An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance

Steven Lewis Kelly; David Christopher Lamb; Timothy H. Marczylo; Colin J. Jackson; Diane Elizabeth Kelly; Michel Cannieux; C. Ugochukwu; Darren Greetham

doi:10.1042/bst0290122

An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance

Steven Lewis Kelly, David Christopher Lamb, Timothy H. Marczylo, Colin J. Jackson, Diane Elizabeth Kelly, Michel Cannieux, C. Ugochukwu, Darren Greetham

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Cytochrome P450 51 (CYP51) is sterol 14α-demethylase, known also as Erg11p in yeast. First studied in yeast, where it is one of three CYPs in the genome, it has subsequently gained attention as the only CYP found so far in different kingdoms of life. As such it is central to considerations of CYP evolution. Recent use of CYP51-inhibiting antifungal drugs, such as fluconazole, has also been associated with dramatic CYP51 evolution to numerous resistant forms in fungal pathogens. CYP51 has also been discovered in mycobacteria where antifungal azoles have effect and might be of value against tuberculosis. Evolutionary and therapeutic aspects of CYP51 studies are discussed.

Original language	English
Pages (from-to)	122-128
Number of pages	7
Journal	Biochemical Society Transactions
Volume	29
Issue number	2
DOIs	https://doi.org/10.1042/bst0290122
Publication status	Published - 2001

Keywords

Azole
Cytochrome P450 51
Fungi
Mycobacteria
Sterol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1042/bst0290122

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abstract = "Cytochrome P450 51 (CYP51) is sterol 14α-demethylase, known also as Erg11p in yeast. First studied in yeast, where it is one of three CYPs in the genome, it has subsequently gained attention as the only CYP found so far in different kingdoms of life. As such it is central to considerations of CYP evolution. Recent use of CYP51-inhibiting antifungal drugs, such as fluconazole, has also been associated with dramatic CYP51 evolution to numerous resistant forms in fungal pathogens. CYP51 has also been discovered in mycobacteria where antifungal azoles have effect and might be of value against tuberculosis. Evolutionary and therapeutic aspects of CYP51 studies are discussed.",

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AU - Kelly, Steven Lewis

AU - Lamb, David Christopher

AU - Marczylo, Timothy H.

AU - Jackson, Colin J.

AU - Kelly, Diane Elizabeth

AU - Cannieux, Michel

AU - Ugochukwu, C.

AU - Greetham, Darren

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KW - Azole

KW - Cytochrome P450 51

KW - Fungi

KW - Mycobacteria

KW - Sterol

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JF - Biochemical Society Transactions

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ER -

An old activity in the cytochrome P450 superfamily (CYP51) and a new story of drugs and resistance

Abstract

Keywords

UN SDGs

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