Computational models of the NF-κB signalling pathway

Richard A. Williams*, Jon Timmis, Eva E. Qwarnstrom

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

48 Citations (SciVal)


In this review article, we discuss the current state of computational modelling ofthe nuclear factor-kappa B (NF-κB) signalling pathway. NF-κB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-κB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-κB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-κB control.

Original languageEnglish
Pages (from-to)131-158
Number of pages28
Issue number4
Publication statusPublished - 2014
Externally publishedYes


  • Agent-based modelling
  • Computational biology
  • Mathematical modelling
  • NF-κB
  • Signal transduction
  • Systems biology


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