Karl Hoffmann

2025

Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity

Rawat, M., Padalino, G., Adika, E., Okombo, J., Yeo, T., Brancale, A., Fidock, D. A., Hoffmann, K. F. & Lee, M. C. S., 03 Feb 2025, In: PLoS Pathogens. 21, 2, 23 p., e1012216.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Downloads (Pure)

2024

Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms

Padalino, G., Duggan, K., Mur, L. A. J., Maillard, J.-Y., Brancale, A. & Hoffmann, K. F., 01 Dec 2024, In: MicrobiologyOpen. 13, 6, e011.

Research output: Contribution to journal › Comment/Debate

Open Access

File

1 Downloads (Pure)

Gut microbiota and immune profiling of microbiota-humanised versus wildtype mouse models of hepatointestinal schistosomiasis

Stark, K. A., Rinaldi, G., Costain, A., Clare, S., Tolley, C., Almeida, A., McCarthy, C., Harcourt, K., Brandt, C., Lawley, T. D., Berriman, M., MacDonald, A. S., Forde-Thomas, J. E., Hulme, B. J., Hoffmann, K. F., Cantacessi, C. & Cortés, A., 01 Dec 2024, In: Animal Microbiome. 6, 1, 19 p., 36.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

3 Downloads (Pure)

Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity

Rawat, M., Padalino, G., Yeo, T., Brancale, A., Fidock, D. A., Hoffmann, K. F. & Lee, M. C. S., 24 Apr 2024, bioRxiv.

Research output: Working paper › Preprint

Open Access

File

6 Downloads (Pure)

2023

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes

Padalino, G., Celatka, C., Rienhoff Jr., H. Y., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I., Brancale, A., Grunau, C. & Hoffmann, K., 30 Mar 2023, In: Wellcome Open Research. 8, 146, 29 p., 146.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

54 Downloads (Pure)

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

Chakroborty, A., Pritchard, D., Bouillon, M. E., Cervi, A., Kraehenbuehl, R., Wild, C., Fenn, C., Holdsworth, P. A., Capner, C., Padalino, G., Forde-Thomas, J., Payne, J., Smith, B. G., Fisher, M., Lahmann, M., Baird, M. S. & Hoffmann, K., 03 Jul 2023, In: Pharmaceutics. 15, 7, 15 p., 1869.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

52 Downloads (Pure)

Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

Caldwell, N., Afshar, R., Baragaña, B., Bustinduy, A. L., Caffrey, C. R., Collins, J. J., Fusco, D., Garba, A., Gardner, M., Gomes, M., Hoffmann, K. F., Hsieh, M., Lo, N. C., McNamara, C. W., Nono, J. K., Padalino, G., Read, K. D., Roestenberg, M., Spangenberg, T. & Specht, S. & 1 others, Gilbert, I. H., 12 May 2023, In: ACS Infectious Diseases. 9, 5, p. 1046-1055 10 p.

Research output: Contribution to journal › Review Article › peer-review

Open Access

File

19 Citations (Scopus)

75 Downloads (Pure)

Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis

Houlder, E. L., Costain, A. H., Nambuya, I., Brown, S. L., Koopman, J. P. R., Langenberg, M. C. C., Janse, J. J., Hoogerwerf, M. A., Ridley, A. J. L., Forde-Thomas, J. E., Colombo, S. A. P., Winkel, B. M. F., Galdon, A. A., Hoffmann, K. F., Cook, P. C., Roestenberg, M., Mpairwe, H. & MacDonald, A. S., 01 Dec 2023, In: Nature Communications. 14, 1, 12 p., 1863.

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

133 Downloads (Pure)

Small Molecule Ligands of the BET-like Bromodomain, SmBRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development

Schiedel, M., McArdle, D. J. B., Padalino, G., Chan, A. K. N., Forde-Thomas, J., McDonough, M., Whiteland, H., Beckmann, M., Cookson, R., Hoffmann, K. F. & Conway, S. J., 14 Dec 2023, In: Journal of Medicinal Chemistry. 66, 23, p. 15801-15822 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility

