β-Carbonyl substituted glutathione conjugates as inhibitors of O. Volvulus GST2

Peter Brophy, Alison M. Campbell, Annamaria J. van Eldik, Paul Teesdale-Spittle, Eva Liebau, Meng F. Wang

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

A series of β-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human πGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human π-GST of greater than 10-fold has been achieved
Original languageEnglish
Pages (from-to)979-981
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number9
DOIs
Publication statusPublished - 01 May 2000

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