Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

I. Skujina; C. L. Winton; M. J. Hegarty; R. McMahon; D. M. Nash; M. C. G. Davies-Morel; N. R. McEwan

doi:10.1139/gen-2018-0006

Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

I. Skujina, C. L. Winton, M. J. Hegarty, R. McMahon, D. M. Nash, M. C. G. Davies-Morel, N. R. McEwan

Department of Life Sciences

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Abstract

Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in 4 pony breeds native to the British Isles, including 2 different sections within Welsh Cobs. In this study,
a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤10-5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8 and ECA16

Original language	English
Pages (from-to)	767-770
Number of pages	4
Journal	Genome
Volume	61
Issue number	10
Early online date	05 Sept 2018
DOIs	https://doi.org/10.1139/gen-2018-0006
Publication status	E-pub ahead of print - 05 Sept 2018

Keywords

height
horse
single nucleotide polymorphisms
genome wide association
high density genotyping
quantitative trait loci

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10.1139/gen-2018-0006Licence: CC BY-NC

Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotypingAccepted author manuscript, 462 KBLicence: CC BY-NC

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title = "Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping",

abstract = "Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in 4 pony breeds native to the British Isles, including 2 different sections within Welsh Cobs. In this study,a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤10-5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8 and ECA16",

keywords = "height, horse, single nucleotide polymorphisms, genome wide association, high density genotyping, quantitative trait loci",

author = "I. Skujina and Winton, {C. L.} and Hegarty, {M. J.} and R. McMahon and Nash, {D. M.} and Davies-Morel, {M. C. G.} and McEwan, {N. R.}",

year = "2018",

month = sep,

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doi = "10.1139/gen-2018-0006",

language = "English",

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journal = "Genome",

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T1 - Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

AU - Skujina, I.

AU - Winton, C. L.

AU - Hegarty, M. J.

AU - McMahon, R.

AU - Nash, D. M.

AU - Davies-Morel, M. C. G.

AU - McEwan, N. R.

PY - 2018/9/5

Y1 - 2018/9/5

N2 - Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in 4 pony breeds native to the British Isles, including 2 different sections within Welsh Cobs. In this study,a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤10-5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8 and ECA16

AB - Height is an important characteristic in the equine industry although little is known about its genetic control in native British breeds of ponies. This study aimed to map QTL data with the withers height in 4 pony breeds native to the British Isles, including 2 different sections within Welsh Cobs. In this study,a genome-wide analysis approach using the Illumina EquineSNP50 Infinium BeadChip was applied to 105 ponies and cobs. Analysis identified 222 highly significant height-associated SNPs (P ≤10-5), among which three SNPs on ECA9 have also been previously reported elsewhere. The highest number of significant SNPs associated to height in the native British horses were located on ECA1, ECA8 and ECA16

KW - height

KW - horse

KW - single nucleotide polymorphisms

KW - genome wide association

KW - high density genotyping

KW - quantitative trait loci

U2 - 10.1139/gen-2018-0006

DO - 10.1139/gen-2018-0006

M3 - Article

C2 - 30184439

SN - 0831-2796

VL - 61

SP - 767

EP - 770

JO - Genome

JF - Genome

IS - 10

ER -

Detecting genetic regions associated with height in the native ponies of the British Isles by using high density SNP genotyping

Abstract

Keywords

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