA expressions by 5-HT injection was inhibited by treatment with 5-HT receptor (5HTR) 2A or 7 antagonists. Our results demonstrate that peripheral 5-HT may play an important role in the relief of obesity and other metabolic disorders by accelerating energy consumption in skeletal muscle.

UR - http://hdl.handle.net/2160/30645

U2 - 10.1371/journal.pone.0147143

DO - 10.1371/journal.pone.0147143

M3 - Article

C2 - 26766570

SN - 1932-6203

VL - 11

JO - PLoS ONE

JF - PLoS ONE

IS - 1

M1 - e0147143

ER -

Serotonin Improves High Fat Diet Induced Obesity in Mice

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