Research output per year
Research output per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Profiles
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Eilis Rose Begley
Person: Doctor of Philosophy
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Carla Gustave
Person: Doctor of Philosophy
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Brenda Kisia Odhiambo
Person: Doctor of Philosophy
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Anthelmintic evaluation of triterpenes derived from conifers (family Pinaceae) on the digenean parasite Fasciola hepatica
Chakroborty, A., Dankwa, B., Crusco, A., Forde-Thomas, J. E., Abeysekara, S., Kiwanuka, Z., Ley, M., Davey, S. D., Hollinshead, J., Bartholomew, B., Wild, C., Fenn, C., Thomas, D. A., Holdsworth, P., Fisher, M., Baird, M. S., Nash, R. J. & Hoffmann, K. F., 30 Sept 2025, In: Fitoterapia. 185, 11 p., 106762.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
Glycan remodelling of live adult Schistosoma mansoni worms by chemical inhibition of α-mannosidases☆
Kuhlemaijer, E. B., Veldhuizen, T., van Hulst, I. A., Liesker, T., Hulme, B. J., Forde-Thomas, J. E., Rinaldi, G., Hoffmann, K. F., van Diepen, A. & Hokke, C. H., 19 Nov 2025, (E-pub ahead of print) In: International Journal for Parasitology.Research output: Contribution to journal › Article › peer-review
Open Access -
Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity
Rawat, M., Padalino, G., Adika, E., Okombo, J., Yeo, T., Brancale, A., Fidock, D. A., Hoffmann, K. F. & Lee, M. C. S., 03 Feb 2025, In: PLoS Pathogens. 21, 2, 23 p., e1012216.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)5 Downloads (Pure) -
Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery
Poon, V., Bailey, C., Carvalho, S., Patterson, S., Fyfe, J. W. B., Semenova, O., Wrigley, S. K., Hopkins, E., Manohar, R., Drake, C., Kokubun, T., Boyle, J., Kvaerno, L., Lees, K., Hoffmann, K. F., Forde-Thomas, J., Wyllie, S., Steele, J., Gilbert, I. H. & Tarver, G. J., 23 Oct 2025, In: Journal of Medicinal Chemistry. 68, 20, p. 21479-21488 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms
Padalino, G., Duggan, K., Mur, L. A. J., Maillard, J.-Y., Brancale, A. & Hoffmann, K. F., 01 Dec 2024, In: MicrobiologyOpen. 13, 6, e011.Research output: Contribution to journal › Comment/Debate
Open AccessFile1 Citation (Scopus)5 Downloads (Pure) -
Gut microbiota and immune profiling of microbiota-humanised versus wildtype mouse models of hepatointestinal schistosomiasis
Stark, K. A., Rinaldi, G., Costain, A., Clare, S., Tolley, C., Almeida, A., McCarthy, C., Harcourt, K., Brandt, C., Lawley, T. D., Berriman, M., MacDonald, A. S., Forde-Thomas, J. E., Hulme, B. J., Hoffmann, K. F., Cantacessi, C. & Cortés, A., 01 Dec 2024, In: Animal Microbiome. 6, 1, 19 p., 36.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)4 Downloads (Pure) -
Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity
Rawat, M., Padalino, G., Yeo, T., Brancale, A., Fidock, D. A., Hoffmann, K. F. & Lee, M. C. S., 24 Apr 2024, bioRxiv.Research output: Working paper › Preprint
Open AccessFile12 Downloads (Pure) -
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes
Padalino, G., Celatka, C., Rienhoff Jr., H. Y., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I., Brancale, A., Grunau, C. & Hoffmann, K., 30 Mar 2023, In: Wellcome Open Research. 8, 146, 33 p., 146.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)68 Downloads (Pure) -
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
Chakroborty, A., Pritchard, D., Bouillon, M. E., Cervi, A., Kraehenbuehl, R., Wild, C., Fenn, C., Holdsworth, P. A., Capner, C., Padalino, G., Forde-Thomas, J., Payne, J., Smith, B. G., Fisher, M., Lahmann, M., Baird, M. S. & Hoffmann, K., 03 Jul 2023, In: Pharmaceutics. 15, 7, 15 p., 1869.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)67 Downloads (Pure) -
Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022
Caldwell, N., Afshar, R., Baragaña, B., Bustinduy, A. L., Caffrey, C. R., Collins, J. J., Fusco, D., Garba, A., Gardner, M., Gomes, M., Hoffmann, K. F., Hsieh, M., Lo, N. C., McNamara, C. W., Nono, J. K., Padalino, G., Read, K. D., Roestenberg, M., Spangenberg, T. & Specht, S. & 1 others, , 12 May 2023, In: ACS Infectious Diseases. 9, 5, p. 1046-1055 10 p.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile28 Citations (Scopus)98 Downloads (Pure) -
Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis
Houlder, E. L., Costain, A. H., Nambuya, I., Brown, S. L., Koopman, J. P. R., Langenberg, M. C. C., Janse, J. J., Hoogerwerf, M. A., Ridley, A. J. L., Forde-Thomas, J. E., Colombo, S. A. P., Winkel, B. M. F., Galdon, A. A., Hoffmann, K. F., Cook, P. C., Roestenberg, M., Mpairwe, H. & MacDonald, A. S., 03 Apr 2023, In: Nature Communications. 14, 1, 12 p., 1863.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)162 Downloads (Pure)
