Best Practices to Maximize the Use and Reuse of Quantitative and Systems Pharmacology Models: Recommendations From the United Kingdom Quantitative and Systems Pharmacology Network

Lourdes Cucurull-Sanchez*, Michael J. Chappell, Vijayalakshmi Chelliah, S. Y. Amy Cheung, Gianne Derks, Mark Penney, Alex Phipps, Rahuman S. Malik-Sheriff, Jon Timmis, Marcus J. Tindall, Piet H. van der Graaf, Paolo Vicini, James W.T. Yates

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (SciVal)

Abstract

The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermines the potential impact of QSP in academic, industrial, and regulatory frameworks. This article presents a minimum set of recommendations from the UK Quantitative and Systems Pharmacology Network (UK QSP Network) to guide QSP practitioners seeking to maximize their impact, and stakeholders considering the use of QSP models in their environment.

Original languageEnglish
Pages (from-to)259-272
Number of pages14
JournalCPT: Pharmacometrics and Systems Pharmacology
Volume8
Issue number5
DOIs
Publication statusPublished - May 2019

Keywords

  • Humans
  • Models, Biological
  • Parathyroid Hormone/adverse effects
  • Practice Guidelines as Topic
  • Reproducibility of Results
  • Systems Biology/standards
  • United Kingdom

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