Research output per year
Research output per year
- 47 results
Search results
-
2024
A dominance of Mu class glutathione transferases within the equine tapeworm Anoplocephala perfoliata
Northcote, H. M., Wititkornkul, B., Cutress, D., Allen, N., Brophy, P., Wonfor, R. & Morphew, R. M., 11 Mar 2024, In: Parasitology. 151, 3, p. 282-294 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Discovery of long non-coding RNAs in the liver fluke, Fasciola hepatica
McVeigh, P., McCammick, E., Robb, E., Brophy, P., Morphew, R. M., Marks, N. J. & Maule, A. G., 28 Sept 2023, In: PLoS Neglected Tropical Diseases. 17, 9, e0011663.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)4 Downloads (Pure) -
Extracellular Vesicles in Microbes, Pathogens, and Infectious Diseases
Chow, F. & Morphew, R. M., 26 Jun 2023, In: International Journal of Molecular Sciences. 24, 13, 2 p., 10686.Research output: Contribution to journal › Editorial
Open AccessFile26 Downloads (Pure) -
Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility
White, R., Sotillo, J., Ancarola, M. E., Borup, A., Boysen, A. T., Brindley, P. J., Buzás, E. I., Cavallero, S., Chaiyadet, S., Chalmers, I. W., Cucher, M. A., Dagenais, M., Davis, C. N., Devaney, E., Duque-Correa, M. A., Eichenberger, R. M., Fontenla, S., Gasan, T. A., Hokke, C. H. & Kosanovic, M. & 22 others, , 05 Jan 2023, In: Journal of Extracellular Vesicles. 12, 1, 16 p., 12298.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)91 Downloads (Pure) -
2022
Characterization of microtubule-associated protein tau isoforms and Alzheimer’s disease-like pathology in normal sheep (Ovis aries): Relevance to their potential as a model of Alzheimer’s disease
Davies, E. S., Morphew, R. M., Cutress, D., Morton, A. J. & McBride, S., 01 Nov 2022, In: Cellular and Molecular Life Sciences. 79, 11, 19 p., 560.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)104 Downloads (Pure) -
Excretory-secretory products from the brown stomach worm, Teladorsagia circumcincta, exert antimicrobial activity in in vitro growth assays
Rooney, J., Williams, T., Northcote, H. M., Frankl, F., Price, D., Nisbet, A., Morphew, R. & Cantacessi, C., 01 Dec 2022, In: Parasites & Vectors. 15, 1, 15 p., 354.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)76 Downloads (Pure) -
Fasciola hepatica Cathepsin L Zymogens: Immuno-Proteomic Evidence for Highly Immunogenic Zymogen-Specific Conformational Epitopes to Support Diagnostics Development
Collett, C., Phillips, H., Fisher, M., Smith, S., Fenn, C., Goodwin, P., Morphew, R. & Brophy, P., 05 Aug 2022, In: Journal of Proteome Research. 21, 8, p. 1997-2010 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)109 Downloads (Pure) -
In silico characterisation of the complete Ly6 protein family in Fasciola gigantica supported through transcriptomics of the newly-excysted juveniles
Davey, S. D., Chalmers, I. W., Fernandez-Fuentes, N., Swain, M. T., Smith, D., Abbas Abidi, S. M., Saifullah, M. K., Raman, M., Ravikumar, G., McVeigh, P., Maule, A. G., Brophy, P. M. & Morphew, R. M., 17 Jan 2022, In: Molecular Omics. 18, 1, p. 45-56 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)79 Downloads (Pure) -
Parasitic helminths and the host microbiome: A missing ‘extracellular vesicle-sized’ link?