White, R., Sotillo, J., Ancarola, M. E., Borup, A., Boysen, A. T., Brindley, P. J., Buzás, E. I., Cavallero, S., Chaiyadet, S., Chalmers, I. W., Cucher, M. A., Dagenais, M., Davis, C. N., Devaney, E., Duque-Correa, M. A., Eichenberger, R. M., Fontenla, S., Gasan, T. A., Hokke, C. H. & Kosanovic, M. & 22 others, Kuipers, M. E., Laha, T., Loukas, A., Maizels, R. M., Marcilla, A., Mazanec, H., Morphew, R. M., Neophytou, K., Nguyen, L. T., Nolte-'t Hoen, E., Povelones, M., Robinson, M. W., Rojas, A., Schabussova, I., Smits, H. H., Sungpradit, S., Tritten, L., Whitehead, B., Zakeri, A., Nejsum, P., Buck, A. H. & Hoffmann, K. F., 05 Jan 2023, In: Journal of Extracellular Vesicles. 12, 1, 16 p., 12298.

Research output: Contribution to journal › Article › peer-review

Open Access

File

31 Citations (Scopus)

97 Downloads (Pure)

2022

Flukicidal effects of abietane diterpenoid derived analogues against the food borne pathogen Fasciola hepatica.

Chakroborty, A., Pritchard, D., Bouillon, M. E., Cervi, A., Cookson, A., Wild, C., Fenn, C., Payne, J., Holdsworth, P., Capner, C., O'Neill, J., Padalino, G., Forde-Thomas, J., Gupta, S., Smith, B. G., Fisher, M., Lahmann, M., Baird, M. S. & Hoffmann, K. F., 01 Sept 2022, In: Veterinary Parasitology. 309, 9 p., 109766.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

88 Downloads (Pure)

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

Hulme, B. J., Geyer, K. K., Forde-Thomas, J. E., Padalino, G., Phillips, D. W., Ittiprasert, W., Karinshak, S. E., Mann, V. H., Chalmers, I. W., Brindley, P. J., Hokke, C. H. & Hoffmann, K. F., 13 Jan 2022, In: PLoS Pathogens. 18, 1, 35 p., e1009828.

Research output: Contribution to journal › Article › peer-review

Open Access

File

20 Citations (Scopus)

126 Downloads (Pure)

2021

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation

Padalino, G., El-Sakkary, N., Liu, L. J., Liu, C., Harte, D. S. G., Barnes, R. E., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A. T., Caffrey, C. R., Chalmers, I., Brancale, A. & Hoffmann, K. F., 15 Dec 2021, In: European Journal of Medicinal Chemistry. 226, 19 p., 113823.

Research output: Contribution to journal › Article › peer-review

Open Access

File

12 Citations (Scopus)

164 Downloads (Pure)

Daily rhythms in gene expression of the human parasite Schistosoma mansoni

Rawlinson, K. A., Reid, A. J., Lu, Z., Driguez, P., Wawer, A., Coghlan, A., Sankaranarayanan, G., Buddenborg, S. K., Soria, C. D., McCarthy, C., Holroyd, N., Sanders, M., Hoffmann, K. F., Wilcockson, D., Rinaldi, G. & Berriman, M., 02 Dec 2021, In: BMC Biology. 19, 1, p. 255 255.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni

Craven, H., Bonsignore, R., Lenis, V., Santi, N., Berrar, D., Swain, M., Whiteland, H., Casini, A. & Hoffmann, K., 18 Feb 2021, In: PLoS Neglected Tropical Diseases. 15, 2, 24 p., e0008770.

Research output: Contribution to journal › Article › peer-review

Open Access

File

6 Citations (Scopus)

145 Downloads (Pure)

Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout Schistosoma mansoni Infection

Webb, L. M., Phythian-Adams, A. T., Costain, A. H., Brown, S. L., Lundie, R. J., Forde-Thomas, J., Cook, P. C., Jackson-Jones, L. H., Marley, A. K., Smits, H. H., Hoffmann, K. F., Tait Wojno, E. D. & MacDonald, A. S., 31 Aug 2021, In: ImmunoHorizons. 5, 8, p. 721-732 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

Gasan, T. A., Kuipers, M. E., Roberts, G. H., Padalino, G., Forde-Thomas, J. E., Wilson, S., Wawrzyniak, J., Tukahebwa, E. M., Hoffmann, K. F. & Chalmers, I. W., 18 Nov 2021, In: PLoS Neglected Tropical Diseases. 15, 11, e0009981.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function

