Karl Hoffmann

2024

Gut microbiota and immune profiling of microbiota-humanised versus wildtype mouse models of hepatointestinal schistosomiasis

Stark, K. A., Rinaldi, G., Costain, A., Clare, S., Tolley, C., Almeida, A., McCarthy, C., Harcourt, K., Brandt, C., Lawley, T. D., Berriman, M., MacDonald, A. S., Forde-Thomas, J. E., Hulme, B. J., Hoffmann, K. F., Cantacessi, C. & Cortés, A., 01 Dec 2024, In: Animal Microbiome. 6, 1, 36.

Research output: Contribution to journal › Article › peer-review

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Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity

Rawat, M., Padalino, G., Yeo, T., Brancale, A., Fidock, D. A., Hoffmann, K. F. & Lee, M. C. S., 24 Apr 2024, bioRxiv.

Research output: Working paper › Preprint

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5 Downloads (Pure)

2023

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

Padalino, G., Celatka, C., Rienhoff Jr., H. Y., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I., Brancale, A., Grunau, C. & Hoffmann, K., 30 Mar 2023, In: Wellcome Open Research. 8, 146, 29 p., 146.

Research output: Contribution to journal › Article › peer-review

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1 Citation (Scopus)

70 Downloads (Pure)

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

Chakroborty, A., Pritchard, D., Bouillon, M. E., Cervi, A., Kraehenbuehl, R., Wild, C., Fenn, C., Holdsworth, P. A., Capner, C., Padalino, G., Forde-Thomas, J., Payne, J., Smith, B. G., Fisher, M., Lahmann, M., Baird, M. S. & Hoffmann, K., 03 Jul 2023, In: Pharmaceutics. 15, 7, 15 p., 1869.

Research output: Contribution to journal › Article › peer-review

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1 Citation (Scopus)

105 Downloads (Pure)

Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

Caldwell, N., Afshar, R., Baragaña, B., Bustinduy, A. L., Caffrey, C. R., Collins, J. J., Fusco, D., Garba, A., Gardner, M., Gomes, M., Hoffmann, K. F., Hsieh, M., Lo, N. C., McNamara, C. W., Nono, J. K., Padalino, G., Read, K. D., Roestenberg, M., Spangenberg, T. & Specht, S. & 1 others, Gilbert, I. H., 12 May 2023, In: ACS Infectious Diseases. 9, 5, p. 1046-1055 10 p.

Research output: Contribution to journal › Review Article › peer-review

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12 Citations (Scopus)

90 Downloads (Pure)

Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis

Houlder, E. L., Costain, A. H., Nambuya, I., Brown, S. L., Koopman, J. P. R., Langenberg, M. C. C., Janse, J. J., Hoogerwerf, M. A., Ridley, A. J. L., Forde-Thomas, J. E., Colombo, S. A. P., Winkel, B. M. F., Galdon, A. A., Hoffmann, K. F., Cook, P. C., Roestenberg, M., Mpairwe, H. & MacDonald, A. S., 01 Dec 2023, In: Nature Communications. 14, 1, 12 p., 1863.

Research output: Contribution to journal › Article › peer-review

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4 Citations (Scopus)

166 Downloads (Pure)

Small Molecule Ligands of the BET-like Bromodomain, SmBRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development

Schiedel, M., McArdle, D. J. B., Padalino, G., Chan, A. K. N., Forde-Thomas, J., McDonough, M., Whiteland, H., Beckmann, M., Cookson, R., Hoffmann, K. F. & Conway, S. J., 14 Dec 2023, In: Journal of Medicinal Chemistry. 66, 23, p. 15801-15822 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility

White, R., Sotillo, J., Ancarola, M. E., Borup, A., Boysen, A. T., Brindley, P. J., Buzás, E. I., Cavallero, S., Chaiyadet, S., Chalmers, I. W., Cucher, M. A., Dagenais, M., Davis, C. N., Devaney, E., Duque-Correa, M. A., Eichenberger, R. M., Fontenla, S., Gasan, T. A., Hokke, C. H. & Kosanovic, M. & 22 others, Kuipers, M. E., Laha, T., Loukas, A., Maizels, R. M., Marcilla, A., Mazanec, H., Morphew, R. M., Neophytou, K., Nguyen, L. T., Nolte-'t Hoen, E., Povelones, M., Robinson, M. W., Rojas, A., Schabussova, I., Smits, H. H., Sungpradit, S., Tritten, L., Whitehead, B., Zakeri, A., Nejsum, P., Buck, A. H. & Hoffmann, K. F., 05 Jan 2023, In: Journal of Extracellular Vesicles. 12, 1, 16 p., 12298.

