Research output per year
Research output per year
Project Details
| Status | Finished |
|---|---|
| Effective start/end date | 15 Apr 2013 → 14 Apr 2016 |
Funding
- Biotechnology and Biological Sciences Research Council (Funder reference unknown): £457,828.00
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
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Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Nov 2019, In: PLoS Neglected Tropical Diseases. 13, 11, 24 p., e0007693.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (SciVal)133 Downloads (Pure) -
Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni
Geyer, K., Munshi, S. E., Whiteland, H., Fernandez-Fuentes, N., Phillips, D. & Hoffmann, K., 28 Jun 2018, In: PLOS Pathogens. 14, 6, e1007107.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (SciVal)152 Downloads (Pure) -
The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities
Geyer, K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., Chaparro, C., Swain, M. & Hoffmann, K., 01 Aug 2018, In: International Journal for Parasitology: Drugs and Drug Resistance. 8, 2, p. 213-222 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (SciVal)144 Downloads (Pure) -
(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach
Cosseau, C., Wolkenhauer, O., Padalino, G., Geyer, K., Hoffmann, K. & Grunau, C., 01 Apr 2017, In: Trends in Parasitology. 33, 4, p. 285-294 10 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile22 Citations (SciVal)150 Downloads (Pure) -
The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni
Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S. E., Grunau, C., Yoshino, T. P. & Hoffmann, K., 16 May 2017, In: PLoS Neglected Tropical Diseases. 11, 5, 29 p., e0005246.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (SciVal)164 Downloads (Pure) -
Whole genome analysis of a schistosomiasis-transmitting freshwater snail
Adema, C. M., Hillier, L. W., Jones, C. S., Loker, E. S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L. R., Arican-Goktas, H. D., Assis, J. G., Baba, E. H., Baron, O. L., Bayne, C. J., Bickham-Wright, U., Biggar, K. K., Blouin, M., Bonning, B. C., Botka, C., & 97 others, 16 May 2017, In: Nature Communications. 8, p. 15451 15451 (2017).Research output: Contribution to journal › Article › peer-review
Open AccessFile157 Citations (SciVal)125 Downloads (Pure) -
DISMISS: detection of stranded methylation in MeDIP-Seq data
Niazi, U., Geyer, K. K., Vickers, M. J., Hoffmann, K. & Swain, M., 29 Jul 2016, In: BMC Bioinformatics. 17, 295.Research output: Contribution to journal › Article › peer-review
Open AccessFile133 Downloads (Pure) -
Cytosine methylation is a conserved epigenetic feature found throughout the phylum Platyhelminthes
Geyer, K. K., Chalmers, I. W., MacKintosh, N. D., Hirst, J. E., Geoghegan, R., Badets, M., Brophy, P. M., Brehm, K. & Hoffmann, K. F., 09 Jul 2013, In: BMC Genomics. 14, 462.Research output: Contribution to journal › Article › peer-review
Open AccessFile149 Downloads (Pure)
Activities
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Scientific seminar delivered to staff and students at Leiden University Medical Center, the Netherlands,
Karl Hoffmann (Participant)
2017Activity: Participating in or organising an event › Workshop, Seminar, or Course
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Life Sciences Research Network Wales
Karl Hoffmann (Participant)
30 Nov 2016 → 01 Dec 2016Activity: Participating in or organising an event › Conference
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Keystone Symposia
Karl Hoffmann (Participant)
24 Jan 2016 → 26 Jan 2016Activity: Participating in or organising an event › Conference
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Liverpool School of Tropical Medicine
Karl Hoffmann (Visiting researcher)
2016Activity: Visiting an external institution › Visiting an external academic institution
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University of Manchester
Karl Hoffmann (Visiting researcher)
2016Activity: Visiting an external institution › Visiting an external academic institution
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International Flatworm Biology Symposium
Kathrin Karola Geyer (Participant), Kezia Whatley (Participant) & Karl Hoffmann (Participant)
03 Aug 2015Activity: Participating in or organising an event › Conference
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Cardiff University
Karl Hoffmann (Host)
Jan 2015 → Apr 2015Activity: Hosting a visitor › Hosting an academic visitor
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Penglais School Visit and lecture on Genomics as part of the Genetics Roadshow
Karl Hoffmann (Speaker)
10 Apr 2013Activity: Talk or presentation › Oral presentation
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British Society for Parasitology Spring Meeting 2013
Fanny Nowacki (Participant), Joan Edwards (Participant), Kathrin Karola Geyer (Participant), Kezia Whatley (Participant) & Karl Hoffmann (Participant)
09 Apr 2013 → Apr 2015Activity: Participating in or organising an event › Conference
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Flatworm DNA methylation: deciphering the mark and characterising the machinery.
Karl Hoffmann (Speaker)
2013 → 2015Activity: Talk or presentation › Oral presentation
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Edinburgh University
Fanny Nowacki (Host)
2013Activity: Hosting a visitor › Hosting an academic visitor