@article{3918c8da2e3d4173b9a5296f782f9719,
title = "The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution ",
abstract = "To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.",
author = "{Bovine Genome Sequencing and Analysis Consortium} and Elsik, {Christine G.} and Tellam, {Ross L.} and Worley, {Kim C.} and Gibbs, {R. A.} and Muzny, {D. M.} and Weinstock, {G. M.} and Adelson, {D. L.} and Eichler, {E. E.} and L. Elnitski and R. Guigo and Hamernik, {D. L.} and Kappes, {S. M.} and Lewin, {H. A.} and Lynn, {D. J.} and Nicholas, {F. W.} and A. Reymond and M. Rijnkels and Skow, {L. C.} and Zdobnov, {E. M.} and L. Schook and J. Womack and T. Alioto and Antonarakis, {S. E.} and A. Astashyn and Chapple, {C. E.} and H.-C. Chen and J. Chrast and F. Camara and O. Ermolaeva and Henrichsen, {C. N.} and W. Hlavina and Y. Kapustin and B. Kiryutin and P. Kitts and F. Kokocinski and M. Landrum and D. Maglott and K. Pruitt and V. Sapojnikov and Searle, {S. M.} and V. Solovyev and A. Souvorov and C. Ucla and C. Wyss and Anzola, {J. M.} and D. Gerlach and E. Elhaik and D. Graur and Larkin, {D. M.} and M. Hernandez",
year = "2009",
month = apr,
day = "24",
doi = "10.1126/science.1169588",
language = "English",
volume = "324",
pages = "522--528",
journal = "Science",
issn = "1095-9203",
publisher = "American Association for the Advancement of Science",
number = "5926",
}