Research output: Contribution to journal › Article › peer-review

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21 Citations (Scopus)

92 Downloads (Pure)

Using ChEMBL to Complement Schistosome Drug Discovery

Padalino, G., Coghlan, A., Pagliuca, G., Forde-Thomas, J., Berriman, M. & Hoffmann, K., 28 Apr 2023, In: Pharmaceutics. 15, 5, 26 p., 1359.

Research output: Contribution to journal › Article › peer-review

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2 Citations (Scopus)

48 Downloads (Pure)

2022

Flukicidal effects of abietane diterpenoid derived analogues against the food borne pathogen Fasciola hepatica.

Chakroborty, A., Pritchard, D., Bouillon, M. E., Cervi, A., Cookson, A., Wild, C., Fenn, C., Payne, J., Holdsworth, P., Capner, C., O'Neill, J., Padalino, G., Forde-Thomas, J., Gupta, S., Smith, B. G., Fisher, M., Lahmann, M., Baird, M. S. & Hoffmann, K. F., 01 Sept 2022, In: Veterinary Parasitology. 309, 9 p., 109766.

Research output: Contribution to journal › Article › peer-review

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2 Citations (Scopus)

98 Downloads (Pure)

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

Hulme, B. J., Geyer, K. K., Forde-Thomas, J. E., Padalino, G., Phillips, D. W., Ittiprasert, W., Karinshak, S. E., Mann, V. H., Chalmers, I. W., Brindley, P. J., Hokke, C. H. & Hoffmann, K. F., 13 Jan 2022, In: PLOS Pathogens. 18, 1, 35 p., e1009828.

Research output: Contribution to journal › Article › peer-review

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18 Citations (Scopus)

139 Downloads (Pure)

2021

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation

Padalino, G., El-Sakkary, N., Liu, L. J., Liu, C., Harte, D. S. G., Barnes, R. E., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A. T., Caffrey, C. R., Chalmers, I., Brancale, A. & Hoffmann, K. F., 15 Dec 2021, In: European Journal of Medicinal Chemistry. 226, 19 p., 113823.

Research output: Contribution to journal › Article › peer-review

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7 Citations (Scopus)

155 Downloads (Pure)

Daily rhythms in gene expression of the human parasite Schistosoma mansoni

Rawlinson, K. A., Reid, A. J., Lu, Z., Driguez, P., Wawer, A., Coghlan, A., Sankaranarayanan, G., Buddenborg, S. K., Soria, C. D., McCarthy, C., Holroyd, N., Sanders, M., Hoffmann, K. F., Wilcockson, D., Rinaldi, G. & Berriman, M., 02 Dec 2021, In: BMC Biology. 19, 1, p. 255 255.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni

Craven, H., Bonsignore, R., Lenis, V., Santi, N., Berrar, D., Swain, M., Whiteland, H., Casini, A. & Hoffmann, K., 18 Feb 2021, In: PLoS Neglected Tropical Diseases. 15, 2, 24 p., e0008770.

Research output: Contribution to journal › Article › peer-review

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6 Citations (Scopus)

150 Downloads (Pure)

Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout Schistosoma mansoni Infection

Webb, L. M., Phythian-Adams, A. T., Costain, A. H., Brown, S. L., Lundie, R. J., Forde-Thomas, J., Cook, P. C., Jackson-Jones, L. H., Marley, A. K., Smits, H. H., Hoffmann, K. F., Tait Wojno, E. D. & MacDonald, A. S., 31 Aug 2021, In: ImmunoHorizons. 5, 8, p. 721-732 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

Gasan, T. A., Kuipers, M. E., Roberts, G. H., Padalino, G., Forde-Thomas, J. E., Wilson, S., Wawrzyniak, J., Tukahebwa, E. M., Hoffmann, K. F. & Chalmers, I. W., 18 Nov 2021, In: PLoS Neglected Tropical Diseases. 15, 11, e0009981.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function

Perally, S., Geyer, K. K., Farani, P. S. G., Chalmers, I. W., Fernandez-Fuentes, N., Maskell, D. R., Hulme, B. J., Forde-Thomas, J., Phillips, D., Farias, L. P., Collins, J. J. & Hoffmann, K. F., 01 Mar 2021, In: International Journal for Parasitology. 51, 4, p. 251-261 11 p.

