@article{0b4cf65737a84952815f5fd7dc3d2e9f,
title = "The effect of bovine colostrum supplementation on intestinal injury and circulating intestinal bacterial DNA following exercise in the heat",
abstract = "Purpose: Exercise-induced changes in intestinal permeability are exacerbated in the heat. The aim of this study was to determine the effect of 14 days of bovine colostrum (Col) supplementation on intestinal cell damage (plasma intestinal fatty acid-binding protein, I-FABP) and bacterial translocation (plasma bacterial DNA) following exercise in the heat. Methods: In a double-blind, placebo-controlled, crossover design, 12 males completed two experimental arms (14 days of 20 g/day supplementation with Col or placebo, Plac) consisting of 60 min treadmill running at 70% maximal aerobic capacity (30 °C, 60% relative humidity). Blood samples were collected pre-exercise (Pre-Ex), post-exercise (Post-Ex) and 1 h post-exercise (1 h Post-Ex) to determine plasma I-FABP concentration, and bacterial DNA (for an abundant gut species, Bacteroides). Results: Two-way repeated measures ANOVA revealed an arm × time interaction for I-FABP (P = 0.005, with greater Post-Ex increase in Plac than Col, P = 0.01: Plac 407 ± 194% of Pre-Ex vs Col, 311 ± 134%) and 1 h Post-Ex (P = 0.036: Plac 265 ± 80% of Pre-Ex vs Col, 229 ± 56%). There was no interaction (P = 0.904) but there was a main effect of arm (P = 0.046) for plasma Bacteroides/total bacterial DNA, with lower overall levels evident in Col. Conclusion: This is the first investigation to demonstrate that Col can be effective at reducing intestinal injury following exercise in the heat, but exercise responses (temporal pattern) of bacterial DNA were not influenced by Col (although overall levels may be lower).",
keywords = "intestinal fatty acid-binding protein, cellular injury, strenuous exercise, bacterial translocation, intestinal permeability, core temperature, environment, Cellular injury, Strenuous exercise, Intestinal permeability, Bacterial translocation, Core temperature, Intestinal fatty acid-binding protein, Environment, Humans, Male, Cell-Free Nucleic Acids/blood, Cattle, Humidity, Adult, Double-Blind Method, Intestines/drug effects, Hot Temperature, Bacterial Translocation/drug effects, Cross-Over Studies, Animals, Running, Colostrum, Dietary Supplements, Fatty Acid-Binding Proteins/blood",
author = "March, {Daniel Scott} and Jones, {Arwel Wyn} and Rhys Thatcher and Glen Davison",
note = "Funding Information: Funding No funding was received for this work but DSM, AWJ and GD have received funding in the past for other work: Daniel S. March{\textquoteright}s MPhil was supported by a Knowledge Economy Skills Scholarship, awarded in 2010 and completed in 2011, which was a collaborative project with an external partner, The Repair and Protection Foods Ltd (supplier for Neovite Colostrum UK). This project was part-funded by the European Social Fund through the European Union{\textquoteright}s Convergence Programme (West Wales and the Valleys) and administered by the Welsh Government. Arwel W. Jones{\textquoteright} PhD was supported by a Knowledge Economy Skills Scholarship, awarded in 2010 and completed in 2013, which was a collaborative project with an external partner, The Golden Dairy Ltd (supplier for Neovite Colostrum UK). This project was part-funded by the European Social Fund through the European Union{\textquoteright}s Convergence Programme (West Wales and the Valleys) and administered by the Welsh Government. GD has previously received funding from Neovite Colostrum UK (2008, 2010, 2013) but no funding was received for the present study. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2019",
month = jun,
day = "1",
doi = "10.1007/s00394-018-1670-9",
language = "English",
volume = "58",
pages = "1441--1451",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "Springer Nature",
number = "4",
}
