Research output per year
Research output per year
- 1 - 50 out of 82 results
Search results
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2025
Detoxome Capacity of the Adult Rumen Fluke Calicophoron daubneyi Extends into Its Secreted Extracellular Vesicles
Allen, N., Huson, K. M., Prchal, L., Robinson, M. W., Brophy, P. & Morphew, R. M., 19 Jan 2025, In: Journal of Proteome Research. 24, 2, p. 624-638 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2024
A dominance of Mu class glutathione transferases within the equine tapeworm Anoplocephala perfoliata
Northcote, H. M., Wititkornkul, B., Cutress, D., Allen, N., Brophy, P., Wonfor, R. & Morphew, R. M., 11 Mar 2024, In: Parasitology. 151, 3, p. 282-294 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Assessing periparturient ewe characteristics and nemabiome composition to guide targeted selective treatment for sustainable gastrointestinal nematodes control in sheep
Williams, E. G., Williams, H. W., Brophy, P. M., Evans, S. R., McCalman, H. & Jones, R. A., 01 Jun 2024, In: Animal. 18, 6, 101156.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of factors associated with Fasciola hepatica infection risk areas on pastures via an environmental DNA survey of Galba truncatula distribution using droplet digital and quantitative real-time PCR assays
Jones, R. A., Davis, C. N., Nalepa‐Grajcar, J., Woodruff, H., Williams, H. W., Brophy, P. M. & Jones, E., 06 Feb 2024, In: Environmental DNA. 6, 1, 12 p., e371.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)179 Downloads (Pure) -
2023
Discovery of long non-coding RNAs in the liver fluke, Fasciola hepatica
McVeigh, P., McCammick, E., Robb, E., Brophy, P., Morphew, R. M., Marks, N. J. & Maule, A. G., 28 Sept 2023, In: PLoS Neglected Tropical Diseases. 17, 9, e0011663.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)9 Downloads (Pure) -
2022
Associations between Gastrointestinal Nematode Infection Burden and Lying Behaviour as Measured by Accelerometers in Periparturient Ewes
Williams, E., Davis, C., Williams, M., Jones, D., Cutress, D., Williams, H., Brophy, P., Rose, M., Stuart, R. & Jones, R., 13 Sept 2022, In: Animals. 12, 18, 2393.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Fasciola hepatica Cathepsin L Zymogens: Immuno-Proteomic Evidence for Highly Immunogenic Zymogen-Specific Conformational Epitopes to Support Diagnostics Development
Collett, C., Phillips, H., Fisher, M., Smith, S., Fenn, C., Goodwin, P., Morphew, R. & Brophy, P., 05 Aug 2022, In: Journal of Proteome Research. 21, 8, p. 1997-2010 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)104 Downloads (Pure) -
In silico characterisation of the complete Ly6 protein family in Fasciola gigantica supported through transcriptomics of the newly-excysted juveniles
Davey, S. D., Chalmers, I. W., Fernandez-Fuentes, N., Swain, M. T., Smith, D., Abbas Abidi, S. M., Saifullah, M. K., Raman, M., Ravikumar, G., McVeigh, P., Maule, A. G., Brophy, P. M. & Morphew, R. M., 17 Jan 2022, In: Molecular Omics. 18, 1, p. 45-56 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)77 Downloads (Pure) -
2021
Evaluation of two Fasciola hepatica faecal egg counting protocols in sheep and cattle
Reigate, C., Williams, H. W., Denwood, M., Morphew, R., Thomas, E. & Brophy, P., 01 Jun 2021, In: Veterinary Parasitology. 294, 6 p., 109435.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)279 Downloads (Pure) -
Evidence of Immune Modulators in the Secretome of the Equine Tapeworm Anoplocephala perfoliata
Wititkornkul, B., Hulme, B. J., Tomes, J. J., Allen, N. R., Davis, C. N., Davey, S. D., Cookson, A. R., Phillips, H. C., Hegarty, M. J., Swain, M. T., Brophy, P. M., Wonfor, R. E. & Morphew, R. M., 20 Jul 2021, In: Pathogens. 10, 7, 30 p., e912.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)163 Downloads (Pure) -
Gastrointestinal nematode control practices in ewes: Identification of factors associated with application of control methods known to influence anthelmintic resistance development
Williams, E., Brophy, P., Williams, H. W., Davies, N. & Jones, R., 01 Apr 2021, In: Veterinary Parasitology: Regional Studies and Reports. 24, 100562.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)49 Downloads (Pure) -