Research output: Contribution to journal › Article › peer-review

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6 Citations (Scopus)

103 Downloads (Pure)

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni

Partridge, F. A., Bataille, C. J. R., Forman, R., Marriott, A. E., Forde-Thomas, J., Häberli, C., Dinsdale, R. L., O'Sullivan, J. D. B., Willis, N. J., Wynne, G. M., Whiteland, H., Archer, J., Steven, A., Keiser, J., Turner, J. D., Hoffmann, K. F., Taylor, M. J., Else, K. J., Russell, A. J. & Sattelle, D. B., 14 May 2021, In: ACS Infectious Diseases. 7, 5, p. 1260-1274 15 p.

Research output: Contribution to journal › Article › peer-review

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10 Citations (Scopus)

446 Downloads (Pure)

2020

DC‐SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte‐derived dendritic cells

Kuipers, M. E., Nolte-‘t Hoen, E. N. M., van der Ham, A. J., Ozir-Fazalalikhan, A., Nguyen, D. L., de Korne, C. M., Koning, R. I., Tomes, J. J., Hoffmann, K. F., Smits, H. H. & Hokke, C. H., 01 Sept 2020, In: Journal of Extracellular Vesicles. 9, 1, 19 p., 1753420.

Research output: Contribution to journal › Article › peer-review

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46 Citations (Scopus)

110 Downloads (Pure)

Helminth extracellular vesicles: Great balls of wonder

Hoffmann, K. F., Hokke, C. H., Loukas, A. & Buck, A. H., 05 Aug 2020, In: International Journal for Parasitology. 50, 9, p. 621-622 2 p.

Research output: Contribution to journal › Editorial

5 Citations (Scopus)

Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities

Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K. F., 13 Nov 2020, In: Wellcome Open Research. 5, 37 p., 169.

Research output: Contribution to journal › Article › peer-review

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6 Citations (Scopus)

78 Downloads (Pure)

Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni

Wang, J., Paz, C., Padalino, G., Coghlan, A., Lu, Z., Gradinaru, I., Collins, J. N. R., Berriman, M., Hoffmann, K. F. & Collins, J. J., 25 Sept 2020, In: Science (New York, N.Y.). 369, 6511, p. 1649-1653 5 p., eabb7699.

Research output: Contribution to journal › Article › peer-review

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53 Citations (Scopus)

213 Downloads (Pure)

Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal

Whiteland, H., Crusco, A., Bloemberg, L. W., Tibble-Howlings, J., Forde-Thomas, J., Coghlan, A., Murphy, P. J. & Hoffmann, K. F., 19 Oct 2020, In: PLoS Neglected Tropical Diseases. 14, 10, 22 p., e0008630.

Research output: Contribution to journal › Article › peer-review

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5 Citations (Scopus)

231 Downloads (Pure)

The synthesis and glycosidase inhibitory activity of analogues of tiruchanduramine

Ashworth, Z. J. R., Bartholomew, B., Evans, D. M., Forde-Thomas, J., Hoffmann, K. F., Murdoch, R., Nash, R. J., Sharp, H., Whiteland, H. & Murphy, P. J., 19 Mar 2020, In: Heterocycles. 100, 4, p. 609-621 13 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

2019

Antischistosomal Properties of Sclareol and Its Heck-Coupled Derivatives: Design, Synthesis, Biological Evaluation and Untargeted Metabolomics

Crusco, A., Whiteland, H., Baptista, R., Forde-Thomas, J. E., Beckmann, M., Mur, L. A. J., Nash, R. J., Westwell, A. D. & Hoffmann, K. F., 12 Jul 2019, In: ACS Infectious Diseases. 5, 7, p. 1188-1199 12 p.

Research output: Contribution to journal › Article › peer-review

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27 Citations (Scopus)

521 Downloads (Pure)

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

Wannaporn, I., Mann, V., Karinshak, S., Coghlan, A., Rinaldi, G., Sankaranarayanan, G., Chaidee, A., Tanno, T., Kumkhaek, C., Prangtaworn, P., Mentink-Kane, M. M., Cochran, C. J., Driguez, P., Holroyd, N., Tracey, A., Rodpai, R., Everts, B., Hokke, C. H., Hoffmann, K. & Berriman, M. & 1 others, Brindley, P. J., 15 Jan 2019, In: eLife. 8, N/A, 27 p., e41337.

