Personal profile
Research interests
I am interested in analysing large biological data sets from a variety of organisms, including plants, animals, parasites and microbes. Some recent and current projects include the sequencing of the tsetse fly and biomphalaria genomes, snake venom transcriptome analyses, methylation in flatworms, microRNAs, whole genome comparisons (of sheep and schistosomes), metagenomics of limpet guts and cryoconite, red clover transcriptomics, and the identification of neuropeptide receptors and functions in arthropods.
My other interests include the development of infrastructure and new software methodolgy for the handling and analysis of large data sets in bioinformatics. This involves high performance computing, technologies for data integration and data mining, and the development of new algorithms to analyse high-throughput sequencing data sets.
Teaching
An introduction to Linux and Bioinformatics for PGM1520; Study and Communication Skills, BR12410; Molecular Laboratory Skills, BR12210; Research Methods, Dissertation, and a few lectures to other modules.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger
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SDG 3 Good Health and Well-being
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SDG 6 Clean Water and Sanitation
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SDG 14 Life Below Water
Fingerprint
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Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery
Davey, S. D., Forde-Thomas, J. E., Hulme, B. J., Lees, K., Costain, A. H., Evans, M., Rinaldi, G., Frame, L., Stojanovski, L., Simeons, F. R. C., Tavendale, A., MacLeod, A. K., Pichon, R., Lee, Y.-H., Polak, O., Chalmers, I. W., Dankwa, B., Odhiambo, B. K., Guimaraes, V. H. & Hegarty, M. & 8 others, , 14 Apr 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 15, 12 p., e2600197123.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A review of recent Cryptosporidium hominis and Cryptosporidium parvum gp60 subtypes
Oladele, D. B., Swain, M., Robinson, G., Clare, A. & Chalmers, R. M., 21 Jul 2025, In: Current Research in Parasitology and Vector-Borne Diseases. 8, 13 p., 100292.Research output: Contribution to journal › Review Article › peer-review
Open AccessFile5 Citations (Scopus)14 Downloads (Pure) -
Investigating within-host population diversity of Cryptosporidium parvum using BlooMine
Morris, A. V., Connor, T., Pachebat, J. & Swain, M., 20 Nov 2025, In: BMC Genomics. 26, 1, 14 p., 1067.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
The RNA cargo of Myxococcus outer membrane vesicles
Swain, M. T., Radford, E. J., Akanyeti, A. S., Hallwood, J. H. & Whitworth, D. E., 19 Feb 2024, In: Molecular Omics. 20, 2, p. 138-145 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)21 Downloads (Pure) -
Towards Ceramics Inspired Physiotherapy for Recovering Stroke Patients
Hajzer, S. P., Jones, A., Jones, D., Miles, H., Ellis, V., Villagra Povina, F., Sganga, M., Swain, M. & Bennett-Gillison, S., 14 Sept 2023, Computer Graphics and Visual Computing. EurographicsResearch output: Chapter in Book/Report/Conference proceeding › Conference Proceeding (ISBN)
Open Access -
An eco‐epidemiological modeling approach to investigate dilution effect in two different tick‐borne pathosystems
Occhibove, F., Kenobi, K., Swain, M. & Risley, C., 01 Apr 2022, In: Ecological Applications. 32, 3, 24 p., e2550.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)143 Downloads (Pure) -
Complimentary protein extraction methods increase the identification of the Park Grass Experiment metaproteome
Quinn, G. A., Abdelhameed, A., Banat, I. M., Berrar, D., Doerr, S. H., Dudley, E., Francis, L. W., Gazze, S. A., Hallin, I., Matthews, G. P., Swain, M. T., Whalley, W. R. & van Keulen, G., 31 May 2022, In: Applied Soil Ecology. 173, 5 p., 104388.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)92 Downloads (Pure) -
In silico characterisation of the complete Ly6 protein family in Fasciola gigantica supported through transcriptomics of the newly-excysted juveniles
Davey, S. D., Chalmers, I. W., Fernandez-Fuentes, N., Swain, M. T., Smith, D., Abbas Abidi, S. M., Saifullah, M. K., Raman, M., Ravikumar, G., McVeigh, P., Maule, A. G., Brophy, P. M. & Morphew, R. M., 17 Jan 2022, In: Molecular Omics. 18, 1, p. 45-56 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)105 Downloads (Pure) -
Interpreting alignment-free sequence comparison: What makes a score a good score?