Rooney, J., Northcote, H. M., Williams, T., Cortes, A., Cantacessi, C. & Morphew, R., 01 Sept 2022, In: Trends in Parasitology. 38, 9, p. 737-747 11 p.Research output: Contribution to journal › Comment/Debate › peer-review
Open AccessFile16 Citations (Scopus)161 Downloads (Pure) -
2021
Evaluation of two Fasciola hepatica faecal egg counting protocols in sheep and cattle
Reigate, C., Williams, H. W., Denwood, M., Morphew, R., Thomas, E. & Brophy, P., 01 Jun 2021, In: Veterinary Parasitology. 294, 6 p., 109435.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)291 Downloads (Pure) -
Evidence of Immune Modulators in the Secretome of the Equine Tapeworm Anoplocephala perfoliata
Wititkornkul, B., Hulme, B. J., Tomes, J. J., Allen, N. R., Davis, C. N., Davey, S. D., Cookson, A. R., Phillips, H. C., Hegarty, M. J., Swain, M. T., Brophy, P. M., Wonfor, R. E. & Morphew, R. M., 20 Jul 2021, In: Pathogens. 10, 7, 30 p., e912.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)165 Downloads (Pure) -
In vitro screening as an anthelmintic discovery pipeline for Calicophoron daubneyi: Nutritive media and rumen environment-based approaches
Huson, K. M., Morphew, R., Winters, A., Cookson, A., Hauck, B. & Brophy, P., 01 Apr 2021, In: Parasitology Research. 120, 4, p. 1351-1362 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)116 Downloads (Pure) -
Modulation of Rumen Microbes Through Extracellular Vesicle Released by the Rumen Fluke Calicophoron daubneyi
Allen, N., Taylor-Mew, A. R., Wilkinson, T., Huws, S., Phillips, H., Morphew, R. & Brophy, P., 20 Apr 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 12 p., 661830.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)92 Downloads (Pure) -
The soluble glutathione transferase superfamily: Role of Mu class in triclabendazole sulphoxide challenge in Fasciola hepatica
Stuart, R., Zwaanswijk, S., MacKintosh, N., Wititkornkul, B., Brophy, P. & Morphew, R., Mar 2021, In: Parasitology Research. 120, 3, p. 979–991 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)123 Downloads (Pure) -
2020
Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica
Davis, C., Winters, A., Milic, I., Devitt, A., Cookson, A., Brophy, P. & Morphew, R., 10 Aug 2020, In: Scientific Reports. 10, 1, 11 p., 13445.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)162 Downloads (Pure) -
Novel Equine Faecal Egg Diagnostics: Validation of the FECPAKG2
Tyson, F., Dalesman, S., Brophy, P. & Morphew, R., 23 Jul 2020, In: Animals. 10, 8, 10 p., 1254.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)129 Downloads (Pure) -
Pilot Evaluation of Two Fasciola hepatica Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics
Collett, C., Morphew, R., Timson, D., Phillips, H. & Brophy, P., 30 Jul 2020, In: Molecules. 25, 15, 14 p., 3477.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)130 Downloads (Pure) -
Predatory Organisms with Untapped Biosynthetic Potential: Descriptions of Novel Corallococcus Species C. aberystwythensis sp. nov., C. carmarthensis sp. nov., C. exercitus sp. nov., C. interemptor sp. nov., C. llansteffanensis sp. nov., C. praedator sp. nov., C. sicarius sp. nov., and C. terminator sp. nov
Livingstone, P. G., Ingleby, O., Girdwood, S., Cookson, A. R., Morphew, R. M. & Whitworth, D. E., 07 Jan 2020, In: Applied and Environmental Microbiology. 86, 2, 14 p., e01931-19.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)136 Downloads (Pure) -
2019
Smell of Infection: a novel, non-invasive method for detection of fish excretory- secretory proteins
Pawluk, R., Stuart, R., Garcia de Leaniz, C., Cable, J., Morphew, R., Brophy, P. & Consuegra, S., 01 Mar 2019, In: Journal of Proteome Research. 18, 3, p. 1371-1379 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)113 Downloads (Pure) -
The importance of extracellular vesicle purification for downstream analysis: A comparison of differential centrifugation and size exclusion chromatography for helminth pathogens
Davis, C., Phillips, H., Tomes, J., Swain, M., Wilkinson, T., Brophy, P. & Morphew, R., 27 Feb 2019, In: PLoS Neglected Tropical Diseases. 13, 2, 26 p., e0007191.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)195 Downloads (Pure) -
Using next-generation sequencing to determine diversity of horse intestinal worms: Identifying the equine ʼnemabiome'
Mitchell, C., O'Sullivan, C., Pinloche, E.J.-Y. R., Wilkinson, T., Morphew, R. & McEwan, N., Mar 2019, In: Journal of Equine Science. 30, 1, p. 1-5 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)238 Downloads (Pure) -
X-ray structure of Fasciola hepatica Sigma class glutathione transferase 1 reveals a disulfide bond to support stability in gastro-intestinal environment
Line, K., Isupov, M. N., LaCourse, E. J., Cutress, D., Morphew, R., Brophy, P. & Littlechild, J. A., 01 Dec 2019, In: Scientific Reports. 9, 1, 902.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)188 Downloads (Pure) -
2018
Genome Analysis, Metabolic Potential, and Predatory Capabilities of Herpetosiphon llansteffanense sp. nov.
