Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

I. Skujina, C. L. Winton, M. J. Hegarty, R. McMahon, D. M. Nash, M. C. G. Davies-Morel, N. R. McEwan

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Abstract

Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in four pony breeds native to the British Isles, including two different sections within Welsh Cobs. In this study, a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤ 10 -5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8, and ECA16.

Original languageEnglish
Pages (from-to)767-770
Number of pages4
JournalGenome
Volume61
Issue number10
Early online date05 Sept 2018
DOIs
Publication statusPublished - Oct 2018

Keywords

  • Genome-wide association
  • Height
  • High density genotyping
  • Horse
  • Quantitative trait loci
  • Single nucleotide polymorphisms
  • Breeding
  • Chromosome Mapping
  • Biometry
  • Horses/anatomy & histology
  • Animals
  • High-Throughput Nucleotide Sequencing
  • Polymorphism, Single Nucleotide
  • Whole Genome Sequencing/methods
  • Genotyping Techniques/methods
  • Chromosomes, Mammalian/genetics
  • Quantitative Trait Loci

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