Swain, M. T. & Vickers, M., 05 Sept 2022, In: NAR Genomics and Bioinformatics. 4, 3, 22 p., lqac062.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)27 Downloads (Pure) -
Evidence of Immune Modulators in the Secretome of the Equine Tapeworm Anoplocephala perfoliata
Wititkornkul, B., Hulme, B. J., Tomes, J. J., Allen, N. R., Davis, C. N., Davey, S. D., Cookson, A. R., Phillips, H. C., Hegarty, M. J., Swain, M. T., Brophy, P. M., Wonfor, R. E. & Morphew, R. M., 20 Jul 2021, In: Pathogens. 10, 7, 30 p., e912.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)230 Downloads (Pure) -
Genotyping and Whole-Genome Resequencing of Welsh Sheep Breeds Reveal Candidate Genes and Variants for Adaptation to Local Environment and Socioeconomic Traits
Sweet-Jones, J., Lenis, V. P., Yurchenko, A. A., Yudin, N. S., Swain, M. & Larkin, D. M., 18 Jun 2021, In: Frontiers in Genetics. 12, 13 p., 612492.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)119 Downloads (Pure)
Datasets
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Interpreting alignment free sequence comparison: what makes a score a good score
Swain, M., Prifysgol Aberystwyth | Aberystwyth University, 01 Feb 2022
DOI: 10.20391/3e9573af-363b-4ff7-9f27-72eb84440b68
Dataset
File -
Microbial genome sequences and taxonomic information based on the Genometa 2012 data set
Swain, M., Prifysgol Aberystwyth | Aberystwyth University, 18 Jul 2019
DOI: 10.20391/e6974906-f30f-4976-90fb-ea1679eedef0
Dataset
File -
Evolutionary genomics of anthroponosis in Cryptosporidium
Swain, M., Pachebat, J. A., Robinson, G. & Chalmers, R. M., Prifysgol Aberystwyth | Aberystwyth University, 26 Sept 2018
DOI: 10.20391/8f137d06-4827-4829-ae7b-fac592d57942
Dataset
File
Projects
- 7 Finished
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Genomic analysis of Toxoplasma gondii direct from clinical samples using selective genome enrichment.
Swain, M. (Project Lead) & Nalepa-Grajcar, J. (Researcher Co‑Lead)
09 Oct 2017 → 08 Oct 2020
Project: Internally funded research
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ISPG-National Phenomics Centre see project 12520
Doonan, J. (Project Lead), Camargo-Rodriguez, A. (Researcher Co‑Lead), Clare, A. (Researcher Co‑Lead), Draper, J. (Researcher Co‑Lead), Howarth, C. (Researcher Co‑Lead), Powell, W. (Researcher Co‑Lead), Swain, M. (Researcher Co‑Lead) & Zwiggelaar, R. (Researcher Co‑Lead)
Biotechnology and Biological Sciences Research Council
01 Apr 2017 → 31 Mar 2019
Project: Externally funded research
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Improving Cryptosporidium diagnostics and understanding of transmission by mining crypsodium genomes
Swain, M. (Project Lead) & Morris, A. (Researcher Co‑Lead)
01 May 2016 → 30 Apr 2019
Project: Internally funded research
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Unravelling the ecdysis cascade in crustaceans: Can we unify neuropeptide and receptor identities and functions in arthropods?
Wilcockson, D. (Project Lead) & Swain, M. (Researcher Co‑Lead)
Biotechnology and Biological Sciences Research Council
01 Nov 2014 → 31 Oct 2017
Project: Externally funded research
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Flatworm DNA methylation: deciphering the mark and characterising the machinery
Hoffmann, K. (Project Lead) & Swain, M. (Researcher Co‑Lead)
Biotechnology and Biological Sciences Research Council
15 Apr 2013 → 14 Apr 2016
Project: Externally funded research
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RSB : Rumen Systems Biology
Kingston-Smith, A. (Project Lead), Swain, M. (Researcher Co‑Lead), Mur, L. (Researcher Co‑Lead), Creevey, C. (Researcher Co‑Lead), Allison, G. (Researcher Co‑Lead), Scollan, N. (Researcher Co‑Lead), Pachebat, J. (Researcher Co‑Lead), Newbold, J. (Researcher Co‑Lead), Morphew, R. (Researcher Co‑Lead), Griffith, G. (Researcher Co‑Lead) & Huws, S. (Researcher Co‑Lead)
Biotechnology and Biological Sciences Research Council
01 Apr 2012 → 31 Mar 2017
Project: Externally funded research
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Bioinformatics and genomic and phenomic platform development
Armstead, I. (Project Lead), Swain, M. (Researcher Co‑Lead), Doonan, J. (Researcher Co‑Lead), Boyle, R. (Researcher Co‑Lead), Hegarty, M. (Researcher Co‑Lead), Thomas, I. (Researcher Co‑Lead), Huang, L. (Researcher Co‑Lead), Fernandez Fuentes, N. (Researcher Co‑Lead), Neal, M. (Researcher Co‑Lead) & Gay, A. (Researcher Co‑Lead)
01 Apr 2012 → 31 Mar 2017
Project: Externally funded research
Activities
- 1 Visiting an external academic institution
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Queen's University Belfast
Creevey, C. (Visiting researcher) & Swain, M. (Visiting researcher)
2020 → …Activity: Visiting an external institution › Visiting an external academic institution