Characterization of age-related changes in bovine CD8 + T-cells

Alison E. Hogg, Keith Parsons, Geraldine Taylor, Andrew Worth, Peter Beverley, Christopher J. Howard, Bernardo Villarreal-Ramos*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Evaluation of the changes induced by immunological interventions requires a baseline against which to compare those changes. The age-related changes in the CD8 + T-cell population of cattle were studied. The results indicate that CD8 + T-cells could be divided into γ/δ TCR1 + and γ/δ TCR1 - according to their expression of the γ/δ T-cell receptor. As a proportion, the CD8 + γ/δ TCR1 + population appears to increase with age. Within the CD8 +γ/δ TCR1 - a population of cells expressing a profile of surface molecules previously associated with effector memory T cells (CD45RO +, CD62L -, CD27 -, CD45RA - and CD28 -) increases with age. Furthermore, a parallel increase with age in the proportion of CD8 +CD45RO + T cells that express the cytotoxic granule protein perforin was observed. In peripheral tissues, namely lungs, it was found that the majority of CD8 + T cells present expressed a phenotype indicative of previously primed T cells (high expression of CD45RO and perforin). In contrast, only a small population of memory CD8 + T cells was present in lymphoid tissue where most of the CD8 + T cells expressed a naïve phenotype. In conclusion, in cattle, like in human, CD8 + T cells that express a phenotype associated with antigen experience accumulate with age that may play a role in immunocompetence as the individual ages.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalVeterinary Immunology and Immunopathology
Issue number1-2
Early online date19 Nov 2010
Publication statusPublished - 15 Mar 2011


  • Age
  • Cattle
  • CD8 T cells
  • Memory


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