Agent-based modeling in systems pharmacology

J. Cosgrove, J. Butler, K. Alden, M. Read, V. Kumar, L. Cucurull-Sanchez, J. Timmis*, M. Coles

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Citations (SciVal)

Abstract

Modeling and simulation (M&S) techniques provide a platform for knowledge integration and hypothesis testing to gain insights into biological systems that would not be possible a priori. Agent-based modeling (ABM) is an M&S technique that focuses on describing individual components rather than homogenous populations. This tutorial introduces ABM to systems pharmacologists, using relevant case studies to highlight how ABM-specific strengths have yielded success in the area of preclinical mechanistic modeling.

Original languageEnglish
Pages (from-to)615-629
Number of pages15
JournalCPT: Pharmacometrics and Systems Pharmacology
Volume4
Issue number11
DOIs
Publication statusPublished - 01 Nov 2015
Externally publishedYes

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