Research output per year
Research output per year
Prof, PhD
Aberystwyth University
Edward Llwyd Building
Penglais
Aberystwyth
United Kingdom of Great Britain and Northern Ireland
Research activity per year
My research revolves around trying to answer this question: How can fundamental studies of developmental biology & gene regulation guide our search for next generation anthelmintic solutions?
Parasitic worms cause some of the most disfiguring, debilitating & chronic infectious diseases of human & animal populations across the globe. Reliance on limited drug classes to treat affected individuals & the lack of available vaccines to induce protective immunity suggests that current experimental approaches in identifying urgently needed anthelmintics have yet to deliver sustainable solutions.
Utilising both hypothesis-led & discovery driven research approaches my laboratory is developing new strategies for controlling parasitic helminths of biomedical importance. Our area of expertise is Schistosoma mansoni, one of the three main trematode species responsible for the neglected tropical disease Schistosomiasis. More than 200 million people suffer from this chronic & debilitating disease, with 90% of all worldwide cases found in poverty-stricken areas of sub-Saharan Africa where up to 300,000 individuals die each year. Praziquantel is currently used to treat schistosomiasis, but the need for repetitive treatment in endemic communities, concerns over the development of resistance & an unknown mechanism of action all have contributed to the active search for new chemotherapeutic agents or a prophylactic vaccine.
To identify next generation anthelmintics we look for solutions in the interrelated disciplines of helminth developmental biology, epigenetics & gene regulation. Our research includes individual-gene & (epi) genome-wide investigations, supported by experimental models of schistosome infection & objective analyses of helminth viability & phenotype. We envision that our integrated approach will enable progress to be made against an intractable disease affecting some of the most disadvantaged populations of the developing world.
PROJECT WEBPAGES:
Flatworm Functional Genomics Initiative (FUGI): www.sanger.ac.uk/science/collaboration/flatworm-functional-genomics-initiative-fugi
Barrett Centre for Helminth Control (BCHC): https://bchc.aber.ac.uk
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Person: Doctor of Philosophy
Person: Doctor of Philosophy
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Padalino, G., Chalmers, I., Brancale, A. & Hoffmann, K., figshare, 23 Jun 2020
DOI: 10.6084/m9.figshare.12473108, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12473108
Dataset
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I., Brancale, A., Grunau, C. & Hoffmann, K., figshare, 04 Jan 2023
DOI: 10.6084/m9.figshare.21814623
Dataset
Padalino, G., Chalmers, I., Brancale, A. & Hoffmann, K., figshare, 23 Jun 2020
DOI: 10.6084/m9.figshare.12546449, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12546449/2
Dataset
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., A Cole, P., Lassalle, D., Forde-Thomas, J., Chalmers, I., Brancale, A., Grunau, C. & Hoffmann, K., figshare, 05 Mar 2023
DOI: 10.6084/m9.figshare.21814710
Dataset
01 Oct 2021 → 31 Mar 2024
Project: Externally funded research
01 Oct 2020 → 31 Dec 2023
Project: Externally funded research
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
30 Jun 2018 → 30 Sept 2018
Project: Externally funded research
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
30 Jun 2018 → 30 Sept 2018
Project: Externally funded research
The Joy Welch Educational Charitable Trust
01 Jul 2017 → 31 Jul 2017
Project: Externally funded research
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
01 May 2017 → 31 Mar 2018
Project: Externally funded research
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
18 May 2016 → 17 May 2017
Project: Externally funded research
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
01 Apr 2016 → 30 Jun 2016
Project: Externally funded research
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
01 Oct 2015 → 30 Sept 2018
Project: Externally funded research
16 Jan 2019
1 Media contribution
Press/Media: Media contribution
28 Jun 2018 → 29 Jun 2018
2 Media contributions
Press/Media: Media contribution
23 Jun 2017
1 Media contribution
Press/Media: Media contribution
Karl Hoffmann (Participant)
Activity: Participating in or organising an event › Workshop, Seminar, or Course
Karl Hoffmann (Participant)
Activity: Participating in or organising an event › Conference
Karl Hoffmann (Participant)
Activity: Participating in or organising an event › Conference
Karl Hoffmann (Visiting researcher)
Activity: Visiting an external institution › Visiting an external academic institution
Karl Hoffmann (Visiting researcher)
Activity: Visiting an external institution › Visiting an external academic institution
Kathrin Karola Geyer (Participant), Kezia Whatley (Participant) & Karl Hoffmann (Participant)
Activity: Participating in or organising an event › Conference
Karl Hoffmann (Organiser)
Activity: Participating in or organising an event › Workshop, Seminar, or Course
Karl Hoffmann (Participant)
Activity: Participating in or organising an event › Workshop, Seminar, or Course
Karl Hoffmann (Host)
Activity: Hosting a visitor › Hosting an academic visitor
Karl Hoffmann (Participant)
Activity: Participating in or organising an event › Conference
Hoffmann, Karl (Recipient), 2009
Prize: Prize (including medals and awards)