Research output: Contribution to journal › Article › peer-review

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74 Citations (Scopus)

207 Downloads (Pure)

Schistosoma mansoni venom allergen-like proteins: Phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

Farias, L. P., Chalmers, I. W., Perally, S., Rofatto, H. K., Jackson, C. J., Brown, M., Khouri, M. I., Barbosa, M. M. F., Hensbergen, P. J., Hokke, C. H., Leite, L. C. C. & Hoffmann, K. F., 01 Jul 2019, In: International Journal for Parasitology. 49, 8, p. 593-599 7 p.

Research output: Contribution to journal › Article › peer-review

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8 Citations (Scopus)

184 Downloads (Pure)

The anti-mycobacterial activity of a diterpenoid-like molecule operates through nitrogen and amino acid starvation

Crusco, A., Alves Baptista, R., Bhowmick, S., Beckmann, M., Mur, L., Westwell, A. D. & Hoffmann, K., 25 Jun 2019, In: Frontiers in Microbiology. 10, JUN, 1444.

Research output: Contribution to journal › Article › peer-review

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1 Citation (Scopus)

231 Downloads (Pure)

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Nov 2019, In: PLoS Neglected Tropical Diseases. 13, 11, 24 p., e0007693.

Research output: Contribution to journal › Article › peer-review

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21 Citations (Scopus)

235 Downloads (Pure)

2018

An Abeis procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni

Whiteland, H., Chakroborty, A., Forde-Thomas, J., Crusco, A., Cookson, A., Hollinshead, J., Fenn, C., Bartholomew, B., Holdsworth, P. A., Fisher, M., Nash, R. J. & Hoffmann, K., 01 Dec 2018, In: International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 465-474 10 p.

Research output: Contribution to journal › Article › peer-review

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26 Citations (Scopus)

176 Downloads (Pure)

Antibody Responses to Schistosoma mansoni Schistosomula Antigens

Egesa, M., Lubyayi, L., Jones, F. M., van Diepen, A., Chalmers, I., Tukahebwa, E. M., Bagaya, B. S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Elliot, A. M., Yazdanbakhsh, M., Wilson, S. & Cose, S., 28 Nov 2018, In: Parasite Immunology. 40, 12, e12591.

Research output: Contribution to journal › Article › peer-review

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7 Citations (Scopus)

154 Downloads (Pure)

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., 31 Dec 2018, In: International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 559-570 12 p.

Research output: Contribution to journal › Article › peer-review

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26 Citations (Scopus)

187 Downloads (Pure)

Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues

Crusco, A., Bordoni, C., Chakroborty, A., Whatley, K. C. L., Whiteland, H., Westwell, A. D. & Hoffmann, K., 25 May 2018, In: European Journal of Medicinal Chemistry. 152, N/A, p. 87-100 14 p.

Research output: Contribution to journal › Article › peer-review

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29 Citations (Scopus)

203 Downloads (Pure)

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni

Roquis, D., Taudt, A., Geyer, K., Padalino, G., Hoffmann, K., Holroyd, N., Berriman, M., Allaga, B., Chaparro, C., Grunau, C. & de Carvalho Augusto, R., 21 May 2018, In: PLOS Pathogens. 14, 5, 26 p., e1007066.

Research output: Contribution to journal › Article › peer-review

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35 Citations (Scopus)

179 Downloads (Pure)

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni

Geyer, K., Munshi, S. E., Whiteland, H., Fernandez-Fuentes, N., Phillips, D. & Hoffmann, K., 28 Jun 2018, In: PLOS Pathogens. 14, 6, e1007107.

Research output: Contribution to journal › Article › peer-review

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11 Citations (Scopus)

