A new diagnostic tool for neurocysticercosis is a member of a cestode specific hydrophobic ligand binding protein family

Nahid Saghir; Phillip J. Conde; Peter Brophy; John Barrett

doi:10.1016/S0014-5793(00)02191-8

A new diagnostic tool for neurocysticercosis is a member of a cestode specific hydrophobic ligand binding protein family

Nahid Saghir, Phillip J. Conde, Peter Brophy, John Barrett

Institute of Biological, Environmental, and Rural Sciences

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A protein of unknown function has been identified as a key serological tool for diagnosis of human tapeworm neurocysticercosis, a major worldwide neurological disease. Our own sequence analysis predicts that this protein is a member of a newly identified cestode specific oligomeric hydrophobic ligand binding protein family. In this report, using a rat cestode model, we confirm that homologues of this protein can bind fatty acids and their derivatives, and thus suggest a biological function for this key diagnostic tool

Original language	English
Pages (from-to)	181-184
Number of pages	4
Journal	FEBS Letters
Volume	487
Issue number	2
DOIs	https://doi.org/10.1016/S0014-5793(00)02191-8
Publication status	Published - 29 Dec 2000

Keywords

Cestoda
Diagnosis
Hydrophobic ligand binding protein
Hymenolepis diminuta

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0014-5793(00)02191-8

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abstract = "A protein of unknown function has been identified as a key serological tool for diagnosis of human tapeworm neurocysticercosis, a major worldwide neurological disease. Our own sequence analysis predicts that this protein is a member of a newly identified cestode specific oligomeric hydrophobic ligand binding protein family. In this report, using a rat cestode model, we confirm that homologues of this protein can bind fatty acids and their derivatives, and thus suggest a biological function for this key diagnostic tool",

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AU - Saghir, Nahid

AU - Conde, Phillip J.

AU - Brophy, Peter

AU - Barrett, John

PY - 2000/12/29

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N2 - A protein of unknown function has been identified as a key serological tool for diagnosis of human tapeworm neurocysticercosis, a major worldwide neurological disease. Our own sequence analysis predicts that this protein is a member of a newly identified cestode specific oligomeric hydrophobic ligand binding protein family. In this report, using a rat cestode model, we confirm that homologues of this protein can bind fatty acids and their derivatives, and thus suggest a biological function for this key diagnostic tool

AB - A protein of unknown function has been identified as a key serological tool for diagnosis of human tapeworm neurocysticercosis, a major worldwide neurological disease. Our own sequence analysis predicts that this protein is a member of a newly identified cestode specific oligomeric hydrophobic ligand binding protein family. In this report, using a rat cestode model, we confirm that homologues of this protein can bind fatty acids and their derivatives, and thus suggest a biological function for this key diagnostic tool

KW - Cestoda

KW - Diagnosis

KW - Hydrophobic ligand binding protein

KW - Hymenolepis diminuta

UR - https://www.scopus.com/pages/publications/0034731315

U2 - 10.1016/S0014-5793(00)02191-8

DO - 10.1016/S0014-5793(00)02191-8

M3 - Article

SN - 0014-5793

VL - 487

SP - 181

EP - 184

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

A new diagnostic tool for neurocysticercosis is a member of a cestode specific hydrophobic ligand binding protein family

Abstract

Keywords

UN SDGs

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