Cortical and trabecular bone at the radius and tibia in male and female adolescents with Down syndrome: a peripheral quantitative computed tomography (pQCT) study

Alejandro Gonzalez de Aguero, G Vicente-Rodríguez, A Gómez-Cabello, J A Casajús

    Research output: Contribution to journalArticlepeer-review

    30 Citations (SciVal)
    237 Downloads (Pure)

    Abstract

    We aimed to describe the structure and strength of the tibia and radius of adolescents with Down syndrome. We observed that despite higher levels of volumetric bone mineral density in determined skeletal sites, they are at higher risk of developing osteoporotic fractures in the future due to their lower bone strength indexes. INTRODUCTION: The aims of the study were to describe the cortical and trabecular volumetric bone mineral density (vBMD), bone mineral content (BMC), area, and bone strength in adolescents with Down syndrome (DS) and to compare them with adolescents without disabilities. METHODS: Thirty adolescents (11 girls) with DS and 28 without disabilities (10 girls) participated in the study. Peripheral quantitative computed tomography measurements were taken at proximal and distal sites of the tibia and radius. Values of total, trabecular, and cortical BMC; vBMD; and area were obtained of each scan. Cortical thickness and endosteal and periosteal circumferences were also measured, and different bone strength indexes were calculated. Student's t tests were applied between groups. RESULTS: The DS group showed greater vBMD at distal radius, BMC at proximal radius, and total and cortical vBMD at proximal tibia. The non-DS group showed higher total and trabecular area at the distal radius and total, cortical, and trabecular BMC and area at distal tibia. Higher values of periosteal and endosteal circumference and bone strength were also found in non-DS group. CONCLUSIONS: From these results, it can be believed that even with higher vBMD in determined skeletal sites, adolescents with DS are at higher risk of suffering bone fractures due to an increased fragility by lower resistance to load bending or torsion.
    Original languageEnglish
    Pages (from-to)1035-1044
    Number of pages10
    JournalOsteoporosis International
    Volume24
    Issue number3
    DOIs
    Publication statusPublished - Mar 2013

    Keywords

    • Body composition
    • Bone geometry
    • Bone strength
    • Osteoporosis
    • vBMD

    Fingerprint

    Dive into the research topics of 'Cortical and trabecular bone at the radius and tibia in male and female adolescents with Down syndrome: a peripheral quantitative computed tomography (pQCT) study'. Together they form a unique fingerprint.

    Cite this