Perally, S., Geyer, K. K., Farani, P. S. G., Chalmers, I. W., Fernandez-Fuentes, N., Maskell, D. R., Hulme, B. J., Forde-Thomas, J., Phillips, D., Farias, L. P., Collins, J. J. & Hoffmann, K. F., 01 Mar 2021, In: International Journal for Parasitology. 51, 4, p. 251-261 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

7 Citations (Scopus)

105 Downloads (Pure)

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni

Partridge, F. A., Bataille, C. J. R., Forman, R., Marriott, A. E., Forde-Thomas, J., Häberli, C., Dinsdale, R. L., O'Sullivan, J. D. B., Willis, N. J., Wynne, G. M., Whiteland, H., Archer, J., Steven, A., Keiser, J., Turner, J. D., Hoffmann, K. F., Taylor, M. J., Else, K. J., Russell, A. J. & Sattelle, D. B., 14 May 2021, In: ACS Infectious Diseases. 7, 5, p. 1260-1274 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

11 Citations (Scopus)

468 Downloads (Pure)

2020

DC‐SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte‐derived dendritic cells

Kuipers, M. E., Nolte-‘t Hoen, E. N. M., van der Ham, A. J., Ozir-Fazalalikhan, A., Nguyen, D. L., de Korne, C. M., Koning, R. I., Tomes, J. J., Hoffmann, K. F., Smits, H. H. & Hokke, C. H., 01 Sept 2020, In: Journal of Extracellular Vesicles. 9, 1, 19 p., 1753420.

Research output: Contribution to journal › Article › peer-review

Open Access

File

54 Citations (Scopus)

91 Downloads (Pure)

Helminth extracellular vesicles: Great balls of wonder

Hoffmann, K. F., Hokke, C. H., Loukas, A. & Buck, A. H., 05 Aug 2020, In: International Journal for Parasitology. 50, 9, p. 621-622 2 p.

Research output: Contribution to journal › Editorial

7 Citations (Scopus)

Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities

Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K. F., 13 Nov 2020, In: Wellcome Open Research. 5, 37 p., 169.

Research output: Contribution to journal › Article › peer-review

Open Access

File

6 Citations (Scopus)

75 Downloads (Pure)

Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni

Wang, J., Paz, C., Padalino, G., Coghlan, A., Lu, Z., Gradinaru, I., Collins, J. N. R., Berriman, M., Hoffmann, K. F. & Collins, J. J., 25 Sept 2020, In: Science (New York, N.Y.). 369, 6511, p. 1649-1653 5 p., eabb7699.

Research output: Contribution to journal › Article › peer-review

Open Access

File

58 Citations (Scopus)

230 Downloads (Pure)

Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal

Whiteland, H., Crusco, A., Bloemberg, L. W., Tibble-Howlings, J., Forde-Thomas, J., Coghlan, A., Murphy, P. J. & Hoffmann, K. F., 19 Oct 2020, In: PLoS Neglected Tropical Diseases. 14, 10, 22 p., e0008630.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

234 Downloads (Pure)

The synthesis and glycosidase inhibitory activity of analogues of tiruchanduramine

Ashworth, Z. J. R., Bartholomew, B., Evans, D. M., Forde-Thomas, J., Hoffmann, K. F., Murdoch, R., Nash, R. J., Sharp, H., Whiteland, H. & Murphy, P. J., 19 Mar 2020, In: Heterocycles. 100, 4, p. 609-621 13 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

2019

Antischistosomal Properties of Sclareol and Its Heck-Coupled Derivatives: Design, Synthesis, Biological Evaluation and Untargeted Metabolomics

Crusco, A., Whiteland, H., Baptista, R., Forde-Thomas, J. E., Beckmann, M., Mur, L. A. J., Nash, R. J., Westwell, A. D. & Hoffmann, K. F., 12 Jul 2019, In: ACS Infectious Diseases. 5, 7, p. 1188-1199 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

28 Citations (Scopus)

519 Downloads (Pure)

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

Wannaporn, I., Mann, V., Karinshak, S., Coghlan, A., Rinaldi, G., Sankaranarayanan, G., Chaidee, A., Tanno, T., Kumkhaek, C., Prangtaworn, P., Mentink-Kane, M. M., Cochran, C. J., Driguez, P., Holroyd, N., Tracey, A., Rodpai, R., Everts, B., Hokke, C. H., Hoffmann, K. & Berriman, M. & 1 others, Brindley, P. J., 15 Jan 2019, In: eLife. 8, N/A, 27 p., e41337.

