The antigen-specific memory CD8+ T-cell response induced by BCG in cattle resides in the CD8+γ/δTCR-CD45RO+ T-cell population

Alison E. Hogg, Andrew Worth, Peter Beverley, Christopher J. Howard, Bernardo Villarreal-Ramos*

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

23 Dyfyniadau(SciVal)

Crynodeb

Tuberculosis (TB) remains a worldwide leading cause of death among infectious diseases. Development of safer and more efficacious vaccines requires a basic understanding of the protective mechanisms induced by BCG. Here we show that vaccination of cattle with BCG induces CD8+γ/δTCR-CD45RO+ T-cells that can produce IFN-γ, up-regulate transcription and expression of perforin, lyse BCG-infected monocyte-derived macrophages (MoMφ{symbol}) and contribute to a reduction in the number of intracellular mycobacteria. We also observed BCG-induced CD8+ responses in vivo. After infection of cattle with Mycobacterium bovis, CD8+γ/δTCR-CD45RO+ cells responded more strongly to M. bovis-infected MoMφ{symbol} than to BCG-infected MoMφ{symbol}. These results indicate that the antigen-specific CD8+ memory response resides in the CD8+γ/δTCR-CD45RO+ cell population.

Iaith wreiddiolSaesneg
Tudalennau (o-i)270-279
Nifer y tudalennau10
CyfnodolynVaccine
Cyfrol27
Rhif cyhoeddi2
Dyddiad ar-lein cynnar07 Tach 2008
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 07 Ion 2009

Ôl bys

Gweld gwybodaeth am bynciau ymchwil 'The antigen-specific memory CD8+ T-cell response induced by BCG in cattle resides in the CD8+γ/δTCR-CD45RO+ T-cell population'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

Dyfynnu hyn