TY - JOUR
T1 - The Automation of Science
AU - King, Ross Donald
AU - Rowland, Jeremy John
AU - Oliver, Stephen G.
AU - Young, Michael
AU - Aubrey, Wayne
AU - Byrne, Emma Louise
AU - Liakata, Maria
AU - Markham, Magdalena
AU - Pir, Pinar
AU - Soldatova, Larisa Nikolaevna
AU - Sparkes, Andrew Charles
AU - Whelan, Kenneth Edward
AU - Clare, Amanda Janet
N1 - King, R. D., Rowland, J., Oliver, S. G., Young, M., Aubrey, W., Byrne, E.,Liakata, M., Markham, M., Pir, P., Soldatova, L. N., Sparkes, A., Whelan, K. E., Clare, A. (2009). The automation of science. Science, 3 April 2009, 85-89.
Sponsorship: BBSRC/ Royal Commission for the Great Exhibition of 1851/ EPSRC/Royal Academy of Engineering/RC-UK
IMPF: 29.75 RONO: 00
PY - 2009/4/3
Y1 - 2009/4/3
N2 - The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist 'Adam,' which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.
AB - The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist 'Adam,' which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.
U2 - 10.1126/science.1165620
DO - 10.1126/science.1165620
M3 - Article
C2 - 19342587
SN - 0036-8075
VL - 324
SP - 85
EP - 89
JO - Science
JF - Science
IS - 5923
ER -