An instrument for the acquisition and analysis of the nonlinear dielectric spectra of biological samples

A. Jones; J. J. Rowland; A. M. Woodward; D. B. Kell

doi:10.1177/014233129701900502

An instrument for the acquisition and analysis of the nonlinear dielectric spectra of biological samples

A. Jones
, J. J. Rowland
, A. M. Woodward
, D. B. Kell

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Nonlinear dielectric spectroscopy is, potentially, a powerful non-invasive method of monitoring biological cell activity, with possible applications in biotechnology and in medicine. This paper describes the design and implementation of an integrated instrument for obtaining and analysing the nonlinear dielectric spectra of biological cell suspensions. The instrument is based on an IBMcOmpatible personal computer equiped with an AT&T digital signal processor and 16-bit analogue I/O. It allows collection of resultant power spectra in real time during optimal time sweeps over a wide range of excitation voltages and frequencies. Further analysis of the sets of spectra is undertaken by means of mutivariate calibration. Examples are included of results obtained and it concludes with a brief discussion of the present limitations of the method.

Original language	English
Pages (from-to)	223-230
Number of pages	8
Journal	Transactions of the Institute of Measurement & Control
Volume	19
Issue number	5
DOIs	https://doi.org/10.1177/014233129701900502
Publication status	Published - Dec 1997

Keywords

fermentation
instrumentation
multivariate calibration
Nonlinear dielectrics

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title = "An instrument for the acquisition and analysis of the nonlinear dielectric spectra of biological samples",

abstract = "Nonlinear dielectric spectroscopy is, potentially, a powerful non-invasive method of monitoring biological cell activity, with possible applications in biotechnology and in medicine. This paper describes the design and implementation of an integrated instrument for obtaining and analysing the nonlinear dielectric spectra of biological cell suspensions. The instrument is based on an IBMcOmpatible personal computer equiped with an AT\&T digital signal processor and 16-bit analogue I/O. It allows collection of resultant power spectra in real time during optimal time sweeps over a wide range of excitation voltages and frequencies. Further analysis of the sets of spectra is undertaken by means of mutivariate calibration. Examples are included of results obtained and it concludes with a brief discussion of the present limitations of the method.",

keywords = "fermentation, instrumentation, multivariate calibration, Nonlinear dielectrics",

author = "A. Jones and Rowland, \{J. J.\} and Woodward, \{A. M.\} and Kell, \{D. B.\}",

year = "1997",

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AU - Jones, A.

AU - Rowland, J. J.

AU - Woodward, A. M.

AU - Kell, D. B.

PY - 1997/12

Y1 - 1997/12

N2 - Nonlinear dielectric spectroscopy is, potentially, a powerful non-invasive method of monitoring biological cell activity, with possible applications in biotechnology and in medicine. This paper describes the design and implementation of an integrated instrument for obtaining and analysing the nonlinear dielectric spectra of biological cell suspensions. The instrument is based on an IBMcOmpatible personal computer equiped with an AT&T digital signal processor and 16-bit analogue I/O. It allows collection of resultant power spectra in real time during optimal time sweeps over a wide range of excitation voltages and frequencies. Further analysis of the sets of spectra is undertaken by means of mutivariate calibration. Examples are included of results obtained and it concludes with a brief discussion of the present limitations of the method.

AB - Nonlinear dielectric spectroscopy is, potentially, a powerful non-invasive method of monitoring biological cell activity, with possible applications in biotechnology and in medicine. This paper describes the design and implementation of an integrated instrument for obtaining and analysing the nonlinear dielectric spectra of biological cell suspensions. The instrument is based on an IBMcOmpatible personal computer equiped with an AT&T digital signal processor and 16-bit analogue I/O. It allows collection of resultant power spectra in real time during optimal time sweeps over a wide range of excitation voltages and frequencies. Further analysis of the sets of spectra is undertaken by means of mutivariate calibration. Examples are included of results obtained and it concludes with a brief discussion of the present limitations of the method.

KW - fermentation

KW - instrumentation

KW - multivariate calibration

KW - Nonlinear dielectrics

UR - https://www.scopus.com/pages/publications/0031316036

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DO - 10.1177/014233129701900502

M3 - Article

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SN - 0142-3312

VL - 19

SP - 223

EP - 230

JO - Transactions of the Institute of Measurement & Control

JF - Transactions of the Institute of Measurement & Control

IS - 5

ER -

An instrument for the acquisition and analysis of the nonlinear dielectric spectra of biological samples

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