Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum

A. Kato; M. Yasui; N. Yano; Y. Kawata; K. Moriki; I. Adachi; J. Hollinshead; R. J. Nash

doi:10.1016/j.phytol.2008.12.003

Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum

A. Kato
, M. Yasui
, N. Yano
, Y. Kawata
, K. Moriki
, I. Adachi
, J. Hollinshead
, R. J. Nash

Institute of Biological, Environmental, and Rural Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.

Original language	English
Pages (from-to)	77-80
Number of pages	4
Journal	Phytochemistry Letters
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/j.phytol.2008.12.003
Publication status	Published - 2009

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title = "Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum",

abstract = "Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.",

author = "A. Kato and M. Yasui and N. Yano and Y. Kawata and K. Moriki and I. Adachi and J. Hollinshead and Nash, \{R. J.\}",

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doi = "10.1016/j.phytol.2008.12.003",

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T1 - Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum

AU - Kato, A.

AU - Yasui, M.

AU - Yano, N.

AU - Kawata, Y.

AU - Moriki, K.

AU - Adachi, I.

AU - Hollinshead, J.

AU - Nash, R. J.

N1 - IMPF: 00.96 RONO: 00

PY - 2009

Y1 - 2009

N2 - Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.

AB - Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus 30a with an IC50 value of 969 μM but its N-oxide showed no inhibition of this enzyme. Sinomenine inhibited this enzyme in a noncompetitive manner with a Ki of 762 μM.

UR - http://hdl.handle.net/2160/8033

U2 - 10.1016/j.phytol.2008.12.003

DO - 10.1016/j.phytol.2008.12.003

M3 - Article

SN - 1876-7486

VL - 2

SP - 77

EP - 80

JO - Phytochemistry Letters

JF - Phytochemistry Letters

IS - 2

ER -

Alkaloids inhibiting l-histidine decarboxylase from Sinomenium acutum

Abstract

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