Datasets
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Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Underlying data
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K., Figshare, 23 Jun 2020
DOI: 10.6084/m9.figshare.12473108, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12473108
Dataset
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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary tables and movies
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I. W., Brancale, A., Grunau, C. & Hoffmann, K. F., Figshare, 04 Jan 2023
DOI: 10.6084/m9.figshare.21814623
Dataset
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Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Extended data
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K., Figshare, 23 Jun 2020
DOI: 10.6084/m9.figshare.12546449, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12546449/2
Dataset
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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., A Cole, P., Lassalle, D., Forde-Thomas, J., Chalmers, I. W., Brancale, A., Grunau, C. & Hoffmann, K. F., Figshare, 05 Mar 2023
DOI: 10.6084/m9.figshare.21814710
Dataset
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WORMVACS2.0 - *UKRI Guarantee Fund*
Hoffmann, K. (PI)
01 Sept 2023 → 31 Aug 2028
Project: Externally funded research
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MoA 13400A-01: 2-month Extension
Hoffmann, K. (PI)
01 Apr 2025 → 31 May 2025
Project: Externally funded research
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Refining the Drug Discovery Paradigm for Schistosomiasis
Hoffmann, K. (PI)
01 Oct 2021 → 31 Mar 2024
Project: Externally funded research
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FIP A New Plant Derived Flukicide
Hoffmann, K. (PI)
01 Oct 2021 → 30 Sept 2023
Project: Externally funded research
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A platform for drug target deconvolution and exploitation
Hoffmann, K. (PI)
01 Oct 2020 → 31 Dec 2023
Project: Externally funded research
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Roboworm 4: Development of a mobility image abalysis model for newly excysted juvenile Fasciola hepatica
Hoffmann, K. (PI)
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
30 Jun 2018 → 30 Sept 2018
Project: Externally funded research
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ADME/ toxicology analyses of lead Schitosoma mansoni histone methyltransferase HMT inhibitors
Hoffmann, K. (PI)
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
30 Jun 2018 → 30 Sept 2018
Project: Externally funded research
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Exploring G-Quadruplexes in Schistosoma mansoni
Hoffmann, K. (PI)
SSN Educational and Charitable Trust
01 Jul 2017 → 31 Jul 2017
Project: Externally funded research
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Roboworm 3- BRIDGING FUND
Hoffmann, K. (PI)
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
01 May 2017 → 31 Mar 2018
Project: Externally funded research
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Hit Discovery for Schistosomiasis
Hoffmann, K. (PI)
01 Jul 2016 → 30 Jun 2019
Project: Externally funded research
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CLOSED. Roboworm 2: an automated high content imaging platform for repositioning old drugs (Roboworm 1, 11880)
Hoffmann, K. (PI)
Rhwydwaith Gwyddorau Bywyd Cymru | Life Sciences Research Network Wales
18 May 2016 → 17 May 2017
Project: Externally funded research
Impacts
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Advise Public Health Wales on Swimmer's Itch
Hoffmann, K. (Researcher)
Impact: Health and welfare - new products, guidelines and services, Economy, commerce and organisations
Press/Media
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Queen presents award to Aberystwyth University for parasite research
23 Feb 2024
2 items of Media coverage
Press/Media: Media coverage
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The Queen Presents Award to Aberystwyth University for Parasite Research
22 Feb 2024
1 item of Media coverage
Press/Media: Media coverage
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Aberystwyth University academics to develop a vaccine for parasitic diseases
24 Nov 2023
1 item of Media coverage
Press/Media: Media coverage
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Aberystwyth University Researchers Reveal New Findings on Nucleoproteins [Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes [version 1; peer review: 2 approved]]
Forde-Thomas, J., Hoffmann, K. & Chalmers, I.
