A new diagnostic tool for neurocysticercosis is a member of a cestode specific hydrophobic ligand binding protein family

Nahid Saghir, Phillip J. Conde, Peter Brophy, John Barrett

Research output: Contribution to journalArticlepeer-review

30 Citations (SciVal)

Abstract

A protein of unknown function has been identified as a key serological tool for diagnosis of human tapeworm neurocysticercosis, a major worldwide neurological disease. Our own sequence analysis predicts that this protein is a member of a newly identified cestode specific oligomeric hydrophobic ligand binding protein family. In this report, using a rat cestode model, we confirm that homologues of this protein can bind fatty acids and their derivatives, and thus suggest a biological function for this key diagnostic tool
Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalFEBS Letters
Volume487
Issue number2
DOIs
Publication statusPublished - 29 Dec 2000

Keywords

  • Cestoda
  • Diagnosis
  • Hydrophobic ligand binding protein
  • Hymenolepis diminuta

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