In vitro screening as an anthelmintic discovery pipeline for Calicophoron daubneyi: Nutritive media and rumen environment-based approaches
Huson, K. M., Morphew, R., Winters, A., Cookson, A., Hauck, B. & Brophy, P., 01 Apr 2021, In: Parasitology Research. 120, 4, p. 1351-1362 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)124 Downloads (Pure) -
Modulation of Rumen Microbes Through Extracellular Vesicle Released by the Rumen Fluke Calicophoron daubneyi
Allen, N., Taylor-Mew, A. R., Wilkinson, T., Huws, S., Phillips, H., Morphew, R. & Brophy, P., 20 Apr 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 12 p., 661830.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)81 Downloads (Pure) -
Temporal dynamics of trematode intermediate snail host environmental DNA in small water body habitats
Jones, R. A., Davis, C. N., Jones, D. L., Tyson, F., Davies, E., Cutress, D., Brophy, P. M., Rose, M. T., Williams, M. & Williams, H. W., 01 Oct 2021, In: Parasitology. 148, 12, p. 1490-1496 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)69 Downloads (Pure) -
The soluble glutathione transferase superfamily: Role of Mu class in triclabendazole sulphoxide challenge in Fasciola hepatica
Stuart, R., Zwaanswijk, S., MacKintosh, N., Wititkornkul, B., Brophy, P. & Morphew, R., Mar 2021, In: Parasitology Research. 120, 3, p. 979–991 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)118 Downloads (Pure) -
2020
Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica
Davis, C., Winters, A., Milic, I., Devitt, A., Cookson, A., Brophy, P. & Morphew, R., 10 Aug 2020, In: Scientific Reports. 10, 1, 11 p., 13445.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)153 Downloads (Pure) -
Novel Equine Faecal Egg Diagnostics: Validation of the FECPAKG2
Tyson, F., Dalesman, S., Brophy, P. & Morphew, R., 23 Jul 2020, In: Animals. 10, 8, 10 p., 1254.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)113 Downloads (Pure) -
Pilot Evaluation of Two Fasciola hepatica Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics
Collett, C., Morphew, R., Timson, D., Phillips, H. & Brophy, P., 30 Jul 2020, In: Molecules. 25, 15, 14 p., 3477.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)114 Downloads (Pure) -
Rapid detection of Galba truncatula in water sources on pasture-land using loop-mediated isothermal amplification for control of trematode infections
Davis, C., Tyson, F., Cutress, D., Davies, E., Jones, D., Brophy, P., Prescott, A., Rose, M., Williams, M., Williams, H. & Jones, R., 30 Sept 2020, In: Parasites & Vectors. 13, 1, 11 p., 496.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)99 Downloads (Pure) -
RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development
McCosker, P., Hussain, W., McVeigh, P., McCammick, E., Clarke, N., McKay, F., Robb, E., Brophy, P., Timson, D., Mousley, A., Marks, N. & Maule, A., 01 Dec 2020, In: International Journal for Parasitology: Drugs and Drug Resistance. 14, p. 46-55 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)168 Downloads (Pure) -
2019
Smell of Infection: a novel, non-invasive method for detection of fish excretory- secretory proteins
Pawluk, R., Stuart, R., Garcia de Leaniz, C., Cable, J., Morphew, R., Brophy, P. & Consuegra, S., 01 Mar 2019, In: Journal of Proteome Research. 18, 3, p. 1371-1379 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)108 Downloads (Pure) -
The importance of extracellular vesicle purification for downstream analysis: A comparison of differential centrifugation and size exclusion chromatography for helminth pathogens
Davis, C., Phillips, H., Tomes, J., Swain, M., Wilkinson, T., Brophy, P. & Morphew, R., 27 Feb 2019, In: PLoS Neglected Tropical Diseases. 13, 2, 26 p., e0007191.Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Citations (Scopus)197 Downloads (Pure) -
X-ray structure of Fasciola hepatica Sigma class glutathione transferase 1 reveals a disulfide bond to support stability in gastro-intestinal environment
Line, K., Isupov, M. N., LaCourse, E. J., Cutress, D., Morphew, R., Brophy, P. & Littlechild, J. A., 01 Dec 2019, In: Scientific Reports. 9, 1, 902.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)181 Downloads (Pure) -
2018
Detection of Galba truncatula, Fasciola hepatica and Calicophoron daubneyi environmental DNA within water sources on pasture land, a future tool for fluke control?
