Complete genome sequence of the myxobacterium Sorangium cellulosum

Susanne Schneiker; Olena Perlova; Olaf Kaiser; Klaus Gerth; Aysel Alici; Matthias O Altmeyer; Daniela Bartels; Thomas Bekel; Stefan Beyer; Edna Bode; Helge B Bode; Christoph J Bolten; Jomuna V Choudhuri; Sabrina Doss; Yasser A Elnakady; Bettina Frank; Lars Gaigalat; Alexander Goesmann; Carolin Groeger; Frank Gross; Lars Jelsbak; Lotte Jelsbak; Jörn Kalinowski; Carsten Kegler; Tina Knauber; Sebastian Konietzny; Maren Kopp; Lutz Krause; Daniel Krug; Bukhard Linke; Taifo Mahmud; Rosa Martinez-Arias; Alice C McHardy; Michelle Merai; Folker Meyer; Sascha Mormann; Jose Muñoz-Dorado; Juana Perez; Silke Pradella; Shwan Rachid; Günter Raddatz; Frank Rosenau; Christian Rückert; Florenz Sasse; Maren Scharfe; Stephan C Schuster; Garret Suen; Anke Treuner-Lange; Gregory J Velicer; Frank-Jörg Vorhölter; Kira J Weissman; Roy D Welch; Silke C Wenzel; David E Whitworth; Susanne Wilhelm; Christoph Wittmann; Helmut Blöcker; Alfred Pühler; Rolf Müller

doi:10.1038/nbt1354

Complete genome sequence of the myxobacterium Sorangium cellulosum

Susanne Schneiker, Olena Perlova, Olaf Kaiser, Klaus Gerth, Aysel Alici, Matthias O Altmeyer, Daniela Bartels, Thomas Bekel, Stefan Beyer, Edna Bode, Helge B Bode, Christoph J Bolten, Jomuna V Choudhuri, Sabrina Doss, Yasser A Elnakady, Bettina Frank, Lars Gaigalat, Alexander Goesmann, Carolin Groeger, Frank GrossLars Jelsbak, Lotte Jelsbak, Jörn Kalinowski, Carsten Kegler, Tina Knauber, Sebastian Konietzny, Maren Kopp, Lutz Krause, Daniel Krug, Bukhard Linke, Taifo Mahmud, Rosa Martinez-Arias, Alice C McHardy, Michelle Merai, Folker Meyer, Sascha Mormann, Jose Muñoz-Dorado, Juana Perez, Silke Pradella, Shwan Rachid, Günter Raddatz, Frank Rosenau, Christian Rückert, Florenz Sasse, Maren Scharfe, Stephan C Schuster, Garret Suen, Anke Treuner-Lange, Gregory J Velicer, Frank-Jörg Vorhölter, Kira J Weissman, Roy D Welch, Silke C Wenzel, David E Whitworth, Susanne Wilhelm, Christoph Wittmann, Helmut Blöcker, Alfred Pühler, Rolf Müller

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

312 Citations (Scopus)

Abstract

The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.

Original language	English
Pages (from-to)	1281-1289
Number of pages	9
Journal	Nature Biotechnology
Volume	25
Issue number	11
Early online date	28 Oct 2007
DOIs	https://doi.org/10.1038/nbt1354
Publication status	Published - 2007

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Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H. B., Bolten, C. J., Choudhuri, J. V., Doss, S., Elnakady, Y. A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., ... Müller, R. (2007). Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology, 25(11), 1281-1289. https://doi.org/10.1038/nbt1354

@article{df13315151984f9e83b85e043e8bdff3,

title = "Complete genome sequence of the myxobacterium Sorangium cellulosum",

abstract = "The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.",

author = "Susanne Schneiker and Olena Perlova and Olaf Kaiser and Klaus Gerth and Aysel Alici and Altmeyer, {Matthias O} and Daniela Bartels and Thomas Bekel and Stefan Beyer and Edna Bode and Bode, {Helge B} and Bolten, {Christoph J} and Choudhuri, {Jomuna V} and Sabrina Doss and Elnakady, {Yasser A} and Bettina Frank and Lars Gaigalat and Alexander Goesmann and Carolin Groeger and Frank Gross and Lars Jelsbak and Lotte Jelsbak and J{\"o}rn Kalinowski and Carsten Kegler and Tina Knauber and Sebastian Konietzny and Maren Kopp and Lutz Krause and Daniel Krug and Bukhard Linke and Taifo Mahmud and Rosa Martinez-Arias and McHardy, {Alice C} and Michelle Merai and Folker Meyer and Sascha Mormann and Jose Mu{\~n}oz-Dorado and Juana Perez and Silke Pradella and Shwan Rachid and G{\"u}nter Raddatz and Frank Rosenau and Christian R{\"u}ckert and Florenz Sasse and Maren Scharfe and Schuster, {Stephan C} and Garret Suen and Anke Treuner-Lange and Velicer, {Gregory J} and Frank-J{\"o}rg Vorh{\"o}lter and Weissman, {Kira J} and Welch, {Roy D} and Wenzel, {Silke C} and Whitworth, {David E} and Susanne Wilhelm and Christoph Wittmann and Helmut Bl{\"o}cker and Alfred P{\"u}hler and Rolf M{\"u}ller",

note = "Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H. B., Bolten, C. J., Choudhuri, J. V., Doss, S., Elnakady, Y. A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A. C., Merai, M., Meyer, F., Mormann, S., Mu{\~n}oz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., R{\"u}ckert, C., Sasse, F., Scharfe, M., Schuster, S. C., Suen, G., Treuner-Lange, A., Velicer, G. J., Vorh{\"o}lter, F-J., Weissman, K. J., Welch, R. D., Wenzel, S. C., Whitworth, D. E., Wilhelm, S., Wittmann, C., Bl{\"o}cker, H., P{\"u}hler, A., M{\"u}ller, R. (2007). Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology, 25 (11), 1281-1289.",

