TY - JOUR
T1 - Characterization of age-related changes in bovine CD8 + T-cells
AU - Hogg, Alison E.
AU - Parsons, Keith
AU - Taylor, Geraldine
AU - Worth, Andrew
AU - Beverley, Peter
AU - Howard, Christopher J.
AU - Villarreal-Ramos, Bernardo
PY - 2011/3/15
Y1 - 2011/3/15
N2 - Evaluation of the changes induced by immunological interventions requires a baseline against which to compare those changes. The age-related changes in the CD8 + T-cell population of cattle were studied. The results indicate that CD8 + T-cells could be divided into γ/δ TCR1 + and γ/δ TCR1 - according to their expression of the γ/δ T-cell receptor. As a proportion, the CD8 + γ/δ TCR1 + population appears to increase with age. Within the CD8 +γ/δ TCR1 - a population of cells expressing a profile of surface molecules previously associated with effector memory T cells (CD45RO +, CD62L -, CD27 -, CD45RA - and CD28 -) increases with age. Furthermore, a parallel increase with age in the proportion of CD8 +CD45RO + T cells that express the cytotoxic granule protein perforin was observed. In peripheral tissues, namely lungs, it was found that the majority of CD8 + T cells present expressed a phenotype indicative of previously primed T cells (high expression of CD45RO and perforin). In contrast, only a small population of memory CD8 + T cells was present in lymphoid tissue where most of the CD8 + T cells expressed a naïve phenotype. In conclusion, in cattle, like in human, CD8 + T cells that express a phenotype associated with antigen experience accumulate with age that may play a role in immunocompetence as the individual ages.
AB - Evaluation of the changes induced by immunological interventions requires a baseline against which to compare those changes. The age-related changes in the CD8 + T-cell population of cattle were studied. The results indicate that CD8 + T-cells could be divided into γ/δ TCR1 + and γ/δ TCR1 - according to their expression of the γ/δ T-cell receptor. As a proportion, the CD8 + γ/δ TCR1 + population appears to increase with age. Within the CD8 +γ/δ TCR1 - a population of cells expressing a profile of surface molecules previously associated with effector memory T cells (CD45RO +, CD62L -, CD27 -, CD45RA - and CD28 -) increases with age. Furthermore, a parallel increase with age in the proportion of CD8 +CD45RO + T cells that express the cytotoxic granule protein perforin was observed. In peripheral tissues, namely lungs, it was found that the majority of CD8 + T cells present expressed a phenotype indicative of previously primed T cells (high expression of CD45RO and perforin). In contrast, only a small population of memory CD8 + T cells was present in lymphoid tissue where most of the CD8 + T cells expressed a naïve phenotype. In conclusion, in cattle, like in human, CD8 + T cells that express a phenotype associated with antigen experience accumulate with age that may play a role in immunocompetence as the individual ages.
KW - Age
KW - Cattle
KW - CD8 T cells
KW - Memory
UR - http://www.scopus.com/inward/record.url?scp=79960976041&partnerID=8YFLogxK
U2 - 10.1016/j.vetimm.2010.11.012
DO - 10.1016/j.vetimm.2010.11.012
M3 - Article
C2 - 21159386
AN - SCOPUS:79960976041
SN - 0165-2427
VL - 140
SP - 47
EP - 54
JO - Veterinary Immunology and Immunopathology
JF - Veterinary Immunology and Immunopathology
IS - 1-2
ER -