TY - JOUR
T1 - Computational models of the NF-κB signalling pathway
AU - Williams, Richard A.
AU - Timmis, Jon
AU - Qwarnstrom, Eva E.
N1 - Funding Information:
Richard A. Williams would like to acknowledge the White Rose Universities Consortium for an Immune Modelling Network Doctoral Studentship. Jon Timmis is part-funded by The Royal Society, The Royal Academy of Engineering and the Engineering and Physical Sciences Research Council (EPSRC) Grant No. EP/E053505/1. The York Computational Immunology Laboratory is part-funded by the Wellcome Trust (Ref: 097829) through the Centre for Chronic Diseases and Disorders (C2D2) at the University of York. The Cell Biology Laboratory in Cardiovascular Sciences at the University of Sheffield, is in part funded by the Biotechnology and Biological Sciences Research Council (BBSRC) Grant No. BB/J009687/1 awarded to Eva E. Qwarnstrom.
Publisher Copyright:
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2014
Y1 - 2014
N2 - In this review article, we discuss the current state of computational modelling ofthe nuclear factor-kappa B (NF-κB) signalling pathway. NF-κB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-κB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-κB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-κB control.
AB - In this review article, we discuss the current state of computational modelling ofthe nuclear factor-kappa B (NF-κB) signalling pathway. NF-κB is a transcription factor, which is ubiquitous within cells and controls a number of immune responses, including inflammation and apoptosis. The NF-κB signalling pathway is tightly regulated, commencing with activation at the cell membrane, signal transduction through various components within the cytoplasm, translocation of NF-κB into the nucleus and, finally, the transcription of various genes relating to the innate and adaptive immune responses. There have been a number of computational (mathematical) models developed of the signalling pathway over the past decade. This review describes how these approaches have helped advance our understanding of NF-κB control.
KW - Agent-based modelling
KW - Computational biology
KW - Mathematical modelling
KW - NF-κB
KW - Signal transduction
KW - Systems biology
UR - https://www.scopus.com/pages/publications/84937566091
U2 - 10.3390/computation2040131
DO - 10.3390/computation2040131
M3 - Review Article
AN - SCOPUS:84937566091
SN - 2079-3197
VL - 2
SP - 131
EP - 158
JO - Computation
JF - Computation
IS - 4
ER -