Association of adult lung function with accelerated biological aging

Faisal I Rezwan; Medea Imboden; Andre F.S. Amaral; Matthias Wielscher; Ayoung Jeong; Kai Triebner; Francisco Gómez Real; Marjo-Riitta Jarvelin; Deborah Jarvis; Nicole M. Probst-Hensch; John W. Holloway

doi:10.18632/aging.102639

Association of adult lung function with accelerated biological aging

Faisal I Rezwan^*, Medea Imboden, Andre F.S. Amaral, Matthias Wielscher, Ayoung Jeong, Kai Triebner, Francisco Gómez Real, Marjo-Riitta Jarvelin, Deborah Jarvis, Nicole M. Probst-Hensch, John W. Holloway^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed.

AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10-4; Intrinsic Epigenetic AA:P-value=2x10-4) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10-17).

This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.

Original language	English
Pages (from-to)	518-542
Number of pages	25
Journal	Aging
Volume	12
Issue number	1
DOIs	https://doi.org/10.18632/aging.102639
Publication status	Published - 11 Jan 2020
Externally published	Yes

Keywords

Age acceleration
DNA methylation
Epigenetic clock
Lung function
Respiratory health
Lung/metabolism
Meta-Analysis as Topic
Age Factors
Cross-Sectional Studies
Epigenesis, Genetic
Humans
Middle Aged
Male
Aging/physiology
Sex Factors
Biomarkers
Adult
Female
Respiratory Function Tests

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title = "Association of adult lung function with accelerated biological aging",

abstract = "Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed.AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10-4; Intrinsic Epigenetic AA:P-value=2x10-4) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10-17).This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.",

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author = "Rezwan, {Faisal I} and Medea Imboden and Amaral, {Andre F.S.} and Matthias Wielscher and Ayoung Jeong and Kai Triebner and Real, {Francisco G{\'o}mez} and Marjo-Riitta Jarvelin and Deborah Jarvis and Probst-Hensch, {Nicole M.} and Holloway, {John W.}",

note = "Publisher Copyright: {\textcopyright} Rezwan et al.",

year = "2020",

month = jan,

day = "11",

doi = "10.18632/aging.102639",

language = "English",

volume = "12",

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T1 - Association of adult lung function with accelerated biological aging

AU - Rezwan, Faisal I

AU - Imboden, Medea

AU - Amaral, Andre F.S.

AU - Wielscher, Matthias

AU - Jeong, Ayoung

AU - Triebner, Kai

AU - Real, Francisco Gómez

AU - Jarvelin, Marjo-Riitta

AU - Jarvis, Deborah

AU - Probst-Hensch, Nicole M.

AU - Holloway, John W.

N1 - Publisher Copyright: © Rezwan et al.

PY - 2020/1/11

Y1 - 2020/1/11

N2 - Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed.AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10-4; Intrinsic Epigenetic AA:P-value=2x10-4) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10-17).This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.

AB - Lung function, strongly associated with morbidity and mortality, decreases with age. This study examines whether poor adult lung function is associated with age accelerations (AAs). DNA methylation (DNAm) based AAs, lifespan predictors (GrimAge and plasminogen activator inhibitor 1-PAI1) and their related age-adjusted measures were estimated from peripheral blood at two time points (8-to-11 years apart) in adults from two cohorts: SAPALDIA (n=987) and ECRHS (n=509). Within each cohort and stratified by gender (except for estimators from GrimAge and PAI1), AAs were used as predictors in multivariate linear regression with cross-sectional lung function parameters, and in covariate-adjusted mixed linear regression with longitudinal change in lung function and meta-analysed.AAs were found cross-sectionally associated with lower mean FEV1 (Forced Expiratory Volume in one second) (AA-residuals:P-value=4x10-4; Intrinsic Epigenetic AA:P-value=2x10-4) in females at the follow-up time point only, and the same trend was observed for FVC (Forced Vital Capacity). Both lifespan and plasma level predictors were observed strongly associated with lung function decline and the decline was stronger in the follow-up time points (strongest association between FEV1 and DNAmAge GrimAge:P-value=1.25x10-17).This study suggests that DNAm based lifespan and plasma level predictors can be utilised as important factors to assess lung health in adults.

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KW - Respiratory health

KW - Lung/metabolism

KW - Meta-Analysis as Topic

KW - Age Factors

KW - Cross-Sectional Studies

KW - Epigenesis, Genetic

KW - Humans

KW - Middle Aged

KW - Male

KW - Aging/physiology

KW - Sex Factors

KW - Biomarkers

KW - Adult

KW - Female

KW - Respiratory Function Tests

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U2 - 10.18632/aging.102639

DO - 10.18632/aging.102639

M3 - Article

C2 - 31926111

SN - 1945-4589

VL - 12

SP - 518

EP - 542

JO - Aging

JF - Aging

IS - 1

ER -

Association of adult lung function with accelerated biological aging

Abstract

Keywords

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