This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic discovery and design of intervention strategies. Structured arguments over a model's development, underpinning biological knowledge, and analyses of model behaviors are constructed to determine the confidence that a model is fit for the purpose for which it will be applied.
- Antiprotozoal Agents/immunology
- Biomedical Engineering/methods
- Immunity, Cellular/drug effects
- Leishmaniasis, Visceral/immunology
- Models, Biological
- Systems Biology/methods