Research output: Contribution to journal › Article › peer-review

Open Access

File

78 Citations (Scopus)

216 Downloads (Pure)

Schistosoma mansoni venom allergen-like proteins: Phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

Farias, L. P., Chalmers, I. W., Perally, S., Rofatto, H. K., Jackson, C. J., Brown, M., Khouri, M. I., Barbosa, M. M. F., Hensbergen, P. J., Hokke, C. H., Leite, L. C. C. & Hoffmann, K. F., 01 Jul 2019, In: International Journal for Parasitology. 49, 8, p. 593-599 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

175 Downloads (Pure)

The anti-mycobacterial activity of a diterpenoid-like molecule operates through nitrogen and amino acid starvation

Crusco, A., Alves Baptista, R., Bhowmick, S., Beckmann, M., Mur, L., Westwell, A. D. & Hoffmann, K., 25 Jun 2019, In: Frontiers in Microbiology. 10, JUN, 1444.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

209 Downloads (Pure)

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Nov 2019, In: PLoS Neglected Tropical Diseases. 13, 11, 24 p., e0007693.

Research output: Contribution to journal › Article › peer-review

Open Access

File

21 Citations (Scopus)

234 Downloads (Pure)

2018

An Abeis procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni

Whiteland, H., Chakroborty, A., Forde-Thomas, J., Crusco, A., Cookson, A., Hollinshead, J., Fenn, C., Bartholomew, B., Holdsworth, P. A., Fisher, M., Nash, R. J. & Hoffmann, K., 01 Dec 2018, In: International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 465-474 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

27 Citations (Scopus)

169 Downloads (Pure)

Antibody Responses to Schistosoma mansoni Schistosomula Antigens

Egesa, M., Lubyayi, L., Jones, F. M., van Diepen, A., Chalmers, I., Tukahebwa, E. M., Bagaya, B. S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Elliot, A. M., Yazdanbakhsh, M., Wilson, S. & Cose, S., 28 Nov 2018, In: Parasite Immunology. 40, 12, e12591.

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

165 Downloads (Pure)

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., 31 Dec 2018, In: International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 559-570 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

27 Citations (Scopus)

188 Downloads (Pure)

Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues

Crusco, A., Bordoni, C., Chakroborty, A., Whatley, K. C. L., Whiteland, H., Westwell, A. D. & Hoffmann, K., 25 May 2018, In: European Journal of Medicinal Chemistry. 152, N/A, p. 87-100 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

31 Citations (Scopus)

192 Downloads (Pure)

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni

Roquis, D., Taudt, A., Geyer, K., Padalino, G., Hoffmann, K., Holroyd, N., Berriman, M., Allaga, B., Chaparro, C., Grunau, C. & de Carvalho Augusto, R., 21 May 2018, In: PLoS Pathogens. 14, 5, 26 p., e1007066.

Research output: Contribution to journal › Article › peer-review

Open Access

File

37 Citations (Scopus)

179 Downloads (Pure)

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni

Geyer, K., Munshi, S. E., Whiteland, H., Fernandez-Fuentes, N., Phillips, D. & Hoffmann, K., 28 Jun 2018, In: PLoS Pathogens. 14, 6, e1007107.

