1,25-Dihydroxyvitamin D3 and Development of Tuberculosis in Cattle

S. G. Rhodes, L. A. Terry, J. Hope, R. G. Hewinson, H. M. Vordermeier*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (SciVal)

Abstract

This report describes the presence and activity of 1,25-dihydroxyvitamin D3 (1,25-D3) in experimental bovine tuberculosis. Animals that went on to develop tuberculous lesions exhibited a rapid transient increase in serum 1,25-D3 within the first 2 weeks following infection with Mycobacterium bovis, 1,25-D3-positive mononuclear cells were later identified in all tuberculous granulomas by immunohistochemical staining of postmortem lymph node tissue. These results suggest a role for 1,25-D3 both at the onset of infection and in the development of the granuloma in these infected animals. Using a monoclonal antibody to the vitamin D receptor (VDR) as a VDR agonist, we confirmed that activation of the vitamin D pathway profoundly depresses antigen-specific, but not mitogenic, bovine peripheral blood T-cell responses (proliferation and gamma interferon production). Investigation of the mechanism of this suppression showed that the VDR antibody modified the expression of CD80 by accessory cells, such that a significant positive correlation between T-cell proliferation and accessory cell CD80 emerged.

Original languageEnglish
Pages (from-to)1129-1135
Number of pages7
JournalClinical and Diagnostic Laboratory Immunology
Volume10
Issue number6
DOIs
Publication statusPublished - 01 Nov 2003

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