An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Liam Evans, John N. Hedger, David Brayford, Michael Stavri, Eileen Smith, Gemma O'Donnell, Alexander I. Gray, Gareth W. Griffith, Simon Gibbons

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15 Citations (SciVal)

Abstract

A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml. Bioautography-led isolation of an extract of the fermentation of the mitosporic fungus Acremonium crotocinigenum resulted in the characterisation of the fusidane triterpene related to fusidic acid, 1, as the major anti-staphylococcal natural product. Against efflux strains, 1 had MIC values of 16 μg/ml.
Original languageEnglish
Pages (from-to)2110-2114
Number of pages5
JournalPhytochemistry
Volume67
Issue number19
Early online date22 Aug 2006
DOIs
Publication statusPublished - 01 Oct 2006

Keywords

  • Acrmonium crotocinigenum
  • Fusidane triterpene
  • fusidic acid
  • antibacterial
  • MRSA
  • MDR
  • Staphylococcus aureus

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