A structure-motivated hybrid machine for prediction of biological activity of chemical compounds

Amit Kumar Mishra, Om Prasad Patri

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)

Abstract

In this work we propose a hybrid learning machine, combining artificial neural networks (ANNs) and binary decision trees, to predict quantitative structure activity relationships (QSARs). This approach directly uses the structural cues from chemical compounds and has been validated for the two significant prediction problems, viz. regression and classification. For regression analysis we show the utility of the algorithm in predicting anti-HIV-1 activity of a class of 80 chemical compounds (called HEPT derivatives) found to be potential HIV-1 inhibitors. For classification the algorithm is used to predict hepatocarcinogenicity of 55 chemicals from the Carcinogenic Potency Database (CPDB). Hence, the proposed algorithm has the potential to be used in a generic form for a wider variety of similar problems. Each compound in both the datasets was cycled between the training, validation and test sets. The hybrid machine was tested on data which were not in the training set. The results were compared with the popular ANN based classifier proposed in literature (without using the hybrid approach) and the hybrid machine was found to perform better for both the prediction problems.

Original languageEnglish
Title of host publicationProceedings of the 2010 Annual IEEE India Conference
Subtitle of host publicationGreen Energy, Computing and Communication, INDICON 2010
PublisherIEEE Press
Number of pages4
ISBN (Electronic)978-1-4244-9074-5
ISBN (Print)978-1-4244-9072-1
DOIs
Publication statusPublished - 17 Dec 2010
Externally publishedYes
Event2010 Annual IEEE India Conference: Green Energy, Computing and Communication, INDICON 2010 - Kolkata, India
Duration: 17 Dec 201019 Dec 2010

Publication series

NameProceedings of the 2010 Annual IEEE India Conference: Green Energy, Computing and Communication, INDICON 2010

Conference

Conference2010 Annual IEEE India Conference: Green Energy, Computing and Communication, INDICON 2010
Country/TerritoryIndia
CityKolkata
Period17 Dec 201019 Dec 2010

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