Research output: Contribution to journal › Article › peer-review

Open Access

File

12 Citations (Scopus)

212 Downloads (Pure)

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J. M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M. & Beckham, C. & 362 others, Bedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borràs, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M., Brigstock, D. R., Brisson, A., Broekman, M. L. D., Bromberg, J. F., Bryl-Górecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzás, E. I., Byrd, J. B., Camussi, G., Carter, D. R. F., Caruso, S., Chamley, L. W., Chang, Y. T., Chaudhuri, A. D., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A. W., Coyle, B., Crescitelli, R., Criado, M. F., D’Souza-Schorey, C., Das, S., de Candia, P., De Santana, E. F., De Wever, O., del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A. P., Duarte, F. V., Duncan, H. M., Eichenberger, R. M., Ekström, K., EL Andaloussi, S., Elie-Caille, C., Erdbrügger, U., Falcón-Pérez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Försönits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gámez-Valero, A., Gardiner, C., Gärtner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C. I., Görgens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A. G. E., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S. I., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanović, M. M., Kovács, Á. F., Krämer-Albers, E. M., Krasemann, S., Krause, M., Kurochkin, I. V., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lässer, C., Laurent, L. C., Lavieu, G., Lázaro-Ibáñez, E., Le Lay, S., Lee, M. S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T. S., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Linē, A., Linnemannstöns, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lörincz, Á. M., Lötvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L. N., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L. K., McVey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Möller, A., Møller Jørgensen, M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Nolte-’t Hoen, E. N. M., Noren Hooten, N., O’Driscoll, L., O’Grady, T., O’Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C. H., Pink, R. C., Pisetsky, D. S., Pogge von Strandmann, E., Polakovicova, I., Poon, I. K. H., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M. I., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M. A., Rughetti, A., Russell, A. E., Saá, P., Sahoo, S., Salas-Huenuleo, E., Sánchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schøyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P. R. M., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sódar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Tosar, J. P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W. M., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J. C., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Vasconcelos, M. H., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, É., Verweij, F. J., Vestad, B., Viñas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H. M., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yáñez-Mó, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Žėkas, V., Zhang, J. Y., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D. & Zuba-Surma, E. K., 01 Jan 2018, In: Journal of Extracellular Vesicles. 7, 1, 1535750.

Research output: Contribution to journal › Article › peer-review

Open Access

7965 Citations (Scopus)

Schistosoma mansoni schistosomula antigens induce Th1/Pro-inflammatory cytokine responses

Egesa, M., Lubyayi, L., Tukahebwa, E. M., Bagaya, B. S., Chalmers, I., Wilson, S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Yazdanbakhsh, M., Labuda, L. A. & Cose, S., 28 Nov 2018, In: Parasite Immunology. 40, 12, e12592.

Research output: Contribution to journal › Article › peer-review

Open Access

File

19 Citations (Scopus)

139 Downloads (Pure)

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities

Geyer, K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., Chaparro, C., Swain, M. & Hoffmann, K., 01 Aug 2018, In: International Journal for Parasitology: Drugs and Drug Resistance. 8, 2, p. 213-222 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

19 Citations (Scopus)

207 Downloads (Pure)

2017

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Cosseau, C., Wolkenhauer, O., Padalino, G., Geyer, K., Hoffmann, K. & Grunau, C., 01 Apr 2017, In: Trends in Parasitology. 33, 4, p. 285-294 10 p.

Research output: Contribution to journal › Review Article › peer-review

Open Access

File

27 Citations (Scopus)

217 Downloads (Pure)

Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense

Nur-e-Alam, M., Yousaf, M., Ahmed, S., Al-Sheddi, E. S., Shah, I., Fazakerley, D., Bari, A., Ghabbour, H. A., Threadgill, M. D., Whatley, K., Hoffmann, K. & Al-Rehaily, A. J., 23 Jun 2017, In: Journal of Natural Products. 80, 6, p. 1900-1908 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

16 Citations (Scopus)

271 Downloads (Pure)

Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Egesa, M., Hoffmann, K., Hokke, C. H., Yazdanbakhsh, M. & Cose, S., 01 Dec 2017, In: Trends in Parasitology. 33, 12, p. 918-921 4 p., 1671.

Research output: Contribution to journal › Article › peer-review

Open Access

File

15 Citations (Scopus)

272 Downloads (Pure)

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S. E., Grunau, C., Yoshino, T. P. & Hoffmann, K., 16 May 2017, In: PLoS Neglected Tropical Diseases. 11, 5, 29 p., e0005246.