Jones, R., Brophy, P., Davis, C., Davies, T., Emberson, H., Rees Stevens, P. & Williams, H., 08 Jun 2018, In: Parasites & Vectors. 11, N/A, 9 p., 342.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)250 Downloads (Pure) -
Inducible glutathione S-transferase (IrGST1) from the tick Ixodes ricinus is a haem-binding protein
Perner, J., Kotál, J., Hatalová , T., Urbanová , V., Bartošová-Sojková, P., Brophy, P. & Kopáček, P., 01 Apr 2018, In: Insect Biochemistry and Molecular Biology. 95, p. 44-54 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)269 Downloads (Pure) -
Polyomic tools for an emerging livestock parasite, the rumen fluke Calicophoron daubneyi; identifying shifts in rumen functionality
Huson, K. M., Morphew, R., Allen, N., Hegarty, M., Worgan, H., Girdwood, S., Jones, E. L., Phillips, H., Vickers, M., Swain, M., Smith, D., Kingston-Smith, A. & Brophy, P., 04 Dec 2018, In: Parasites & Vectors. 11, 1, 22 p., 617.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)383 Downloads (Pure) -
Purification of native Sigma Class Glutathione Transferase from Fasciola hepatica
Duncan, J., Cutress, D., Morphew, R. & Brophy, P., 01 Jun 2018, In: Molecular and Biochemical Parasitology. 222, p. 45-50 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)324 Downloads (Pure) -
2017
Prevalence of rumen fluke (Calicophoron daubneyi) in cattle herds, sheep flocks and in intermediate snail host, G. truncatula, on Welsh farms
Jones, R., Williams, H. & Brophy, P., 01 Apr 2017, In: Advances in Animal Biosciences. 8, 1, p. 66Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Downloads (Pure) -
Rumen fluke Calicophoron daubneyi on Welsh farms: Prevalence, risk factors, and observations on co-infection with Fasciola hepatica
Jones, R., Brophy, P., Mitchell, E. S. & Williams, H., 01 Feb 2017, In: Parasitology. 144, 2, p. 237-247 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)279 Downloads (Pure) -
The prevalence and development of digenean parasites within their intermediate snail host, Galba truncatula, in a geographic area where the presence of Calicophoron daubneyi has recently been confirmed
Jones, R., Williams, H., Dalesman, S., Sinmidele, A., Thomas, R. & Brophy, P., 15 Jun 2017, In: Veterinary Parasitology. 240, p. 68-74 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)206 Downloads (Pure) -
2016
Calmodulin disruption impacts growth and motility in juvenile liver fluke
McCammick, E., McVeigh, P., McCusker, P., Timson, D., Morphew, R., Brophy, P., Marks, N., Mousley, A. & Maule, A., 27 Jan 2016, In: Parasites & Vectors. 9, N/A, 13 p., 46.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)170 Downloads (Pure) -
Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species
Morphew, R., Wilkinson, T., MacKintosh, N., Jahndel, V., Paterson, S., McVeigh, P., Abbas Abidi, S. M., Saifullah, K., Raman, M., Ravikumar , G., LaCourse, E. J., Maule, A. G. & Brophy, P., 02 Sept 2016, In: Journal of Proteome Research. 15, 9, p. 3308-3321 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)273 Downloads (Pure) -
2015
A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: Case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus
