Toward automatic reconstruction of a highly resolved tree of life

Francesca D Ciccarelli; Tobias Doerks; Christian von Mering; Christopher J Creevey; Berend Snel; Peer Bork

doi:10.1126/science.1123061

Toward automatic reconstruction of a highly resolved tree of life

Francesca D Ciccarelli, Tobias Doerks, Christian von Mering, Christopher J Creevey, Berend Snel, Peer Bork

Gwyddorau Bywyd

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

362 Wedi eu Llwytho i Lawr (Pure)

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We have developed an automatable procedure for reconstructing the tree of life with branch lengths comparable across all three domains. The tree has its basis in a concatenation of 31 orthologs occurring in 191 species with sequenced genomes. It revealed interdomain discrepancies in taxonomic classification. Systematic detection and subsequent exclusion of products of horizontal gene transfer increased phylogenetic resolution, allowing us to confirm accepted relationships and resolve disputed and preliminary classifications. For example, we place the phylum Acidobacteria as a sister group of delta-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	1283-1287
Nifer y tudalennau	5
Cyfnodolyn	Science
Cyfrol	311
Rhif cyhoeddi	5765
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1126/science.1123061
Statws	Cyhoeddwyd - Maw 2006

Mynediad at Ddogfen

10.1126/science.1123061

Toward automatic reconstruction of a highly resolved tree of lifeLlawysgrif awdur wedi’i dderbyn, 1.59 MB

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http://hdl.handle.net/2160/26318

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title = "Toward automatic reconstruction of a highly resolved tree of life",

abstract = "We have developed an automatable procedure for reconstructing the tree of life with branch lengths comparable across all three domains. The tree has its basis in a concatenation of 31 orthologs occurring in 191 species with sequenced genomes. It revealed interdomain discrepancies in taxonomic classification. Systematic detection and subsequent exclusion of products of horizontal gene transfer increased phylogenetic resolution, allowing us to confirm accepted relationships and resolve disputed and preliminary classifications. For example, we place the phylum Acidobacteria as a sister group of delta-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor.",

author = "Ciccarelli, {Francesca D} and Tobias Doerks and {von Mering}, Christian and Creevey, {Christopher J} and Berend Snel and Peer Bork",

note = "Ciccarelli, F. D., Doerks, T., von Mering, C., Creevey, C. J., Snel, B., Bork, P. (2006). Toward automatic reconstruction of a highly resolved tree of life. Science, 311 (5765), 1283-1287",

year = "2006",

month = mar,

doi = "10.1126/science.1123061",

language = "English",

volume = "311",

pages = "1283--1287",

journal = "Science",

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T1 - Toward automatic reconstruction of a highly resolved tree of life

AU - Ciccarelli, Francesca D

AU - Doerks, Tobias

AU - von Mering, Christian

AU - Creevey, Christopher J

AU - Snel, Berend

AU - Bork, Peer

N1 - Ciccarelli, F. D., Doerks, T., von Mering, C., Creevey, C. J., Snel, B., Bork, P. (2006). Toward automatic reconstruction of a highly resolved tree of life. Science, 311 (5765), 1283-1287

PY - 2006/3

Y1 - 2006/3

N2 - We have developed an automatable procedure for reconstructing the tree of life with branch lengths comparable across all three domains. The tree has its basis in a concatenation of 31 orthologs occurring in 191 species with sequenced genomes. It revealed interdomain discrepancies in taxonomic classification. Systematic detection and subsequent exclusion of products of horizontal gene transfer increased phylogenetic resolution, allowing us to confirm accepted relationships and resolve disputed and preliminary classifications. For example, we place the phylum Acidobacteria as a sister group of delta-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor.

AB - We have developed an automatable procedure for reconstructing the tree of life with branch lengths comparable across all three domains. The tree has its basis in a concatenation of 31 orthologs occurring in 191 species with sequenced genomes. It revealed interdomain discrepancies in taxonomic classification. Systematic detection and subsequent exclusion of products of horizontal gene transfer increased phylogenetic resolution, allowing us to confirm accepted relationships and resolve disputed and preliminary classifications. For example, we place the phylum Acidobacteria as a sister group of delta-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor.

UR - http://hdl.handle.net/2160/26318

U2 - 10.1126/science.1123061

DO - 10.1126/science.1123061

M3 - Article

C2 - 16513982

SN - 0036-8075

VL - 311

SP - 1283

EP - 1287

JO - Science

JF - Science

IS - 5765

ER -

Toward automatic reconstruction of a highly resolved tree of life

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