An alpha-glucoside of 1,4-dideoxy-1,4-imino-d-lyxitol with an eleven carbon side chain

A. Kato, J. Hollinshead, Y. Yamashita, S. Nakagawa, Y. Koike, I. Adachi, C. -. Y. Yu, G. W. J. Fleet, R. J. Nash

Research output: Contribution to journalArticlepeer-review

15 Citations (SciVal)

Abstract

As the result of a search for new potentially therapeutic iminosugars, the isolation and the identification of 1,4-dideoxy-1,4-imino-d-lyxital (DIL) glucoside bearing the 1,2,11-trihydroxyundec-4-ene side chains from the roots of Adenophora triphylla is described. This iminosugar was a powerful and selective inhibitor of coffee bean a-galactosidase, with an IC50 value of 8uM.
Original languageEnglish
Pages (from-to)230-233
Number of pages4
JournalPhytochemistry Letters
Volume3
Issue number4
DOIs
Publication statusPublished - 2010

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