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Amanda is a member of the Ser Cymru team within the Centre for Excellence in Bovine Tuberculosis based in Carwyn James Building.
Her current research activities surround the understanding of host-pathogen interaction at the very early stages of infection leading to disease progression – specifically to investigate the interaction of M. bovis with the innate immune system of the bovine host. Amanda's research activities are supported by a strong background in immunology and most recently comprehensive training in mycobacteriology.
Centre for Excellence in Bovine Tuberculosis research program is underpinned by 3 main themes:
- Fundamental understanding of early innate immune events leading to infectious disease
- Understanding the role of Mycobacterial genetic strain diversity on immune interaction and disease progression
- Development of novel paired diagnostics and vaccine technologies
Keywords
- QR180 Immunology
- Innate Immunology
- Antigen Presenting Cells
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 14 Life Below Water -
SDG 15 Life on Land
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Collaborations and top research areas from the last five years
Profiles
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Madison Cara Wade
Person: Doctor of Philosophy
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Commentary on the potential effects of infection with Mycobacterium bovis during the first days of life on the immune response to, and performance of diagnostics for the detection of, infection with M. bovis
Gibson, A. J., Hopkins, B., Hewinson, R. G. & Villarreal-Ramos, B., 31 May 2026, In: Tuberculosis. 158, 102749.Research output: Contribution to journal › Comment/Debate › peer-review
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Workshop report: One Health challenges and knowledge gaps in the control of intracellular infections with a focus on tuberculosis and leishmaniasis
VALIDATE Network One Health Working Group, Miller, M., Gómez, M. A., Tanner, R., Vermaak, S. & Villarreal-Ramos, B., 19 Apr 2025, In: Vaccine. 53, 9 p., 126929.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)9 Downloads (Pure) -
Respiratory bioenergetics is enhanced in human, but not bovine macrophages after exposure to M. bovis PPD: Exploratory insights into overall similar Cellular Metabolic Profiles
Bartens, M. C., Willcocks, S., Werling, D. & Gibson, A. J., 30 Nov 2024, In: Innate Immunity. 30, 6-8, p. 136-149 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
Characterisation of the bovine C-type lectin receptor Mincle and potential evidence for an endogenous ligand
Holder, A., Kolakowski, J., Rosentreter, C., Knuepfer, E., Jégouzo, S. A. F., Rosenwasser, O., Harris, H., Baumgaertel, L., Gibson, A. & Werling, D., 19 May 2023, In: Frontiers in Immunology. 14, 14 p., 1189587.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)134 Downloads (Pure) -
Detecting mecA in Faecal Samples: A Tool for Assessing Carriage of Meticillin-Resistant Staphylococci in Pets and Owners in the Microbiological ‘Fast Age’?
Frosini, S.-M., Gallow, G., Gibson, A., Menezes, J., Pomba, C. & Loeffler, A., 13 Jan 2023, In: Microbiology Research. 14, 1, p. 60-66 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Downloads (Pure) -
Defining the Genes Required for Survival of Mycobacterium bovis in the Bovine Host Offers Novel Insights into the Genetic Basis of Survival of Pathogenic Mycobacteria
Gibson, A., Stiens, J., Passmore, I., Faulkner, V., Miculob, J., Willcocks, S., Coad, M., Berg, S., Werling, D., Wren, B., Nobeli, I., Villarreal-Ramos, B. & Kendall, S. L., 30 Aug 2022, In: mBio. 13, 4, 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)179 Downloads (Pure) -
In Vitro Supplementation of Copper Modulates the Functional Th1/Th2 Phenotype of Peripheral Blood Mononuclear Cells in Cattle
Bunting, M., Challice, B., Gibson, A. & van Winden, S., 19 Sept 2021, In: Animals. 11, 9, 11 p., 2739.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Probing Differences in Gene Essentiality Between the Human and Animal Adapted Lineages of the Mycobacterium tuberculosis Complex Using TnSeq