Hart, E., Brophy, P., Prescott, M., Bartley, D. J., Wolf, B. & Hamilton, J. V., 30 Jan 2015, In: Veterinary Parasitology. 207, 3-4, p. 266-275 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)70 Downloads (Pure) -
Confirmation of Galba truncatula as an intermediate host snail for Calicophoron daubneyi in Great Britain, with evidence of alternative snail species hosting Fasciola hepatica
Jones, R., Williams, H., Dalesman, S. & Brophy, P., 23 Dec 2015, In: Parasites & Vectors. 8, 1, 4 p., 656.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)203 Downloads (Pure) -
2014
In vitro biomarker discovery in the parasitic flatworm Fasciola hepatica for monitoring chemotherapeutic treatment
Morphew, R. M., MacKintosh, N. D., Hart, E. H., Prescott, M., LaCourse, E. J. & Brophy, P. M., Jun 2014, In: EuPA Open Proteomics. 3, p. 85-99 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)196 Downloads (Pure) -
RNAi dynamics in juvenile Fasciola spp. liver flukes reveals the persistence of gene silencing in vitro
McVeigh, P., McCammick, E., McCusker, P., Morphew, R. M., Mousley, A., Abidi, A., Saifullah, K. M., Muthusamy, R., Gopalakrishnan, R., Spithill, T. W., Dalton, J. P., Brophy, P. M., Marks, N. J. & Maule, A. G., 25 Sept 2014, In: PLoS Neglected Tropical Diseases. 8, 9, 13 p., e3185.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Citations (Scopus)139 Downloads (Pure) -
Time-dependent tegumental surface changes in juvenile Fasciola gigantica in response to triclabendazole treatment in goat
Ahammed Shareef, P. A., Brennan, G. P., McVeigh, P., Hannan Khan, M. A., Morphew, R. M., Mousley, A., Marks, N. J., Khalid Saifullah, M. K., Brophy, P. M., Maule, A. G. & Abidi, S. M. A., Aug 2014, In: Acta Tropica. 136, p. 108-117 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)78 Downloads (Pure) -
2013
Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes
Geyer, K. K., Chalmers, I. W., MacKintosh, N. D., Hirst, J. E., Geoghegan, R., Badets, M., Brophy, P. M., Brehm, K. & Hoffmann, K. F., 09 Jul 2013, In: BMC Genomics. 14, 1, 462.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)191 Downloads (Pure) -
Early hepatic and peritoneal changes and immune response in goats vaccinated with a recombinant glutathione transferase sigma class and challenged with Fasciola hepatica.
Zafra, R., Pérez-Écija, R. A., Buffoni, L., Pacheco, I. L., Martínez-Moreno, A., Lacourse , E. J., Perally, S., Brophy, P. M. & Pérez, J., 01 Jun 2013, In: Research in Veterinary Science. 94, 3, p. 602-609 8 p.Research output: Contribution to journal › Article › peer-review
29 Citations (Scopus) -
Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40
Morphew, R. M., Hamilton, C. M., Wright, H. A., Dowling, D. J., O'Neill, S. M. & Brophy, P. M., 31 Jan 2013, In: Veterinary Parasitology. 191, 3-4, p. 379–385 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)70 Downloads (Pure) -
2012
Anthelmintic metabolism in parasitic helminths: proteomic insights
Brophy, P. M., Mackintosh, N. & Morphew, R. M., Aug 2012, In: Parasitology. 139, 9, p. 1205-1217 13 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
Proteomic profiling and protein identification by MALDI-TOF mass spectrometry in unsequenced parasitic nematodes.
