The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer

Nuno Vale*, Maria J. Gouveia, Gabriel Rinaldi, Júlio Santos, Lúcio Lara Santos, Paul J. Brindley, José M.Correia da Costa

*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygl adolyguadolygiad gan gymheiriaid

12 Dyfyniadau(SciVal)

Crynodeb

Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large.

Iaith wreiddiolSaesneg
CyfnodolynTumor Biology
Cyfrol39
Rhif cyhoeddi3
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 01 Maw 2017
Cyhoeddwyd yn allanolIe

Ôl bys

Gweld gwybodaeth am bynciau ymchwil 'The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

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