Blending Active and Passive Digital Technology Methods to Improve Symptom Monitoring in Early Psychosis

Matteo Cella, Zhimin He, Clare Killikelly, Łukasz Okruszek, Shôn Lewis, Til Wykes

Research output: Contribution to journalArticlepeer-review

24 Citations (SciVal)
375 Downloads (Pure)

Abstract

Aims
Psychotic symptoms fluctuate over time and effective and regular monitoring may contribute to relapse prevention and improve long‐term outcomes. In this proof‐of‐concept study we test the feasibility, acceptability and potential usefulness of a novel digital method assessing the association between physiological signals and psychotic symptom distress.

Methods
Fifteen participants with first episode psychosis were asked to use a self‐assessment mobile phone application for psychotic symptom monitoring for 10 days while using a wrist worn device continuously recording heart rate variability (HRV) and electrodermal activity (EDA). We compared physiological activity when participants reported experiencing distressing and non‐distressing psychotic symptoms.

Results
Participants completed on average 76% of the mobile phone symptom assessments. When reporting distressing hallucinations and delusions participants had significantly higher EDA levels and non‐significant lower HRV values compared to when these symptoms were non‐distressing.

Conclusions
This study provides further evidence linking psychotic symptom's distress, as experienced in everyday life, and autonomic deregulation. This proof‐of‐concept study may lead to further longer‐term efforts to identify relapse biosignatures using automated methods based on passive monitoring. This method may allow for earlier interventions, contribute to improve relapse prevention and reduce symptoms interfering with recovery.
Original languageEnglish
Pages (from-to)1271-1275
Number of pages5
JournalEarly Intervention in Psychiatry
Volume13
Issue number5
Early online date28 Feb 2019
DOIs
Publication statusPublished - 12 Sept 2019

Keywords

  • autonomic
  • eHealth
  • mHealth
  • psychosis
  • schizophrenia
  • wearable
  • Heart Rate
  • Humans
  • Male
  • Young Adult
  • Monitoring, Physiologic/instrumentation
  • Delusions/diagnosis
  • Mobile Applications
  • Hallucinations/diagnosis
  • Adolescent
  • Adult
  • Diagnostic Self Evaluation
  • Female
  • Psychotic Disorders/diagnosis
  • Cell Phone
  • Early Diagnosis
  • Longitudinal Studies
  • Secondary Prevention/instrumentation

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