10 Aug 2023
1 item of Media coverage
Press/Media: Media coverage
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Tropical Disease Research Boosted With 'Future Leader' Joining Aberystwyth University
16 Jun 2022
1 item of Media coverage
Press/Media: Media coverage
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New funding to boost deadly disease research
20 Jan 2022
1 item of Media coverage
Press/Media: Media coverage
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Gene-editing tool shown to limit impact of certain parasitic diseases
16 Jan 2019
1 Media contribution
Press/Media: Media contribution
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Collaboration to combat deadly diseases
30 Nov 2018
1 Media contribution
Press/Media: Media contribution
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Parasitic flatworms affect millions in developing countries, but new research offers hope
28 Jun 2018 → 29 Jun 2018
2 Media contributions
Press/Media: Media contribution
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Snail study combats deadly tropical disease
23 Jun 2017
1 Media contribution
Press/Media: Media contribution
Activities
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Scientific seminar delivered to staff and students at Leiden University Medical Center, the Netherlands,
Hoffmann, K. (Participant)
2017Activity: Participating in or organising an event › Workshop, Seminar, or Course
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Life Sciences Research Network Wales
Hoffmann, K. (Participant)
30 Nov 2016 → 01 Dec 2016Activity: Participating in or organising an event › Conference
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Keystone Symposia
Hoffmann, K. (Participant)
24 Jan 2016 → 26 Jan 2016Activity: Participating in or organising an event › Conference
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University of Manchester
Hoffmann, K. (Visiting researcher)
2016Activity: Visiting an external institution › Visiting an external academic institution
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Liverpool School of Tropical Medicine
Hoffmann, K. (Visiting researcher)
2016Activity: Visiting an external institution › Visiting an external academic institution
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International Flatworm Biology Symposium
Geyer, K. K. (Participant), Whatley, K. (Participant) & Hoffmann, K. (Participant)
03 Aug 2015Activity: Participating in or organising an event › Conference
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TheSchistoVac Final Meeting
Hoffmann, K. (Organiser)
29 Jun 2015Activity: Participating in or organising an event › Workshop, Seminar, or Course
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UK Innovate Grant Workshop
Hoffmann, K. (Participant)
29 Jan 2015Activity: Participating in or organising an event › Workshop, Seminar, or Course
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Cardiff University
Hoffmann, K. (Host)
Jan 2015 → Apr 2015Activity: Hosting a visitor › Hosting an academic visitor
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Life Sciences Research Network Wales - 1st Annual Scientific Congress 2014
Hoffmann, K. (Participant)
23 Nov 2014Activity: Participating in or organising an event › Conference
Prizes
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Queen’s Anniversary Prize 2023
Brophy, P. (Recipient), Hamilton, J. (Recipient), Hoffmann, K. (Recipient), Jones, R. (Recipient), Chalmers, I. (Recipient), Morphew, R. (Recipient), Rinaldi, G. (Recipient), Williams, H. (Recipient) & Barber, I. (Recipient), 2023
Prize: Prize (including medals and awards)
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Research prize - Sandler Center for Parasitological Research
Hoffmann, K. (Recipient), 2009
Prize: Prize (including medals and awards)