β-Carbonyl substituted glutathione conjugates as inhibitors of O. Volvulus GST2

Peter Brophy; Alison M. Campbell; Annamaria J. van Eldik; Paul Teesdale-Spittle; Eva Liebau; Meng F. Wang

doi:10.1016/S0960-894X(00)00142-6

β-Carbonyl substituted glutathione conjugates as inhibitors of O. Volvulus GST2

Peter Brophy
, Alison M. Campbell
, Annamaria J. van Eldik
, Paul Teesdale-Spittle
, Eva Liebau
, Meng F. Wang

Institute of Biological, Environmental, and Rural Sciences

De Montfort University
Bernhard Nocht Institute for Tropical Medicine

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A series of β-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human πGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human π-GST of greater than 10-fold has been achieved

Original language	English
Pages (from-to)	979-981
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	9
DOIs	https://doi.org/10.1016/S0960-894X(00)00142-6
Publication status	Published - 01 May 2000

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abstract = "A series of β-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human πGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human π-GST of greater than 10-fold has been achieved",

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AU - Brophy, Peter

AU - Campbell, Alison M.

AU - van Eldik, Annamaria J.

AU - Teesdale-Spittle, Paul

AU - Liebau, Eva

AU - Wang, Meng F.

PY - 2000/5/1

Y1 - 2000/5/1

N2 - A series of β-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human πGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human π-GST of greater than 10-fold has been achieved

AB - A series of β-carbonyl substituted glutathione conjugates were prepared and evaluated as inhibitors of OvGST2. Their specificity for the parasite derived protein was assessed through comparison with their inhibition of human πGST. Inhibition of OvGST2 has been demonstrated at low micromolar concentrations for these conjugates and selectivity for OvGST2 over human π-GST of greater than 10-fold has been achieved

UR - https://www.scopus.com/pages/publications/0034194354

U2 - 10.1016/S0960-894X(00)00142-6

DO - 10.1016/S0960-894X(00)00142-6

M3 - Article

SN - 0960-894X

VL - 10

SP - 979

EP - 981

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 9

ER -

β-Carbonyl substituted glutathione conjugates as inhibitors of O. Volvulus GST2

Abstract

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