Research output: Contribution to journal › Article › peer-review

Open Access

File

35 Citations (Scopus)

214 Downloads (Pure)

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Adema, C. M., Hillier, L. W., Jones, C. S., Loker, E. S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L. R., Arican-Goktas, H. D., Assis, J. G., Baba, E. H., Baron, O. L., Bayne, C. J., Bickham-Wright, U., Biggar, K. K., Blouin, M., Bonning, B. C. & Botka, C. & 97 others, Bridger, J. M., Buckley, K. M., Buddenborg, S. K., Lima Caldeira, R., Carleton, J., Carvalho, O. S., Castillo, M. G., Chalmers, I. W., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R. M., Cuesta-Astroz, Y., Cummins, S. F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S. G., Geusz, M., Geyer, K. K., Giraldo-Calderón, G. I., de Souza Gomes, M., Gordy, M. A., Gourbal, B., Grunau, C., Hanington, P. C., Hoffmann, K. F., Hughes, D., Humphries, J., Jackson, D. J., Jannotti-Passos, L. K., De Jesus Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J. M., Kohn, A. B., Lawson, D., Lawton, S. P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A. E., Lovato, T. L., Ludolf, F., Magrini, V., Mcmanus, D. P., Medina, M., Misra, M., Mitta, G., Mkoji, G. M., Montague, M. J., Montelongo, C., Moroz, L. L., Munoz-Torres, M. C., Niazi, U., Noble, L. R., Oliveira, F. S., Pais, F. S., Papenfuss, A. T., Peace, R., Pena, J. J., Pila, E. A., Quelais, T., Raney, B. J., Rast, J. P., Rollinson, D., Rosse, I. C., Rotgans, B., Routledge, E. J., Ryan, K. M., Scholte, L. L. S., Storey, K. B., Swain, M., Tennessen, J. A., Tomlinson, C., Trujillo, D. L., Volpi, E. V., Walker, A. J., Wang, T., Wannaporn, I., Warren, W. C., Wu, X.-J., Yoshino, T. P., Yusuf, M., Zhang, S.-M., Zhao, M. & Wilson, R. K., 16 May 2017, In: Nature Communications. 8, p. 15451 15451.

Research output: Contribution to journal › Article › peer-review

Open Access

File

200 Citations (Scopus)

171 Downloads (Pure)

2016

DISMISS: Detection of stranded methylation in MeDIP-Seq data

Niazi, U., Geyer, K. K., Vickers, M. J., Hoffmann, K. & Swain, M., 29 Jul 2016, In: BMC Bioinformatics. 17, 1, 295.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

157 Downloads (Pure)

DISMISS: MeDIP-seq: High-throughput sequencing

Niazi, U., Geyer, K., Vickers, M. (Developer), Hoffmann, K. & Swain, M., 02 Aug 2016

Research output: Non-textual form › Software

Open Access

File

2015

Drug-Induced Exposure of Schistosoma mansoni Antigens SmCD59a and SmKK7

Reimers, N., Homann, A., Höschler, B., Langhans, K., Wilson, R. A., Pierrot, C., Khalife, J., Grevelding, C. G., Chalmers, I. W., Yazdanbakhsh, M., Hoffmann, K. F., Hokke, C. H., Haas, H. & Schramm, G., 16 Mar 2015, In: PLoS Neglected Tropical Diseases. 9, 3, e0003593.

Research output: Contribution to journal › Article › peer-review

Open Access

File

26 Citations (Scopus)

174 Downloads (Pure)

Glycomic analysis of life stages of the human parasite Schistosoma mansoni reveals developmental expression profiles of functional and antigenic glycan motifs

Smit, C. H., van Diepen, A., Nguyen, D. L., Wuhrer, M., Hoffmann, K. F., Deelder, A. M. & Hokke, C. H., 01 Jul 2015, In: Molecular and Cellular Proteomics. 14, 7, p. 1750-1769 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

80 Citations (Scopus)

167 Downloads (Pure)

Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment

Chalmers, I. W., Fitzsimmons, C. M., Brown, M., Pierrot, C., Jones, F. M., Wawrzyniak, J. M., Fernandez-Fuentes, N., Tukahebwa, E. M., Dunne, D. W., Khalife, J. & Hoffmann, K. F., Jul 2015, In: PLoS Neglected Tropical Diseases. 9, 7, p. e0003920 e0003920.

Research output: Contribution to journal › Article › peer-review

Open Access

File

16 Citations (Scopus)

221 Downloads (Pure)

Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni

Nowacki, F. C., Swain, M. T., Klychnikov, O. I., Niazi, U., Ivens, A., Quintana, J. F., Hensbergen, P. J., Hokke, C. H., Buck, A. H. & Hoffmann, K. F., 05 Oct 2015, In: Journal of Extracellular Vesicles. 4, 1, 28665.

Research output: Contribution to journal › Article › peer-review

Open Access

File

138 Citations (Scopus)

170 Downloads (Pure)

Karl Hoffmann

Research output

Search results