Gibson, A. J., Passmore, I. J., Faulkner, V., Xia, D., Nobeli, I., Stiens, J., Willcocks, S., Clark, T. G., Sobkowiak, B., Werling, D., Villarreal-Ramos, B., Wren, B. W. & Kendall, S. L., 24 Dec 2021, In: Frontiers in Veterinary Science. 8, 12 p., 760717.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus) -
Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits
Faulkner, V., Cox, A. A., Goh, S., van Bohemen, A., Gibson, A. J., Liebster, O., Wren, B. W., Willcocks, S. & Kendall, S. L., 01 Feb 2021, In: Frontiers in Microbiology. 11, 10 p., 619427.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)137 Downloads (Pure) -
Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed and Species-Specific Innate Immune Functionality
Bartens, M. C., Gibson, A. J., Etherington, G. J., Di Palma, F., Holder, A., Werling, D. & Willcocks, S., 23 Dec 2021, In: Frontiers in Immunology. 12, 14 p., 764390.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus) -
The Role of TLR2 and TLR4 in Recognition and Uptake of the Apicomplexan Parasite Eimeria bovis and Their Effects on NET Formation
Muñoz-Caro, T., Gibson, A. J., Conejeros, I., Werling, D., Taubert, A. & Hermosilla, C., 24 Jan 2021, In: Pathogens. 10, 2, 15 p., 118.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)128 Downloads (Pure)
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TB Biosensor: A Novel, Real-Time Tuberculosis Detector for Animals and Humans
Finlayson, C. (Project Lead), Copner, N. (Project Co‑Lead), Gibson, A. (Project Co‑Lead), Hewinson, G. (Project Co‑Lead) & Jones, H. (Technician)
01 Feb 2025 → 31 Jan 2027
Project: Externally funded research
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ATAL TB: North Wales bTB Control and Protect Programme Through Local Leaders
Hewinson, G. (Project Lead), Gibson, A. (Project Co‑Lead), Payne, S. (Project Co‑Lead), Healey, A. (Research and Innovation Associate), Hopkins, B. (Research and Innovation Associate), Parsons, K. (Research and Innovation Associate) & Jones, H. (Technician)
17 Dec 2024 → 31 Mar 2027
Project: Externally funded research
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ATAL TB (2): Funding Package #2 (addit funds for WT460626) : North Wales bTB Control and Protect Programme Through Local Leaders
Hewinson, G. (Project Lead), Gibson, A. (Project Co‑Lead), Hopkins, B. (Project Co‑Lead), Payne, S. (Project Co‑Lead), Payne, S. (Project Co‑Lead), Parsons, K. (Research and Innovation Associate) & Longworth, J. (Technician)
01 Jun 2025 → 31 Mar 2026
Project: Externally funded research
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Welsh Gov Sample Service
Sayce, J. (Project Lead), Gibson, A. (Project Co‑Lead), Hewinson, G. (Project Co‑Lead), Sayce, J. (Project Manager) & Jones, H. (Technician)
Llywodraeth Cymru | Welsh Government
01 Apr 2025 → 31 Mar 2026
Project: Infrastructure & Equipment
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Effect of surface termination on the cellular internalization pathways of nanodiamonds in monocytic cells
Cross, R. (Project Lead) & Gibson, A. (Project Lead)
The Joy Welch Educational Charitable Trust
01 Sept 2023 → 30 Jun 2024
Project: Internally funded research
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Using RNA-seq to investigate the functional impact of a novel mutation circulating in the Welsh M. bovis population
Williams, C. (Project Lead) & Gibson, A. (Project Lead)
The Joy Welch Educational Charitable Trust
01 Aug 2023 → 01 May 2024
Project: Internally funded research
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Persistence of Mycobacterium bovis: Understanding the impact of persistent phenotypes on function - Beth Wilkinson
Gibson, A. (Project Lead)
Society for Applied Microbiology
01 Jul 2022 → 31 Aug 2022
Project: Externally funded research
Equipment
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Axiocam Primovert 208 Color Microscope with Camera
Gibson, A. (Manager)
VetHub1Facility/equipment: Equipment
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Axiocam Primovert 208 Color Microscope with Camera
Gibson, A. (Manager)
VetHub1Facility/equipment: Equipment
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Axiocam Primovert 208 Color Microscope with Camera
Gibson, A. (Manager)
VetHub1Facility/equipment: Equipment