Livingstone, P., Morphew, R., Cookson, A. & Whitworth, D., 15 Nov 2018, In: Applied and Environmental Microbiology. 84, 22, e01040-18.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)197 Downloads (Pure) -
Genome Sequencing and Pan-Genome Analysis of 23 Corallococcus spp. Strains Reveal Unexpected Diversity, With Particular Plasticity of Predatory Gene Sets
Livingstone, P., Morphew, R. & Whitworth, D., 19 Dec 2018, In: Frontiers in Microbiology. 9, 3187.Research output: Contribution to journal › Article › peer-review
Open AccessFile58 Citations (Scopus)224 Downloads (Pure) -
Polyomic tools for an emerging livestock parasite, the rumen fluke Calicophoron daubneyi; identifying shifts in rumen functionality
Huson, K. M., Morphew, R., Allen, N., Hegarty, M., Worgan, H., Girdwood, S., Jones, E. L., Phillips, H., Vickers, M., Swain, M., Smith, D., Kingston-Smith, A. & Brophy, P., 04 Dec 2018, In: Parasites & Vectors. 11, 1, 22 p., 617.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)378 Downloads (Pure) -
Purification of native Sigma Class Glutathione Transferase from Fasciola hepatica
Duncan, J., Cutress, D., Morphew, R. & Brophy, P., 01 Jun 2018, In: Molecular and Biochemical Parasitology. 222, p. 45-50 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)314 Downloads (Pure) -
2017
Myxobacteria are able to prey broadly upon clinically-relevant pathogens, exhibiting a prey range which cannot be explained by phylogeny
Livingstone, P., Morphew, R. & Whitworth, D., 22 Aug 2017, In: Frontiers in Microbiology. 8, 1593.Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Citations (Scopus)236 Downloads (Pure) -
Saprotrophic proteomes of biotypes of the witches’ broom pathogen Moniliophthora perniciosa
Pierre, S., Griffith, G., Morphew, R., Mur, L. & Scott, I., 01 Sept 2017, In: Fungal Biology. 121, 9, p. 743-753 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)371 Downloads (Pure) -
Worms at the Royal Welsh Show
Tyson, F., Allen, T., Pennington, C., Brophy, P., Thomas, E. & Morphew, R., 07 Oct 2017, In: Veterinary Record. 181, 14, p. 376-377Research output: Contribution to journal › Letter
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2016
Calmodulin disruption impacts growth and motility in juvenile liver fluke
McCammick, E., McVeigh, P., McCusker, P., Timson, D., Morphew, R., Brophy, P., Marks, N., Mousley, A. & Maule, A., 27 Jan 2016, In: Parasites & Vectors. 9, N/A, 13 p., 46.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)179 Downloads (Pure) -
Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species
Morphew, R., Wilkinson, T., MacKintosh, N., Jahndel, V., Paterson, S., McVeigh, P., Abbas Abidi, S. M., Saifullah, K., Raman, M., Ravikumar , G., LaCourse, E. J., Maule, A. G. & Brophy, P., 02 Sept 2016, In: Journal of Proteome Research. 15, 9, p. 3308-3321 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)280 Downloads (Pure) -
The effects of PPO activity on the proteome of ingested red clover and implications for improving the nutrition of grazing cattle
Hart, E., Onime, L. A., Davies, T., Morphew, R. & Kingston-Smith, A., 01 Jun 2016, In: Journal of Proteomics. 141, p. 67-76 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)271 Downloads (Pure) -
2015
Identification of the rumen fluke Calicophoron daubneyi infecting cattle in Wales
Huson, K. M., Brophy, P., Morphew, R. & MacKintosh, N., 01 Apr 2015, In: Advances in Animal Biosciences. 6, Special Issue 02, p. 183 1 p.Research output: Contribution to journal › Meeting Abstract
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2014
In vitro biomarker discovery in the parasitic flatworm Fasciola hepatica for monitoring chemotherapeutic treatment
Morphew, R. M., MacKintosh, N. D., Hart, E. H., Prescott, M., LaCourse, E. J. & Brophy, P. M., Jun 2014, In: EuPA Open Proteomics. 3, p. 85-99 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)208 Downloads (Pure) -
RNAi dynamics in juvenile Fasciola spp. liver flukes reveals the persistence of gene silencing in vitro
McVeigh, P., McCammick, E., McCusker, P., Morphew, R. M., Mousley, A., Abidi, A., Saifullah, K. M., Muthusamy, R., Gopalakrishnan, R., Spithill, T. W., Dalton, J. P., Brophy, P. M., Marks, N. J. & Maule, A. G., 25 Sept 2014, In: PLoS Neglected Tropical Diseases. 8, 9, 13 p., e3185.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Citations (Scopus)133 Downloads (Pure) -