211 Downloads (Pure)

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J. M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M. & Beckham, C. & 362 others, Bedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borràs, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M., Brigstock, D. R., Brisson, A., Broekman, M. L. D., Bromberg, J. F., Bryl-Górecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzás, E. I., Byrd, J. B., Camussi, G., Carter, D. R. F., Caruso, S., Chamley, L. W., Chang, Y. T., Chaudhuri, A. D., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A. W., Coyle, B., Crescitelli, R., Criado, M. F., D’Souza-Schorey, C., Das, S., de Candia, P., De Santana, E. F., De Wever, O., del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A. P., Duarte, F. V., Duncan, H. M., Eichenberger, R. M., Ekström, K., EL Andaloussi, S., Elie-Caille, C., Erdbrügger, U., Falcón-Pérez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Försönits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gámez-Valero, A., Gardiner, C., Gärtner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C. I., Görgens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A. G. E., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S. I., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanović, M. M., Kovács, Á. F., Krämer-Albers, E. M., Krasemann, S., Krause, M., Kurochkin, I. V., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lässer, C., Laurent, L. C., Lavieu, G., Lázaro-Ibáñez, E., Le Lay, S., Lee, M. S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T. S., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Linē, A., Linnemannstöns, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lörincz, Á. M., Lötvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L. N., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L. K., McVey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Möller, A., Møller Jørgensen, M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Nolte-’t Hoen, E. N. M., Noren Hooten, N., O’Driscoll, L., O’Grady, T., O’Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C. H., Pink, R. C., Pisetsky, D. S., Pogge von Strandmann, E., Polakovicova, I., Poon, I. K. H., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M. I., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M. A., Rughetti, A., Russell, A. E., Saá, P., Sahoo, S., Salas-Huenuleo, E., Sánchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schøyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P. R. M., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sódar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Tosar, J. P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W. M., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J. C., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Vasconcelos, M. H., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, É., Verweij, F. J., Vestad, B., Viñas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H. M., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yáñez-Mó, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Žėkas, V., Zhang, J. Y., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D. & Zuba-Surma, E. K., 01 Jan 2018, In: Journal of Extracellular Vesicles. 7, 1, 1535750.

Research output: Contribution to journal › Article › peer-review

Open Access

7157 Citations (Scopus)

Schistosoma mansoni schistosomula antigens induce Th1/Pro-inflammatory cytokine responses

Egesa, M., Lubyayi, L., Tukahebwa, E. M., Bagaya, B. S., Chalmers, I., Wilson, S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Yazdanbakhsh, M., Labuda, L. A. & Cose, S., 28 Nov 2018, In: Parasite Immunology. 40, 12, e12592.

Research output: Contribution to journal › Article › peer-review

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17 Citations (Scopus)

144 Downloads (Pure)

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

Geyer, K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., Chaparro, C., Swain, M. & Hoffmann, K., 01 Aug 2018, In: International Journal for Parasitology: Drugs and Drug Resistance. 8, 2, p. 213-222 10 p.

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17 Citations (Scopus)

220 Downloads (Pure)

2017

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Cosseau, C., Wolkenhauer, O., Padalino, G., Geyer, K., Hoffmann, K. & Grunau, C., 01 Apr 2017, In: Trends in Parasitology. 33, 4, p. 285-294 10 p.

Research output: Contribution to journal › Review Article › peer-review

Open Access

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27 Citations (Scopus)

221 Downloads (Pure)

Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense

Nur-e-Alam, M., Yousaf, M., Ahmed, S., Al-Sheddi, E. S., Shah, I., Fazakerley, D., Bari, A., Ghabbour, H. A., Threadgill, M. D., Whatley, K., Hoffmann, K. & Al-Rehaily, A. J., 23 Jun 2017, In: Journal of Natural Products. 80, 6, p. 1900-1908 9 p.

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15 Citations (Scopus)

264 Downloads (Pure)

Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Egesa, M., Hoffmann, K., Hokke, C. H., Yazdanbakhsh, M. & Cose, S., 01 Dec 2017, In: Trends in Parasitology. 33, 12, p. 918-921 4 p., 1671.

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15 Citations (Scopus)

262 Downloads (Pure)

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S. E., Grunau, C., Yoshino, T. P. & Hoffmann, K., 16 May 2017, In: PLoS Neglected Tropical Diseases. 11, 5, 29 p., e0005246.

Research output: Contribution to journal › Article › peer-review

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34 Citations (Scopus)

