A petri net model of granulomatous inflammation

Luca Albergante*, Jon Timmis, Paul Andrews, Lynette Beattie, Paul M. Kaye

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)


Leishmania donovani is an obligate intracellular parasite responsible for the systemic disease visceral leishmaniasis. During the course of the disease, the parasite is found in the spleen, liver and bone marrow. Characteristic of the liver immune response to leishmaniasis is a type of inflammation ("ggranulomatous inflammation") that results in the formation of granulomas, structures comprised of an infiltrate of mononuclear cells surrounding a core of infected macrophages. Granulomas help limit the spread of infection and facilitate the killing of parasites. Liver-resident macrophages (Kupffer cells) are able to spontaneously kill many infectious agents, but L. donovani is capable of reproducing inside these cells. Activation of Kupffer cells is required to turn them from host cell to a cell that is able to kill intracellular L. donovani . This process of activation is regulated by cytokines (notably IFNγ) produced by many different types of leukocytes, including natural killer (NK) cells ([1]), CD4+ and CD8+ T cells ([2]), and NKT cells ([3]).

Original languageEnglish
Title of host publicationArtificial Immune Systems - 9th International Conference, ICARIS 2010, Proceedings
Number of pages3
Publication statusPublished - 2010
Event9th International Conference on Artificial Immune Systems, ICARIS 2010 - Edinburgh, United Kingdom of Great Britain and Northern Ireland
Duration: 26 Jul 201029 Jul 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6209 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference9th International Conference on Artificial Immune Systems, ICARIS 2010
Country/TerritoryUnited Kingdom of Great Britain and Northern Ireland
Period26 Jul 201029 Jul 2010

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