TY - JOUR
T1 - BCG vaccination against tuberculosis in European badgers (Meles meles)
T2 - A review
AU - Robinson, Philip A.
AU - Corner, Leigh A.L.
AU - Courcier, Emily A.
AU - McNair, Jim
AU - Artois, Marc
AU - Menzies, Fraser D.
AU - Abernethy, Darrell A.
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Tuberculosis (TB) is a significant animal health problem in many parts of the world, and reservoirs of infection in wild animals complicate disease control efforts in farmed livestock, particularly cattle. Badgers (Meles meles) are a significant wildlife reservoir of Mycobacterium bovis infection for cattle in the United Kingdom (UK) and Republic of Ireland (ROI). Vaccination of badgers using an M. bovis strain bacille Calmette-Guérin (BCG) vaccine could potentially be an option in the national TB eradication strategy. Wildlife vaccination has been used successfully for other diseases in wildlife species, and may have a role to play in reducing M. bovis transmission at the wildlife-livestock interface. Research to date has provided evidence that BCG is protective in badgers, and a parenteral badger BCG vaccine has been licensed in the UK. Further research is required to develop effective strategies for vaccine deployment and to determine the effect of badger vaccination on cattle TB incidence.
AB - Tuberculosis (TB) is a significant animal health problem in many parts of the world, and reservoirs of infection in wild animals complicate disease control efforts in farmed livestock, particularly cattle. Badgers (Meles meles) are a significant wildlife reservoir of Mycobacterium bovis infection for cattle in the United Kingdom (UK) and Republic of Ireland (ROI). Vaccination of badgers using an M. bovis strain bacille Calmette-Guérin (BCG) vaccine could potentially be an option in the national TB eradication strategy. Wildlife vaccination has been used successfully for other diseases in wildlife species, and may have a role to play in reducing M. bovis transmission at the wildlife-livestock interface. Research to date has provided evidence that BCG is protective in badgers, and a parenteral badger BCG vaccine has been licensed in the UK. Further research is required to develop effective strategies for vaccine deployment and to determine the effect of badger vaccination on cattle TB incidence.
KW - Bacille Calmette-Guérin
KW - Meles meles
KW - Mycobacterium bovis
KW - Wildlife vaccination
UR - http://www.scopus.com/inward/record.url?scp=84861757061&partnerID=8YFLogxK
U2 - 10.1016/j.cimid.2012.01.009
DO - 10.1016/j.cimid.2012.01.009
M3 - Review Article
C2 - 22340983
AN - SCOPUS:84861757061
SN - 0147-9571
VL - 35
SP - 277
EP - 287
JO - Comparative Immunology, Microbiology and Infectious Diseases
JF - Comparative Immunology, Microbiology and Infectious Diseases
IS - 4
ER -
