Association mapping of partitioning loci in barley

James Cockram, Jon White, Fiona J. Leigh, Vincent J. Lea, Elena Chiapparino, David A. Laurie, Ian J. Mackay, Wayne Powell, Donal M. O'Sullivan

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Association mapping, initially developed in human disease genetics, is now being applied to plant species. The model species Arabidopsis provided some of the first examples of association mapping in plants, identifying previously cloned flowering time genes, despite high population sub-structure. More recently, association genetics has been applied to barley, where breeding activity has resulted in a high degree of population sub-structure. A major genotypic division within barley is that between winter- and spring-sown varieties, which differ in their requirement for vernalization to promote subsequent flowering. To date, all attempts to validate association genetics in barley by identifying major flowering time loci that control vernalization requirement (VRN-H1 and VRN-H2) have failed. Here, we validate the use of association genetics in barley by identifying VRN-H1 and VRN-H2, despite their prominent role in determining population sub-structure.
Original languageEnglish
JournalBMC Genetics
Issue number16
Publication statusPublished - 18 Feb 2008


  • linkage disequilibrium
  • association mappiing
  • growth habit
  • vernalization requirement
  • genomic control


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