This study seeks to investigate firm-level innovation, exploring whether social relationships located in knowledge networks influence the transfer of university knowledge to Ghanaian firms. Firms’ informal relationships with universities have been under-researched in developing economies. The extant literature suggests that informal relationships in the context of economies with advanced regional and national innovation systems have a positive association with firm level innovation performance. The research project employs a cross-sectional survey of 245 firms in Ghana. The aim of the project is to explore the influence of informal mechanisms of university knowledge transfer on firm level innovation performance in Ghana. The study adopts a structural model with partial least squares as an analytical technique. The findings reveal that to deliver positive results in a firm’s innovation performance by informal means, a well-coordinated social system to attract research knowledge from all aspects of the university system is required. The research project’s implications for Ghana’s innovation system include a need to be aware of the impact of corruption and lack of intellectual property rights on the efficacy informal knowledge transfer.