The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle

Fabio Formenti; Alba Cortés; Michela Deiana; Susannah Salter; Julian Parkhill; Matt Berriman; Gabriel Rinaldi; Cinzia Cantacessi

doi:10.1093/infdis/jiad288

The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle

Fabio Formenti, Alba Cortés, Michela Deiana, Susannah Salter, Julian Parkhill, Matt Berriman, Gabriel Rinaldi, Cinzia Cantacessi

Adran y Gwyddorau Bywyd

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

5 Dyfyniadau (Scopus)

Crynodeb

While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, host-pathogen interactions, and disease pathophysiology. We investigated the presence of microorganisms inhabiting tissues of the human parasite Schistosoma mansoni. In situ hybridization using a pan-bacterial 16S rRNA gene probe revealed bacteria colonizing key developmental stages that were successfully removed after antibiotic treatment of live parasites. Understanding the composition and function of the S. mansoni-associated microbiota may lead to the development of novel microbiome-targeting control strategies.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	1299-1303
Nifer y tudalennau	5
Cyfnodolyn	The Journal of infectious diseases
Cyfrol	228
Rhif cyhoeddi	9
Dyddiad ar-lein cynnar	24 Gorff 2023
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1093/infdis/jiad288
Statws	Cyhoeddwyd - 01 Tach 2023

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

Mynediad at Ddogfen

10.1093/infdis/jiad288

Cysylltiad parhaol

Dolen barhaus

Ffeiliau eraill a chysylltiadau

Dolen i’r cyhoeddiad yn Scopus

1 Wrthi'n gweithredu

Functional genomics to unveil the intramammalian development of schistosomes
Rinaldi, G. (Prif Ymchwilydd)
Medical Research Council
01 Awst 2022 → 31 Ion 2026
Prosiect: Ymchwil a ariannwyd yn allanol

Dyfynnu hyn

@article{0f8e4a6a4839485593fbaa5d3c34425e,

title = "The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle",

abstract = "While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, host-pathogen interactions, and disease pathophysiology. We investigated the presence of microorganisms inhabiting tissues of the human parasite Schistosoma mansoni. In situ hybridization using a pan-bacterial 16S rRNA gene probe revealed bacteria colonizing key developmental stages that were successfully removed after antibiotic treatment of live parasites. Understanding the composition and function of the S. mansoni-associated microbiota may lead to the development of novel microbiome-targeting control strategies.",

keywords = "fluorescence in situ hybridization, parasite-associated microbiota, schistosomes, Animals, Bacteria/genetics, Humans, Parasites/genetics, Schistosoma mansoni/genetics, RNA, Ribosomal, 16S/genetics, Helminths, Life Cycle Stages, Schistosomiasis mansoni/parasitology",

author = "Fabio Formenti and Alba Cort{\'e}s and Michela Deiana and Susannah Salter and Julian Parkhill and Matt Berriman and Gabriel Rinaldi and Cinzia Cantacessi",

note = "Funding Information: Financial support. This work was supported by the IRCCS Sacro Cuore Don Calabria, Verona Italy (MPhil scholarship to F. F.); UK Research and Innovation (UKRI; Future Leaders Fellowship to G. R.); and the Ministry of Health Italy Fondi Ricerca Corrente-L3, P2 to IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy. C. C.{\textquoteright}s laboratory is supported by the UKRI and the Isaac Newton Trust. Funding to pay the Open Access publication charges for this article was provided by the University of Cambridge. Funding Information: This work was supported by the IRCCS Sacro Cuore Don Calabria, Verona Italy (MPhil scholarship to F. F.); UK Research and Innovation (UKRI; Future Leaders Fellowship to G. R.); and the Ministry of Health Italy Fondi Ricerca Corrente-L3, P2 to IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy. C. C.{\textquoteright}s laboratory is supported by the UKRI and the Isaac Newton Trust. Funding to pay the Open Access publication charges for this article was provided by the University of Cambridge. Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2023",

month = nov,

day = "1",

doi = "10.1093/infdis/jiad288",

language = "English",

volume = "228",

pages = "1299--1303",

journal = "The Journal of infectious diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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AU - Formenti, Fabio

AU - Cortés, Alba

AU - Deiana, Michela

AU - Salter, Susannah

AU - Parkhill, Julian

AU - Berriman, Matt

AU - Rinaldi, Gabriel

AU - Cantacessi, Cinzia

N1 - Funding Information: Financial support. This work was supported by the IRCCS Sacro Cuore Don Calabria, Verona Italy (MPhil scholarship to F. F.); UK Research and Innovation (UKRI; Future Leaders Fellowship to G. R.); and the Ministry of Health Italy Fondi Ricerca Corrente-L3, P2 to IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy. C. C.’s laboratory is supported by the UKRI and the Isaac Newton Trust. Funding to pay the Open Access publication charges for this article was provided by the University of Cambridge. Funding Information: This work was supported by the IRCCS Sacro Cuore Don Calabria, Verona Italy (MPhil scholarship to F. F.); UK Research and Innovation (UKRI; Future Leaders Fellowship to G. R.); and the Ministry of Health Italy Fondi Ricerca Corrente-L3, P2 to IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy. C. C.’s laboratory is supported by the UKRI and the Isaac Newton Trust. Funding to pay the Open Access publication charges for this article was provided by the University of Cambridge. Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2023/11/1

Y1 - 2023/11/1

N2 - While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, host-pathogen interactions, and disease pathophysiology. We investigated the presence of microorganisms inhabiting tissues of the human parasite Schistosoma mansoni. In situ hybridization using a pan-bacterial 16S rRNA gene probe revealed bacteria colonizing key developmental stages that were successfully removed after antibiotic treatment of live parasites. Understanding the composition and function of the S. mansoni-associated microbiota may lead to the development of novel microbiome-targeting control strategies.

AB - While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, host-pathogen interactions, and disease pathophysiology. We investigated the presence of microorganisms inhabiting tissues of the human parasite Schistosoma mansoni. In situ hybridization using a pan-bacterial 16S rRNA gene probe revealed bacteria colonizing key developmental stages that were successfully removed after antibiotic treatment of live parasites. Understanding the composition and function of the S. mansoni-associated microbiota may lead to the development of novel microbiome-targeting control strategies.

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KW - Bacteria/genetics

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KW - Schistosoma mansoni/genetics

KW - RNA, Ribosomal, 16S/genetics

KW - Helminths

KW - Life Cycle Stages

KW - Schistosomiasis mansoni/parasitology

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DO - 10.1093/infdis/jiad288

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SN - 0022-1899

VL - 228

SP - 1299

EP - 1303

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - 9

ER -

The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle

Crynodeb

NDC y CU

Mynediad at Ddogfen

Cysylltiad parhaol

Ffeiliau eraill a chysylltiadau

Ôl bys

Prosiectau

Functional genomics to unveil the intramammalian development of schistosomes

Dyfynnu hyn