year = "2007",

doi = "10.1038/nbt1354",

language = "English",

volume = "25",

pages = "1281--1289",

journal = "Nature Biotechnology",

issn = "1087-0156",

publisher = "Springer Nature",

number = "11",

}

Schneiker, S, Perlova, O, Kaiser, O, Gerth, K, Alici, A, Altmeyer, MO, Bartels, D, Bekel, T, Beyer, S, Bode, E, Bode, HB, Bolten, CJ, Choudhuri, JV, Doss, S, Elnakady, YA, Frank, B, Gaigalat, L, Goesmann, A, Groeger, C, Gross, F, Jelsbak, L, Jelsbak, L, Kalinowski, J, Kegler, C, Knauber, T, Konietzny, S, Kopp, M, Krause, L, Krug, D, Linke, B, Mahmud, T, Martinez-Arias, R, McHardy, AC, Merai, M, Meyer, F, Mormann, S, Muñoz-Dorado, J, Perez, J, Pradella, S, Rachid, S, Raddatz, G, Rosenau, F, Rückert, C, Sasse, F, Scharfe, M, Schuster, SC, Suen, G, Treuner-Lange, A, Velicer, GJ, Vorhölter, F-J, Weissman, KJ, Welch, RD, Wenzel, SC, Whitworth, DE, Wilhelm, S, Wittmann, C, Blöcker, H, Pühler, A & Müller, R 2007, 'Complete genome sequence of the myxobacterium Sorangium cellulosum', Nature Biotechnology, vol. 25, no. 11, pp. 1281-1289. https://doi.org/10.1038/nbt1354

TY - JOUR

T1 - Complete genome sequence of the myxobacterium Sorangium cellulosum

AU - Schneiker, Susanne

AU - Perlova, Olena

AU - Kaiser, Olaf

AU - Gerth, Klaus

AU - Alici, Aysel

AU - Altmeyer, Matthias O

AU - Bartels, Daniela

AU - Bekel, Thomas

AU - Beyer, Stefan

AU - Bode, Edna

AU - Bode, Helge B

AU - Bolten, Christoph J

AU - Choudhuri, Jomuna V

AU - Doss, Sabrina

AU - Elnakady, Yasser A

AU - Frank, Bettina

AU - Gaigalat, Lars

AU - Goesmann, Alexander

AU - Groeger, Carolin

AU - Gross, Frank

AU - Jelsbak, Lars

AU - Jelsbak, Lotte

AU - Kalinowski, Jörn

AU - Kegler, Carsten

AU - Knauber, Tina

AU - Konietzny, Sebastian

AU - Kopp, Maren

AU - Krause, Lutz

AU - Krug, Daniel

AU - Linke, Bukhard

AU - Mahmud, Taifo

AU - Martinez-Arias, Rosa

AU - McHardy, Alice C

AU - Merai, Michelle

AU - Meyer, Folker

AU - Mormann, Sascha

AU - Muñoz-Dorado, Jose

AU - Perez, Juana

AU - Pradella, Silke

AU - Rachid, Shwan

AU - Raddatz, Günter

AU - Rosenau, Frank

AU - Rückert, Christian

AU - Sasse, Florenz

AU - Scharfe, Maren

AU - Schuster, Stephan C

AU - Suen, Garret

AU - Treuner-Lange, Anke

AU - Velicer, Gregory J

AU - Vorhölter, Frank-Jörg

AU - Weissman, Kira J

AU - Welch, Roy D

AU - Wenzel, Silke C

AU - Whitworth, David E

AU - Wilhelm, Susanne

AU - Wittmann, Christoph

AU - Blöcker, Helmut

AU - Pühler, Alfred

AU - Müller, Rolf

N1 - Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H. B., Bolten, C. J., Choudhuri, J. V., Doss, S., Elnakady, Y. A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A. C., Merai, M., Meyer, F., Mormann, S., Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S. C., Suen, G., Treuner-Lange, A., Velicer, G. J., Vorhölter, F-J., Weissman, K. J., Welch, R. D., Wenzel, S. C., Whitworth, D. E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A., Müller, R. (2007). Complete genome sequence of the myxobacterium Sorangium cellulosum. Nature Biotechnology, 25 (11), 1281-1289.

PY - 2007

Y1 - 2007

N2 - The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.

AB - The genus Sorangium synthesizes approximately half of the secondary metabolites isolated from myxobacteria, including the anti-cancer metabolite epothilone. We report the complete genome sequence of the model Sorangium strain S. cellulosum So ce56, which produces several natural products and has morphological and physiological properties typical of the genus. The circular genome, comprising 13,033,779 base pairs, is the largest bacterial genome sequenced to date. No global synteny with the genome of Myxococcus xanthus is apparent, revealing an unanticipated level of divergence between these myxobacteria. A large percentage of the genome is devoted to regulation, particularly post-translational phosphorylation, which probably supports the strain's complex, social lifestyle. This regulatory network includes the highest number of eukaryotic protein kinase-like kinases discovered in any organism. Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry.

UR - http://hdl.handle.net/2160/12864

U2 - 10.1038/nbt1354

DO - 10.1038/nbt1354

M3 - Article

C2 - 17965706

SN - 1087-0156

VL - 25

SP - 1281

EP - 1289

JO - Nature Biotechnology

JF - Nature Biotechnology

IS - 11

ER -

Complete genome sequence of the myxobacterium Sorangium cellulosum

Abstract

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