TY - JOUR
T1 - Bovine tuberculosis in cattle
T2 - Vaccines, DIVA tests, and host biomarker discovery
AU - Vordermeier, H. Martin
AU - Jones, Gareth J.
AU - Buddle, Bryce M.
AU - Hewinson, R. Glyn
AU - Villarreal-Ramos, Bernardo
PY - 2016/2/15
Y1 - 2016/2/15
N2 - Bovine tuberculosis remains a major economic and animal welfare concern worldwide. Cattle vaccination is being considered as part of control strategies. This approach, used alongside conventional control policies, also requires the development of vaccine-compatible diagnostic assays to distinguish vaccinated from infected animals (DIVA). We discuss progress made on optimizing the only potentially available vaccine, bacille Calmette Gueacuterin (BCG), and on strategies to improve BCG efficacy. We also describe recent advances in DIVA development based on the detection of host cellular immune responses by blood-testing or skin-testing approaches. Finally, to accelerate vaccine development, definition of host biomarkers that provide meaningful stage-gating criteria to select vaccine candidates for further testing is highly desirable. Some progress has also been made in this area of research, and we summarize studies that defined either markers predicting vaccine success or markers that correlate with disease stage or severity.
AB - Bovine tuberculosis remains a major economic and animal welfare concern worldwide. Cattle vaccination is being considered as part of control strategies. This approach, used alongside conventional control policies, also requires the development of vaccine-compatible diagnostic assays to distinguish vaccinated from infected animals (DIVA). We discuss progress made on optimizing the only potentially available vaccine, bacille Calmette Gueacuterin (BCG), and on strategies to improve BCG efficacy. We also describe recent advances in DIVA development based on the detection of host cellular immune responses by blood-testing or skin-testing approaches. Finally, to accelerate vaccine development, definition of host biomarkers that provide meaningful stage-gating criteria to select vaccine candidates for further testing is highly desirable. Some progress has also been made in this area of research, and we summarize studies that defined either markers predicting vaccine success or markers that correlate with disease stage or severity.
KW - Cattle
KW - Correlates of protection
KW - Differential diagnosis
KW - Tuberculosis
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=84959058798&partnerID=8YFLogxK
U2 - 10.1146/annurev-animal-021815-111311
DO - 10.1146/annurev-animal-021815-111311
M3 - Article
C2 - 26884103
AN - SCOPUS:84959058798
SN - 2165-8102
VL - 4
SP - 87
EP - 109
JO - Annual Review of Animal Biosciences
JF - Annual Review of Animal Biosciences
IS - 1
ER -