Millares, P., LaCourse, J., Perally, S., Ward , D., Prescott, M., Hodgkinson , J., Brophy, P. M. & Rees, H., 29 Mar 2012, In: PLoS ONE. 7, 3, e33590.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)145 Downloads (Pure) -
Proteomics and in silico approaches to extend understanding of the glutathione transferase superfamily of the tropical liver fluke Fasciola gigantica
Morphew, R. M., Eccleston, N., Wilkinson, T. J., McGarry, J., Perally, S., Prescott, M., Ward, D., Williams, D., Paterson, S., Raman, M., Ravikumar, G., Khalid Saifullah, M., Abbas Abidi, S. M., McVeigh, P., Maule, A. G., Brophy, P. M. & LaCourse, E. J., 07 Dec 2012, In: Journal of Proteome Research. 11, 12, p. 5876–5889 14 p.Research output: Contribution to journal › Article › peer-review
File33 Citations (Scopus)43 Downloads (Pure) -
The Sigma Class glutathione transferase from the liver fluke Fasciola hepatica
LaCourse, E. J., Perally, S., Morphew, R. M., Moxon, J. V., Prescott, M. C., Dowling, D. J., O'Neill, S. M., Kipar, A., Hetzel, U., Hoey, E., Zafra, R., Buffoni, L., Arévalo, J. P. & Brophy, P. M., 01 May 2012, In: PLoS Neglected Tropical Diseases. 6, 5, e1666.Research output: Contribution to journal › Article › peer-review
Open AccessFile67 Citations (Scopus)235 Downloads (Pure) -
The soluble proteome phenotypes of ivermectin resistant and ivermectin susceptible Haemonchus contortus females compared
Hart, E. H., Morphew, R. M., Bartley, D. J., Millares, P., Wolf, B. T., Brophy, P. M. & Hamilton, J. V., Nov 2012, In: Veterinary Parasitology. 190, 1-2, p. 104-113 10 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
2011
Towards delineating functions within the fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics
Morphew, R. M., Wright, H. A., LaCourse, E. J., Porter, J., Barrett, J., Woods, D. J. & Brophy, P. M., 04 Jan 2011, In: PLoS Neglected Tropical Diseases. 5, 1, e-937.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)177 Downloads (Pure) -
2010
Comparative Proteomic Analysis of Triclabendazole Response in the Liver Fluke Fasciola hepatica
Chemale, G., Perally, S., LaCourse, E. J., Prescott, M. C., Jones, L. M., Ward, D., Meany, M., Hoey, E., Brennan, G. P., Fairweather, I., Trudgett, A. & Brophy, P. M., 01 Oct 2010, In: Journal of Proteome Research. 9, 10, p. 4940-4951 12 p.Research output: Contribution to journal › Article › peer-review
File48 Citations (Scopus)1 Downloads (Pure) -
Early Hepatic Changes in Goats Immunized with Recombinant Glutathione S Transferase (Sigma Class) and Challenged with Fasciola hepatica
Mendes, R. E., Zafra, R., Martinez-Moreno, A., Brophy, P. & Pérez, J., 25 Nov 2010, In: Journal of Comparative Pathology. 143, 4, p. 350 1 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Immune responses directed at egg proteins during experimental infection with the liver fluke Fasciola hepatica
Moxon, J. V., Flynn, R., Golden, O., Hamilton, J. V., Mulcahy, G. & Brophy, P. M., 01 Feb 2010, In: Parasite Immunology. 32, 2, p. 111-124 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)34 Downloads (Pure) -
Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses
Dowling, D. J., Hamilton, C. M., Donnelly, S., La Course, J., Brophy, P. M., Dalton, J. & O'Neill, S. M., Feb 2010, In: Infection and Immunity. 78, 2, p. 793-801 9 p.Research output: Contribution to journal › Article › peer-review
116 Citations (Scopus)