TY - JOUR
T1 - Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking
AU - Sikdar, Sinjini
AU - Joehanes, Roby
AU - Joubert, Bonnie R
AU - Xu, Cheng-Jian
AU - Vives-Usano, Marta
AU - Rezwan, Faisal I
AU - Felix, Janine F
AU - Ward, James M
AU - Guan, Weihua
AU - Richmond, Rebecca C
AU - Brody, Jennifer A
AU - Küpers, Leanne K
AU - Baïz, Nour
AU - Håberg, Siri E
AU - Smith, Jennifer A
AU - Reese, Sarah E
AU - Aslibekyan, Stella
AU - Hoyo, Cathrine
AU - Dhingra, Radhika
AU - Markunas, Christina A
AU - Xu, Tao
AU - Reynolds, Lindsay M
AU - Just, Allan C
AU - Mandaviya, Pooja R
AU - Ghantous, Akram
AU - Bennett, Brian D
AU - Wang, Tianyuan
AU - Consortium, The Bios
AU - Bakulski, Kelly M
AU - Melen, Erik
AU - Zhao, Shanshan
AU - Jin, Jianping
AU - Herceg, Zdenko
AU - Meurs, Joyce van
AU - Taylor, Jack A
AU - Baccarelli, Andrea A
AU - Murphy, Susan K
AU - Liu, Yongmei
AU - Munthe-Kaas, Monica Cheng
AU - Deary, Ian J
AU - Nystad, Wenche
AU - Waldenberger, Melanie
AU - Annesi-Maesano, Isabella
AU - Conneely, Karen
AU - Jaddoe, Vincent Wv
AU - Arnett, Donna
AU - Snieder, Harold
AU - Kardia, Sharon Lr
AU - Relton, Caroline L
AU - Ong, Ken K
AU - Ewart, Susan
AU - Moreno-Macias, Hortensia
AU - Romieu, Isabelle
AU - Sotoodehnia, Nona
AU - Fornage, Myriam
AU - Motsinger-Reif, Alison
AU - Koppelman, Gerard H
AU - Bustamante, Mariona
AU - Levy, Daniel
AU - London, Stephanie J
N1 - Funding Information:
29Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA 30Department of Environmental Medicine & Public Health, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA 31Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands 32Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands 33Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France 34Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 35Westat, Durham, NC 27703, USA 36Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York City, NY 10032, USA 37Departments of Obstetrics & Gynecology & Pathology, Duke University School of Medicine, Durham, NC 27708, USA 38Department of Pediatrics, Oslo University Hospital, Oslo, Norway 39National Institute of Public Health, Oslo, Norway 40Centre for Cognitive Ageing & Cognitive Epidemiology, Edinburgh, UK 41Department of Psychology, University of Edinburgh, Edinburgh, UK 42Division of Mental & Physical Health, Norwegian Institute of Public Health, Oslo, Norway 43Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany 44Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA 45MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK 46Department of Paediatrics, University of Cambridge, Cambridge, UK 47Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA 48Autonomous Metropolitan University Iztapalapa, Mexico City, Mexico 49Nutrition & Metabolism Section, International Agency for Research on Cancer, Lyon, France 50Center for Research on Population Health, National Institute of Public Health, Mexico 51Hubert Department of Global Health, Emory University, Atlanta, GA 30329, USA 52Institute of Molecular Medicine & Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225, USA 53Population Sciences Branch, National Heart, Lung, & Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA *Author for correspondence: [email protected]
Funding Information:
Funded by the Intramural Research Program of National Institutes of Health (National Institute of Environmental Health Sciences ZO1 ES49019) in addition to funding for individual authors and cohorts listed in the Supplementary Acknowledgements and Funding document. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
Publisher Copyright:
© 2019 Sinjini Sikdar.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.
AB - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.
KW - Adult
KW - Cohort Studies
KW - CpG Islands
KW - DNA Methylation
KW - Epigenesis, Genetic
KW - Epigenomics/methods
KW - Female
KW - Humans
KW - Infant, Newborn
KW - Maternal Exposure/adverse effects
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects/epidemiology
KW - Tobacco Smoking/epidemiology
KW - maternal exposure
KW - infant
KW - epigenetics
KW - cigarette smoking
KW - methylation
UR - http://www.scopus.com/inward/record.url?scp=85074118095&partnerID=8YFLogxK
U2 - 10.2217/epi-2019-0066
DO - 10.2217/epi-2019-0066
M3 - Article
C2 - 31536415
SN - 1750-192X
VL - 11
SP - 1487
EP - 1500
JO - Epigenomics
JF - Epigenomics
IS - 13
ER -