231 Downloads (Pure)

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Adema, C. M., Hillier, L. W., Jones, C. S., Loker, E. S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L. R., Arican-Goktas, H. D., Assis, J. G., Baba, E. H., Baron, O. L., Bayne, C. J., Bickham-Wright, U., Biggar, K. K., Blouin, M., Bonning, B. C. & Botka, C. & 97 others, Bridger, J. M., Buckley, K. M., Buddenborg, S. K., Lima Caldeira, R., Carleton, J., Carvalho, O. S., Castillo, M. G., Chalmers, I. W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R. M., Cuesta-Astroz, Y., Cummins, S. F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S. G., Geusz, M., Geyer, K. K., Giraldo-Calderón, G. I., de Souza Gomes, M., Gordy, M. A., Gourbal, B., Grunau, C., Hanington, P. C., Hoffmann, K. F., Hughes, D., Humphries, J., Jackson, D. J., Jannotti-Passos, L. K., De Jesus Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J. M., Kohn, A. B., Lawson, D., Lawton, S. P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A. E., Lovato, T. L., Ludolf, F., Magrini, V., Mcmanus, D. P., Medina, M., Misra, M., Mitta, G., Mkoji, G. M., Montague, M. J., Montelongo, C., Moroz, L. L., Munoz-Torres, M. C., Niazi, U., Noble, L. R., Oliveira, F. S., Pais, F. S., Papenfuss, A. T., Peace, R., Pena, J. J., Pila, E. A., Quelais, T., Raney, B. J., Rast, J. P., Rollinson, D., Rosse, I. C., Rotgans, B., Routledge, E. J., Ryan, K. M., Scholte, L. L. S., Storey, K. B., Swain, M., Tennessen, J. A., Tomlinson, C., Trujillo, D. L., Volpi, E. V., Walker, A. J., Wang, T., Wannaporn, I., Warren, W. C., Wu, X.-J., Yoshino, T. P., Yusuf, M., Zhang, S.-M., Zhao, M. & Wilson, R. K., 16 May 2017, In: Nature Communications. 8, p. 15451 15451.

Research output: Contribution to journal › Article › peer-review

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189 Citations (Scopus)

179 Downloads (Pure)

2016

DISMISS: MeDIP-seq: High-throughput sequencing

Niazi, U. (Developer), Geyer, K. (Developer), Vickers, M. (Developer), Hoffmann, K. (Developer) & Swain, M. (Developer), 02 Aug 2016

Research output: Non-textual form › Software

Open Access

DISMISS: Detection of stranded methylation in MeDIP-Seq data

Niazi, U., Geyer, K. K., Vickers, M. J., Hoffmann, K. & Swain, M., 29 Jul 2016, In: BMC Bioinformatics. 17, 1, 295.

Research output: Contribution to journal › Article › peer-review

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8 Citations (Scopus)

179 Downloads (Pure)

2015

Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7

Reimers, N., Homann, A., Höschler, B., Langhans, K., Wilson, R. A., Pierrot, C., Khalife, J., Grevelding, C. G., Chalmers, I. W., Yazdanbakhsh, M., Hoffmann, K. F., Hokke, C. H., Haas, H. & Schramm, G., 16 Mar 2015, In: PLoS Neglected Tropical Diseases. 9, 3, e0003593.

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26 Citations (Scopus)

185 Downloads (Pure)

Glycomic analysis of life stages of the human parasite Schistosoma mansoni reveals developmental expression profiles of functional and antigenic glycan motifs

Smit, C. H., van Diepen, A., Nguyen, D. L., Wuhrer, M., Hoffmann, K. F., Deelder, A. M. & Hokke, C. H., 01 Jul 2015, In: Molecular and Cellular Proteomics. 14, 7, p. 1750-1769 20 p.

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78 Citations (Scopus)

167 Downloads (Pure)

Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment

Chalmers, I. W., Fitzsimmons, C. M., Brown, M., Pierrot, C., Jones, F. M., Wawrzyniak, J. M., Fernandez-Fuentes, N., Tukahebwa, E. M., Dunne, D. W., Khalife, J. & Hoffmann, K. F., Jul 2015, In: PLoS Neglected Tropical Diseases. 9, 7, p. e0003920 e0003920.

Research output: Contribution to journal › Article › peer-review

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14 Citations (Scopus)

205 Downloads (Pure)

Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

Nowacki, F. C., Swain, M. T., Klychnikov, O. I., Niazi, U., Ivens, A., Quintana, J. F., Hensbergen, P. J., Hokke, C. H., Buck, A. H. & Hoffmann, K. F., 05 Oct 2015, In: Journal of Extracellular Vesicles. 4, 1, 28665.

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131 Citations (Scopus)

194 Downloads (Pure)

Sharing expertise/data/reagents

Hoffmann, K., 28 Oct 2015, Accelerating R&D for Neglected Diseases through Global Collaborations: WIPO Re:Search Partnership Stories 2013-2015. 2nd ed. Seattle, USA: BIO Ventures for Global Health, p. 23

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Open Access

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Karl Hoffmann

Research output

Search results