The complete genome sequence of Mycobacterium bovis

Thierry Garnier, Karin Eiglmeier, Jean Christophe Camus, Nadine Medina, Huma Mansoor, Melinda Pryor, Stephanie Duthoy, Sophie Grondin, Celine Lacroix, Christel Monsempe, Sylvie Simon, Barbara Harris, Rebecca Atkin, Jon Doggett, Rebecca Mayes, Lisa Keating, Paul R. Wheeler, Julian Parkhill, Bart G. Barrell, Stewart T. ColeStephen V. Gordon*, R. Glyn Hewinson

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

785 Dyfyniadau (Scopus)

Crynodeb

Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and man, with worldwide annual losses to agriculture of $3 billion. The human burden of tuberculosis caused by the bovine tubercle bacillus is still largely unknown. M. bovis was also the progenitor for the M. bovis bacillus Calmette-Guérin vaccine strain, the most widely used human vaccine. Here we describe the 4,345,492-bp genome sequence of M. bovis AF2122/97 and its comparison with the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Strikingly, the genome sequence of M. bovis is >99.95% identical to that of M. tuberculosis, but deletion of genetic information has led to a reduced genome size. Comparison with M. leprae reveals a number of common gene losses, suggesting the removal of functional redundancy. Cell wall components and secreted proteins show the greatest variation, indicating their potential role in host-bacillus interactions or immune evasion. Furthermore, there are no genes unique to M. bovis, implying that differential gene expression may be the key to the host tropisms of human and bovine bacilli. The genome sequence therefore offers major insight on the evolution, host preference, and pathobiology of M. bovis.

Iaith wreiddiolSaesneg
Tudalennau (o-i)7877-7882
Nifer y tudalennau6
CyfnodolynProceedings of the National Academy of Sciences of the United States of America
Cyfrol100
Rhif cyhoeddi13
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 24 Meh 2003

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