Crynodeb
The secreted Mycobacterium tuberculosis complex proteins CFP-10 and ESAT-6 have recently been shown to play an essential role in tuberculosis pathogenesis. We have determined the solution structure of the tight, 1:1 complex formed by CFP-10 and ESAT-6, and employed fluorescence microscopy to demonstrate specific binding of the complex to the surface of macrophage and monocyte cells. A striking feature of the complex is the long flexible arm formed by the C-terminus of CFP-10, which was found to be essential for binding to the surface of cells. The surface features of the CFP-10 · ESAT-6 complex, together with observed binding to specific host cells, strongly suggest a key signalling role for the complex, in which binding to cell surface receptors leads to modulation of host cell behaviour to the advantage of the pathogen.
Iaith wreiddiol | Saesneg |
---|---|
Tudalennau (o-i) | 2491-2498 |
Nifer y tudalennau | 8 |
Cyfnodolyn | EMBO Journal |
Cyfrol | 24 |
Rhif cyhoeddi | 14 |
Dyddiad ar-lein cynnar | 23 Mai 2005 |
Dynodwyr Gwrthrych Digidol (DOIs) | |
Statws | Cyhoeddwyd - 20 Gorff 2005 |