Time-dependent tegumental surface changes in juvenile Fasciola gigantica in response to triclabendazole treatment in goat
Ahammed Shareef, P. A., Brennan, G. P., McVeigh, P., Hannan Khan, M. A., Morphew, R. M., Mousley, A., Marks, N. J., Khalid Saifullah, M. K., Brophy, P. M., Maule, A. G. & Abidi, S. M. A., Aug 2014, In: Acta Tropica. 136, p. 108-117 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)80 Downloads (Pure) -
2013
Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40
Morphew, R. M., Hamilton, C. M., Wright, H. A., Dowling, D. J., O'Neill, S. M. & Brophy, P. M., 31 Jan 2013, In: Veterinary Parasitology. 191, 3-4, p. 379–385 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)82 Downloads (Pure) -
2012
Anthelmintic metabolism in parasitic helminths: proteomic insights
Brophy, P. M., Mackintosh, N. & Morphew, R. M., Aug 2012, In: Parasitology. 139, 9, p. 1205-1217 13 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
Proteomics and in silico approaches to extend understanding of the glutathione transferase superfamily of the tropical liver fluke Fasciola gigantica
Morphew, R. M., Eccleston, N., Wilkinson, T. J., McGarry, J., Perally, S., Prescott, M., Ward, D., Williams, D., Paterson, S., Raman, M., Ravikumar, G., Khalid Saifullah, M., Abbas Abidi, S. M., McVeigh, P., Maule, A. G., Brophy, P. M. & LaCourse, E. J., 07 Dec 2012, In: Journal of Proteome Research. 11, 12, p. 5876–5889 14 p.Research output: Contribution to journal › Article › peer-review
File31 Citations (Scopus)40 Downloads (Pure) -
The Sigma Class glutathione transferase from the liver fluke Fasciola hepatica
LaCourse, E. J., Perally, S., Morphew, R. M., Moxon, J. V., Prescott, M. C., Dowling, D. J., O'Neill, S. M., Kipar, A., Hetzel, U., Hoey, E., Zafra, R., Buffoni, L., Arévalo, J. P. & Brophy, P. M., 01 May 2012, In: PLoS Neglected Tropical Diseases. 6, 5, e1666.Research output: Contribution to journal › Article › peer-review
Open AccessFile64 Citations (Scopus)239 Downloads (Pure) -
The soluble proteome phenotypes of ivermectin resistant and ivermectin susceptible Haemonchus contortus females compared
Hart, E. H., Morphew, R. M., Bartley, D. J., Millares, P., Wolf, B. T., Brophy, P. M. & Hamilton, J. V., Nov 2012, In: Veterinary Parasitology. 190, 1-2, p. 104-113 10 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
2011
Towards delineating functions within the fasciola secreted cathepsin L protease family by integrating in vivo based sub-proteomics and phylogenetics
Morphew, R. M., Wright, H. A., LaCourse, E. J., Porter, J., Barrett, J., Woods, D. J. & Brophy, P. M., 04 Jan 2011, In: PLoS Neglected Tropical Diseases. 5, 1, e-937.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)186 Downloads (Pure) -
2009
Proteomic analysis of the cacao pathogen Moniliophthora perniciosa
Pierre, S., Mur, L. A. J., Morphew, R., Hamilton, J., Scott, I. M. & Griffith, G. W., Nov 2009.Research output: Contribution to conference › Abstract
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The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function
Hamilton, C. M., Dowling, D. J., Loscher, C. E., Morphew, R. M., Brophy, P. M. & O'Neill, S. M., 01 Jun 2009, In: Infection and Immunity. 77, 6, p. 2488-2498 11 p.Research output: Contribution to journal › Article › peer-review
107 Citations (Scopus) -
2007
Comparative proteomics of excretory-secretory proteins released by the liver fluke Fasciola hepatica in sheep host bile and during in vitro culture ex host
Morphew, R. M., Wright, H. A., LaCourse, E. J., Woods, D. J. & Brophy, P. M., 01 Jun 2007, In: Molecular and Cellular Proteomics. 6, 6, p. 963-972 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile139 Citations (Scopus)50 Downloads (Pure) -
2006
Flatworm parasite proteomics
Morphew, R. M., Barrett, J. & Brophy, P. M., 2006, in. N, J. (ed.). CABI Publishing, p. 327-Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Citations (Scopus) -
Proteomic analysis of glutathione transferases from the liver fluke parasite, Fasciola hepatica
Chemale, G., Morphew, R. M., Moxon, J. V., Morassuti, A. L., LaCourse, E. J., Barrett, J., Johnston, D. A. & Brophy, P. M., 23 Dec 2006, In: Proteomics. 6, 23, p. 6263-6273 11 p.Research output: Contribution to journal › Article › peer-review
55 Citations (Scopus)