Bone marrow immunosuppression in Salmonella-infected mice is prolonged following influenza virus infection

Lisa Hyland*, Bernardo Villarreal-Ramos, Ben Clarke, Bas Baaten, Sam Hou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (SciVal)

Abstract

Objective. It has been shown previously that infection with diverse viruses induces alterations in bone marrow lineage-specific progenitor cells. As complications arising from secondary bacterial infections can adversely affect the host, we investigated whether virally induced hematological alterations could contribute to the enhanced illness observed in such cases. Materials and Methods. Mice were infected with influenza virus alone or influenza virus followed by a vaccine strain of Salmonella typhimurium. The effects on hematopoiesis were analyzed by fluorescein-activated cell sorting analysis and immunohistology. Results. Systemic Salmonella typhimurium infection induces depletion of bone marrow erythroid and lymphoid cells. The depletion lasted longer in mice that had been previously infected with influenza virus, compared with mice that had been previously treated with allantoic fluid. Although an increase in splenic lymphoid cells was apparent in the spleens of Salmonella-infected mice, the majority of cells in the enlarged spleens were found to be both immature and mature erythrocytes. Conclusion. These results show that bone marrow progenitor cell depletion induced by bacterial infection is prolonged following a viral infection. It is possible that hematological alterations may contribute to the enhanced clinical illness observed in consecutive viral:bacterial infections.

Original languageEnglish
Pages (from-to)1477-1485
Number of pages9
JournalExperimental Hematology
Volume33
Issue number12
DOIs
Publication statusPublished - 01 Dec 2005

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