Atomic force microscopy-based indentation of cells: Modelling the effect of a pericellular coat

Ivan Argatov, Xiaoqing Jin, Gennady Mishuris*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (SciVal)
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Abstract

A simple analytical model is built up to account for the interface deformation effect in a spherical atomic force microscopy (AFM)-based quasi-static indentation of a living cell covered with a pericellular brush. The compression behaviour of the pericellular coat is described using the Alexander-de Gennes model that allows for nonlinear deformation. An approximate second-order relation between contact force and indenter displacement is obtained in implicit form, using the Hertzian solution as a first-order approximation. A method of fitting the indentation brush/cell model to experimental data is suggested based on the non-dimensionalized version of the displacement-force relation in the parametric form and illustrated with a specific example of AFM raw data taken from the literature.

Original languageEnglish
Article number20220857
Number of pages10
JournalInterface
Volume20
Issue number199
DOIs
Publication statusPublished - 22 Feb 2023

Keywords

  • Life Sciences–Mathematics interface
  • Research articles
  • atomic force microscopy indentation
  • living cell
  • pericellular brush
  • mathematical modelling

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