TY - JOUR
T1 - An alpha-glucoside of 1,4-dideoxy-1,4-imino-d-lyxitol with an eleven carbon side chain
AU - Kato, A.
AU - Hollinshead, J.
AU - Yamashita, Y.
AU - Nakagawa, S.
AU - Koike, Y.
AU - Adachi, I.
AU - Yu, C. -. Y.
AU - Fleet, G. W. J.
AU - Nash, R. J.
N1 - IMPF: 01.36
RONO: 00
PY - 2010
Y1 - 2010
N2 - As the result of a search for new potentially therapeutic iminosugars, the isolation and the identification of 1,4-dideoxy-1,4-imino-d-lyxital (DIL) glucoside bearing the 1,2,11-trihydroxyundec-4-ene side chains from the roots of Adenophora triphylla is described. This iminosugar was a powerful and selective inhibitor of coffee bean a-galactosidase, with an IC50 value of 8uM.
AB - As the result of a search for new potentially therapeutic iminosugars, the isolation and the identification of 1,4-dideoxy-1,4-imino-d-lyxital (DIL) glucoside bearing the 1,2,11-trihydroxyundec-4-ene side chains from the roots of Adenophora triphylla is described. This iminosugar was a powerful and selective inhibitor of coffee bean a-galactosidase, with an IC50 value of 8uM.
UR - http://hdl.handle.net/2160/8044
U2 - 10.1016/j.phytol.2010.08.006
DO - 10.1016/j.phytol.2010.08.006
M3 - Article
VL - 3
SP - 230
EP - 233
JO - Phytochemistry Letters
JF - Phytochemistry Letters
IS - 4
ER -