TY - JOUR
T1 - β-Carbonyl substituted glutathione conjugates as inhibitors of O. Volvulus GST2
AU - Brophy, Peter
AU - Campbell, Alison M.
AU - van Eldik, Annamaria J.
AU - Teesdale-Spittle, Paul
AU - Liebau, Eva
AU - Wang, Meng F.
PY - 2000/5/1
Y1 - 2000/5/1
N2 - A series of β-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human πGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human π-GST of greater than 10-fold has been achieved
AB - A series of β-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human πGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human π-GST of greater than 10-fold has been achieved
UR - http://www.scopus.com/inward/record.url?scp=0034194354&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(00)00142-6
DO - 10.1016/S0960-894X(00)00142-6
M3 - Article
SN - 0960-894X
VL - 10
SP - 979
EP - 981
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 9
ER -