The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

Margot A. Skinner; D. Neil Wedlock; Geoffrey W. De Lisle; Michèle M. Cooke; Ricardo E. Tascon; Jose C. Ferraz; Douglas B. Lowrie; H. Martin Vordermeier; R. Glyn Hewinson; Bryce M. Buddle

doi:10.1128/IAI.73.7.4441-4444.2005

The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

Margot A. Skinner, D. Neil Wedlock, Geoffrey W. De Lisle, Michèle M. Cooke, Ricardo E. Tascon, Jose C. Ferraz, Douglas B. Lowrie, H. Martin Vordermeier, R. Glyn Hewinson, Bryce M. Buddle^*

^*Awdur cyfatebol y gwaith hwn

TB buchol, clefydau a rheolaeth

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

60 Dyfyniadau (Scopus)

Crynodeb

Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	4441-4444
Nifer y tudalennau	4
Cyfnodolyn	Infection and Immunity
Cyfrol	73
Rhif cyhoeddi	7
Dyddiad ar-lein cynnar	21 Meh 2005
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1128/IAI.73.7.4441-4444.2005
Statws	Cyhoeddwyd - 01 Gorff 2005

NDC y CU

Mae’r allbwn hwn yn cyfrannu at y Nod(au) Datblygu Cynaliadwy canlynol

Mynediad at Ddogfen

10.1128/IAI.73.7.4441-4444.2005

Cysylltiad parhaol

Dolen barhaus

Ffeiliau eraill a chysylltiadau

Link to publication in Scopus

Ôl bys

Gweld gwybodaeth am bynciau ymchwil 'The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

Dyfynnu hyn

Skinner, M. A., Wedlock, D. N., De Lisle, G. W., Cooke, M. M., Tascon, R. E., Ferraz, J. C., Lowrie, D. B., Vordermeier, H. M., Hewinson, R. G., & Buddle, B. M. (2005). The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. Infection and Immunity, 73(7), 4441-4444. https://doi.org/10.1128/IAI.73.7.4441-4444.2005

@article{2ee16375136147038b4db0ec5850b269,

title = "The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis",

abstract = "Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Gu{\'e}rin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.",

author = "Skinner, {Margot A.} and Wedlock, {D. Neil} and {De Lisle}, {Geoffrey W.} and Cooke, {Mich{\`e}le M.} and Tascon, {Ricardo E.} and Ferraz, {Jose C.} and Lowrie, {Douglas B.} and Vordermeier, {H. Martin} and Hewinson, {R. Glyn} and Buddle, {Bryce M.}",

year = "2005",

month = jul,

day = "1",

doi = "10.1128/IAI.73.7.4441-4444.2005",

language = "English",

volume = "73",

pages = "4441--4444",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "7",

}

Skinner, MA, Wedlock, DN, De Lisle, GW, Cooke, MM, Tascon, RE, Ferraz, JC, Lowrie, DB, Vordermeier, HM, Hewinson, RG & Buddle, BM 2005, 'The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis', Infection and Immunity, cyfrol. 73, rhif 7, tt. 4441-4444. https://doi.org/10.1128/IAI.73.7.4441-4444.2005

The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. / Skinner, Margot A.; Wedlock, D. Neil; De Lisle, Geoffrey W. et al.
Yn: Infection and Immunity, Cyfrol 73, Rhif 7, 01.07.2005, t. 4441-4444.

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

TY - JOUR

T1 - The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

AU - Skinner, Margot A.

AU - Wedlock, D. Neil

AU - De Lisle, Geoffrey W.

AU - Cooke, Michèle M.

AU - Tascon, Ricardo E.

AU - Ferraz, Jose C.

AU - Lowrie, Douglas B.

AU - Vordermeier, H. Martin

AU - Hewinson, R. Glyn

AU - Buddle, Bryce M.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.

AB - Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.

UR - http://www.scopus.com/inward/record.url?scp=21544454118&partnerID=8YFLogxK

U2 - 10.1128/IAI.73.7.4441-4444.2005

DO - 10.1128/IAI.73.7.4441-4444.2005

M3 - Article

C2 - 15972546

AN - SCOPUS:21544454118

SN - 0019-9567

VL - 73

SP - 4441

EP - 4444

JO - Infection and Immunity

JF - Infection and Immunity

IS - 7

ER -

Skinner MA, Wedlock DN, De Lisle GW, Cooke MM, Tascon RE, Ferraz JC et al. The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. Infection and Immunity. 2005 Gor 1;73(7):4441-4444. Epub 2005 Meh 21. doi: 10.1128/IAI.73.7.4441-4444.2005