Classification of Microcalcification Clusters Based on Morphological Topology Analysis

Zhili Chen, Erika R. E. Denton, Reyer Zwiggelaar

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)

6 Citations (Scopus)

Abstract

The presence of microcalcification clusters is a primary sign of breast cancer. It is difficult and time consuming for radiologists to diagnose microcalcifications. In this paper, we present a novel method for classification of malignant and benign microcalcification clusters in mammograms. We analyse the connectivity/topology between individual microcalcifications within a cluster using multiscale morphology. A microcalcification graph is constructed to represent the topological structure of clusters. A multiscale topological feature vector is generated by extracting two microcalcification graph properties. The validity of the proposed method is evaluated using a dataset taken from the MIAS database. The performance of including SFS feature selection is investigated. Using a k-nearest neighbour classifier, a classification accuracy of 95% and an area under the ROC curve of 0.93 are achieved. A comparison with existing approaches is presented.
Original languageEnglish
Title of host publicationBreast Imaging - 11th International Workshop, IWDM 2012, Proceedings
Subtitle of host publication11th International Workshop, IWDM 2012, Philadelphia, PA, USA, July 8-11, 2012, Proceedings
EditorsAndrew D. A. Maidment, Predrag R. Bakic, Sara Gavenonis
PublisherSpringer Nature
Pages521-528
Number of pages8
ISBN (Electronic)978-3-642-31271-7
ISBN (Print)978-3-642-31270-0
DOIs
Publication statusPublished - 22 Jun 2012
Event11th International Workshop on Breast Imaging: IWDM 2012 - Philadelphia, United States of America
Duration: 08 Jul 201211 Jul 2012

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7361 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference11th International Workshop on Breast Imaging
Country/TerritoryUnited States of America
CityPhiladelphia
Period08 Jul 201211 Jul 2012

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